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Radiotherapy-induced abscopal effects in immune checkpoint inhibitor-refractory metastatic disease: results from a large multicenter real-world cohort study.
Combining radiotherapy with immune checkpoint inhibitors (RT-ICI) triggers systemic antitumor responses, such as abscopal effects (AbE). Predictors of AbE and its impact on survival in real-world settings remain poorly defined. This multice…
FULLTEXT: Predictive Modelling -
Integrating tumor and immune cell transcriptomics to predict immune checkpoint inhibitor primary resistance in metastatic melanoma.
The emergence of immune checkpoint inhibitors (ICIs) has transformed the treatment landscape of metastatic melanoma. However, despite its success, reliable biomarkers for predicting primary resistance are not available in clinical practice.…
FULLTEXT: Predictive Modelling -
Gene-level gut microbiome signatures as predictive biomarkers for response to immune checkpoint inhibitors across multiple cancer types.
Targeting programmed cell death protein 1 (PD-1) and cytotoxic T-lymphocyte-associated protein 4 (CTLA-4) with immune checkpoint inhibitors (ICIs) has improved survival across multiple cancer types, but the variability in patient response h…
FULLTEXT: Predictive Modelling -
CAR T therapy in adult DLBCL patients in Slovenia: Evaluation of predictive scores for outcomes and adverse events.
CAR T cell therapy is a promising immunotherapy for hematologic malignancies, yet early prediction of outcomes and adverse events remains difficult, especially in small real-world cohorts. We retrospectively analyzed 14 adult patients with …
FULLTEXT: Predictive Modelling -
Development and validation of a nomogram for the overall survival of patients with locally advanced prostate cancer treated with radiotherapy and surgery.
[BACKGROUND] Prostate cancer (PC) is a common malignancy in older adults. We aimed to construct a nomogram for the overall survival (OS) of elderly patients with locally advanced PC who received radiotherapy and surgery. [METHODS] Clinical…
FULLTEXT: Predictive Modelling -
Clinical and nutritional-inflammatory biomarkers-based nomogram predicts survival in recurrent or metastatic cervical cancer treated with immune checkpoint inhibitors.
[BACKGROUND] Immunotherapy offers potential benefits for recurrent or metastatic cervical cancer (R/M CC), yet personalized predictive tools are essential for optimizing treatment. This study aims to develop a nomogram integrating nutrition…
FULLTEXT: Predictive Modelling -
Economic evaluation of perioperative pembrolizumab plus standard of care as treatment for resectable locally advanced head and neck squamous cell carcinoma in the United States.
[AIMS] In the phase 3 KEYNOTE-689 trial (NCT03765918) among patients with resectable locally advanced head and neck squamous cell carcinoma (LA HNSCC), perioperative pembrolizumab (pembrolizumab before surgery, then continued with standard-…
FULLTEXT: Predictive Modelling -
Real world incidence, predictors and outcomes of endocrine immune-related adverse events following immune checkpoint inhibitors.
Endocrine dysfunction is one of the most common immune-related adverse events (irAEs) reported in immune checkpoint inhibitors (ICIs) clinical trials. The aim of this research was to thoroughly assess the clinical features of endocrine irAE…
FULLTEXT: Predictive Modelling -
Pre-ablation stimulated thyroglobulin to TSH ratio as a strong predictor of non-generally satisfactory response to initial radioiodine therapy in papillary thyroid carcinoma patients undergoing lateral neck dissection.
[BACKGROUND] The initial response to radioiodine (³I) therapy is a critical determinant of prognosis in papillary thyroid carcinoma (PTC) patients undergoing therapeutic lateral neck dissection (LND). This study aimed to identify predictors…
FULLTEXT: Predictive Modelling -
Diagnostic performance and generalizability of a clinical-ultrasound radiomics model for predicting extrathyroidal extension in thyroid carcinoma: a retrospective study.
