Yang L ⚠ 동명이인 가능성

[INTRODUCTION] Allergic airway inflammation (AAI), an asthma-like condition, is characterized by Th17/Treg imbalance and PD-1/PD-L1 pathway dysregulation. Yanghe Pingchuan Granules (YP) formulation is clinically used to treat asthma, but it…

[UNLABELLED] Objective. Myelofibrosis (MF) represents a hallmark of the advanced stage of myeloproliferative neoplasms (MPNs), and anemia serves as an independent factor for poor prognosis. Our study aimed to explore the gene and protein pr…

For sinonasal intestinal-type adenocarcinoma (ITAC), no standardized treatment exists, particularly for cases with advanced-stage disease with intracranial invasion or recurrence. The present study describes the case of a 60-year-old male p…

Ferroptosis, an iron-dependent, lipid peroxidation-driven programmed cell death, holds substantial promise for cancer therapy, yet its translational potential is hindered by widespread intrinsic resistance. While glutathione peroxidase 4 (G…

Cancer-related transcriptional dysregulation involves complex, incompletely understood epigenetic mechanisms. Chromatin states (CSs), defined by recurrent co-occurrence patterns of epigenetic marks, provide a comprehensive view for epigenom…

[BACKGROUND] Acute erythroleukemia (AEL) is a rare type of acute myeloid leukemia characterized by severe anemia. Roxadustat is a marketed first-generation hypoxia inducible factor-proline hydroxylase inhibitor (HIF-PHI), currently widely u…

Immunosuppressive therapy (IST) is the standard treatment for acquired pure red cell aplasia (aPRCA), but predictors of treatment response and long-term prognosis remain unclear. The clinical significance of somatic mutations in aPRCA is no…

[BACKGROUND] Infectious mononucleosis (IM), caused by Epstein-Barr virus (EBV) infection, is a prevalent disease among children and young adults and may lead to a range of severe complications. Proteomic analysis of extracellular vesicles (…

[PURPOSE] To develop and validate a scoring system that combines clinical and radiological variables to predict the likelihood of clinically significant prostate cancer (csPCa, which is defined as Gleason Grade group ≥ 2) before biopsy and …

[OBJECTIVE] To explore the stratification differences of MRI and prostate-specific antigen (PSA) density (PSAD) in the peripheral zone (PZ) and transition zone (TZ) lesions, in order to optimize the biopsy decision for patients with PSA 4-2…

[PURPOSE] This study evaluates the prognostic value of baseline F-PSMA-1007 PET/CT-derived volumetric metabolic parameters in metastatic castration-resistant prostate cancer (mCRPC) patients initiating first-line androgen receptor pathway i…

[BACKGROUND] Prostate cancer (PCa) remains a major clinical challenge, with postoperative recurrence risk varying substantially among patients. Emerging evidence suggests that serum biomarkers, including α-methylacyl-CoA racemase (AMACR) an…

[BACKGROUND] Radium-223 (Ra-223) received U.S. Food and Drug Administration (FDA) approval for treating castration-resistant prostate cancer with symptomatic bone metastases, excluding visceral metastases. Despite this, the safety profile o…

Epidemiological studies have suggested associations between dietary intake and gastric ulcer (GU) or gastric cancer (GC), but the causal relationships remain unclear. This study aimed to clarify these links using bidirectional and mediation…

Epstein-Barr virus (EBV) lytic replication is a key driver of viral dissemination and tumorigenicity in epithelial malignancies, such as nasopharyngeal carcinoma (NPC) and gastric cancer (GC). However, the underlying molecular mechanism and…

Hepatocellular carcinoma (HCC) is a highly prevalent and lethal malignancy with complex pathogenesis and limited treatment options. Exosomes play crucial roles in HCC development and progression. This study aimed to comprehensively investig…

[BACKGROUND] In recent years, immunotherapy has gained increasing prominence in the treatment of hepatocellular carcinoma (HCC). However, effective immune-related biomarkers for HCC remain limited. In this study, both transcriptomic data an…

[PURPOSE] To enhance the clinical management of hepatocellular carcinoma (HCC), we explored how conventional ultrasound and pathological features vary with microvascular invasion (MVI) status. We identified key risk factors for MVI and deve…

Timely identification of patients who meet clinical trial eligibility criteria is a persistent bottleneck in trial recruitment because the criteria are written in flexible natural language, while hospital EHRs are stored in structured schem…

[BACKGROUND] Tumors located at the Caudate lobe are challenging due to proximity to major vessels, increasing recurrence risk and surgical difficulty. Neoadjuvant therapy has been explored for hepatocellular carcinoma (HCC) patients with hi…

Hepatocellular carcinoma (HCC) is a metabolically active malignancy. Cuproptosis, a copper-dependent programmed cell death pathway, has been found to be closely associated with tumor progression. Cells with strong oxidative phosphorylation …

is recognized as a promising probiotic that improves the symptoms of a variety of diseases. However, the role and mechanism of in regulating intestinal homeostasis remain to be explored. Here, we discovered that was dramatically increased…

The management of lung adenocarcinoma with brain metastases (BMs) is particularly challenging when BRAF-V600E mutations emerge as a resistance mechanism to EGFR tyrosine kinase inhibitors. While the combination of BRAF/MEK inhibitors (e.g.,…

[ETHNOPHARMACOLOGICAL RELEVANCE] Lung cancer remains a leading cause of cancer-related mortality worldwide, and resistance to therapies such as gefitinib presents a significant challenge. Marsdenia tenacissima (Roxb.) Wight et Arn., a tradi…

[AIM] Diminished pulmonary function and psychological distress, which are common following lobectomy in lung cancer patients, represent a hindrance to the overall recovery. This study aimed to retrospectively explore the effects of preopera…

Bergapten, a furocoumarin, was assessed for its potential as a therapeutic agent targeting non-small cell lung cancer (NSCLC) using comprehensive computational approaches. Geometry optimization and electronic property calculations were perf…

To investigate the mechanisms of early brain metastasis in non-small cell lung cancer (NSCLC) using spatial multi-omics technology, develop predictive models, and identify potential therapeutic targets. A retrospective analysis was conducte…

[OBJECTIVE] To identify independent risk factors for micropapillary adenocarcinoma (MPA) in lung adenocarcinoma, a subtype often associated with poor prognosis, in order to support preoperative risk assessment and treatment planning. [METH…