[BACKGROUND] Ultrasound plays a crucial role in the preoperative evaluation of thyroid carcinoma and its extrathyroidal extension (ETE). This study aims to develop and validate a model integrating ultrasound radiomics and clinical factors f…
FULLTEXT: Predictive Modelling -
Durable response of anaplastic thyroid cancer to pembrolizumab combined with chemotherapy: A case report.
Anaplastic thyroid cancer is a notoriously aggressive malignancy with a dismal prognosis, typically associated with a median overall survival of less than one year. Therapeutic alternatives are particularly limited for patients without acti…
FULLTEXT: Predictive Modelling -
Development and validation of a predictive model for high-risk immune-related adverse events in gastric cancer patients treated with ICIs.
Immune checkpoint inhibitors (ICIs) may cause immune-related adverse events (irAEs), ranging from mild to life-threatening. High-risk irAEs can lead to treatment discontinuation and higher mortality, though ICI-treated patients' death rate …
FULLTEXT: Predictive Modelling -
Risk factors and prediction model for early high-output stoma after colorectal cancer surgery: A retrospective study.
[OBJECTIVE] This retrospective cohort study aimed to identify independent risk factors for early high-output stoma (HOS) following colorectal cancer (CRC) surgery and to construct and validate a predictive nomogram. [METHODS] Consecutive p…
FULLTEXT: Predictive Modelling -
Neurotransmitter receptor-associated gene signature: prognostic and immunosuppressive microenvironment in NSCLC.
[OBJECTIVE] This study sought to identify neurotransmitter receptor-related genes (NR-RGs) that are critically involved in non-small cell lung cancer (NSCLC) through bioinformatics approaches. [METHODS] The TCGA-NSCLC dataset was utilized …
FULLTEXT: Predictive Modelling -
Development and Validation of Nomograms to Predict Overall Survival and Cancer-Specific Survival for Non-Small Cell Lung Cancer with Chest Wall Invasion: A Retrospective Study Based on SEER Database.
[BACKGROUND] Chest wall invasion is a relatively kind of infrequent direct tumor extension in non-small cell lung cancer (NSCLC) with a poor survival outcome. Risk factors that impact overall survival (OS) and cancer-specific survival (CSS)…
FULLTEXT: Predictive Modelling -
Advancing the understanding of the immune escape in lung cancer immunotherapy: Global trends, collaborations, and future directions.
Immune escape mechanisms critically restrict the efficacy of immunotherapy in lung cancer (LC), with only 20%-30% of patients responding to checkpoint inhibitors. To systematically map global trends and identify emerging hotspots, this stud…
FULLTEXT: Predictive Modelling -
Integrated machine learning risk model for predicting radiation pneumonitis in lung cancer patients with interstitial lung disease.
[BACKGROUND] Radiation pneumonitis (RP) is a serious complication in lung cancer patients with pre-existing interstitial lung disease (ILD) undergoing radiotherapy. Accurate risk stratification is crucial for individualized management. But …
FULLTEXT: Predictive Modelling -
Single-cell RNA sequencing analysis of bone cancer pain model induced by Lewis lung cancer cells in male mice.
[BACKGROUND] Bone cancer pain (BCP) is one of the most severe complications faced by cancer patients, with complex physiological and pathological mechanisms and unclear molecular characteristics. [METHODS] The BCP model was established by …
FULLTEXT: Predictive Modelling -
Prediction of high-risk factor in early-stage lung cancer: micropapillary adenocarcinoma.
[OBJECTIVE] To identify independent risk factors for micropapillary adenocarcinoma (MPA) in lung adenocarcinoma, a subtype often associated with poor prognosis, in order to support preoperative risk assessment and treatment planning. [METH…
FULLTEXT: Predictive Modelling -
Nomograms for the prognosis prediction model of early-stage triple-negative breast cancer - based on SEER database.
[AIMS] Triple-negative breast cancer (TNBC) is aggressive and unresponsive to hormone therapy, drawing widespread attention to its treatment and prognosis. This study aimed to summarize the prognosis of early-stage TNBC and construct nomogr…
FULLTEXT: Predictive Modelling