논문 목록
121건-
Engineering Metal-Organic-Framework-Based STING Nanoagonists for PROTAC-Enhanced Cancer Chemo-Metalloimmunotherapy.
Chemo-metalloimmunotherapy is emerging as a promising strategy for cancer treatment by integrating chemotherapy-induced immunogenicity with metal ion-mediated immune activation. However, its efficacy is hampered by chemoresistance and immun…
-
Neoadjuvant camrelizumab combined with metronomic chemotherapy in patients with advanced esophageal squamous cell carcinoma: a pilot randomized phase 2 trial.
[BACKGROUND] Compared to conventional chemotherapy, metronomic chemotherapy (MCT), with lower drug dosage which may cause less damage to the immune system, has shown potential for synergy in combination with PD-1-based immunotherapy. Howeve…
-
Exploratory study of PD-1 inhibitors with or without ruxolitinib for the treatment of adult EBV-associated hemophagocytic lymphohistiocytosis: a real-world data-based preliminary investigation.
To preliminarily analyze the clinical efficacy and safety of PD-1 inhibitors as monotherapy or in combination with ruxolitinib (RUX) for adult Epstein-Barr virus-associated hemophagocytic lymphohistiocytosis (EBV-HLH) based on real-world re…
-
FAP fibroblasts promote C1QC macrophage infiltration via WNT2 signaling to exacerbate T cell exhaustion in oral squamous cell carcinoma.
The crosstalk between cancer-associated fibroblasts (CAFs) and immune cells drives immunosuppressive tumor microenvironment (TME) in oral squamous cell carcinoma (OSCC), but the underlying mechanisms remain poorly understood. Here, we ident…
-
[Malignant melanoma with anaplastic lymphoma kinase positivity: a clinicopathological analysis of three cases].
To investigate the expression of anaplastic lymphoma kinase (ALK) in malignant melanoma and analyze its clinicopathological and molecular features. Eighty-seven malignant melanomas that were surgically resected at the First Affiliated Hosp…
-
Dynamic monitoring of circulating cell-free EBV-DNA for risk assessment in early-stage natural killer/T-cell lymphoma.
While circulating tumor DNA (ctDNA) has shown promise in real-time monitoring of recurrence risk in various solid tumors, the clinical relevance of cell-free EBV-DNA (cfEBV-DNA) in natural killer/T-cell lymphoma (NKTCL) remains unclear. In …
- Validation of Prospective Cutaneous Lymphoma International Prognostic Index for advanced cutaneous lymphoma in a multicenter Chinese cohort.
-
The Pharmacokinetics and Relative Bioavailability of a Mini-Tablet of Mercaptopurine, a Novel Formulation for Use in Children with Acute Lymphoblastic Leukemia.
A novel 5 mg mini-tablet formulation of mercaptopurine (6-MP) was developed to provide flexible and accurate doses to treat children with acute lymphoblastic leukemia. We conducted two open-label, randomized, single-dose, four-period, two-s…
-
Erythrocyte membrane-liposome coating sustains circulation stability and targeted tumor therapy of CAR-T cells.
[BACKGROUND] CAR-T therapy is limited by off-target sequestration in liver, spleen, and lungs, which reduces tumor delivery and risks systemic toxicity. Genetic engineering approaches are complex and carry safety concerns, necessitating eff…
-
Successful treatment of hairy cell leukemia with TP53 abnormality using cladribine combined with low-dose rituximab: a case report and literature review.
Hairy cell leukemia (HCL) is a rare mature B-cell malignancy characterized by the BRAF V600E mutation. TP53 abnormalities in HCL are associated with poor response to standard therapies and a higher risk of relapse. We report an elderly male…
-
Design, synthesis and pharmacological evaluation of 3-spiro[benzofuran-2,4'-piperidine] IRAK4 inhibitors for the treatment of diffuse large B-cell lymphoma.
Interleukin-1 receptor-associated kinase 4 (IRAK4) has emerged as a promising target for the treatment of diffuse large B-cell lymphoma (DLBCL). Herein, we report the identification and structure-activity relationship studies of a new serie…
-
GFER Represents a Target for Dual Disruption of Redox Homeostasis and Reactivation of the Immune Response in Pancreatic Adenocarcinoma.
[UNLABELLED] Both metabolic dysregulation and the immunosuppressive tumor microenvironment of pancreatic ductal adenocarcinoma (PDAC) contribute to the recalcitrance of this lethal disease to treatment. Accordingly, we aimed to identify and…
-
Investigating the effects of air pollution on papillary thyroid cancer based on network toxicology and molecular docking.
[BACKGROUND] Recent studies have highlighted the association between various diseases and air pollution. This study aims to investigate the impact of air pollutants on the pathogenesis of papillary thyroid carcinoma (PTC) and the underlying…
-
Effect of thyrotropin suppression therapy on bone microarchitecture in postoperative patients with differentiated thyroid cancer.
[BACKGROUND] One of the main hazards of long-term subclinical hyperthyroidism is the induction and acceleration of osteoporosis. The aim of this study was to investigate the effect of postoperative thyrotropin (TSH) suppression therapy on b…
-
Durable response of anaplastic thyroid cancer to pembrolizumab combined with chemotherapy: A case report.
Anaplastic thyroid cancer is a notoriously aggressive malignancy with a dismal prognosis, typically associated with a median overall survival of less than one year. Therapeutic alternatives are particularly limited for patients without acti…
-
Relationship between infection or inflammation of prostate and risk of prostate cancer: a cross-sectional population-based study.
[BACKGROUND] The association between infection or inflammation of prostate and the risk of prostate cancer (PCa) remains a contentious issue. This article aims to assess the relationship between infection or inflammation of prostate and the…
- Autoimmunity and gastric cancer: pooled risks without pooled biology, methodological cautions before clinical translation - correspondence.
-
H3K27 acetylation activated-CYP1B1 promotes invasion, migration and radioresistance in gastric cancer via p38 MAPK-mediated fatty acid metabolism.
[INTRODUCTION] Gastric cancer (GC) is the fifth commonest malignant tumor in the world and ranks third in all cancer-related deaths. Patients suffering from advanced GC have poor prognosis due to metastasis and the resistance to radiotherap…
-
Zinc Finger Protein 706 Gene a Potential Diagnostic and Therapeutic Target in Hepatocellular Carcinoma: Implications for Cancer Biotechnology.
[BACKGROUND] Zinc finger proteins, particularly Zinc Finger Protein 706 (ZNF706), have been implicated in various cancers, yet their functional and clinical significance in hepatocellular carcinoma (HCC) remains unclear. Identifying novel b…
-
TGF-β1/SMAD signaling downregulates KLF4 expression via direct transcriptional suppression and FAT10-mediated proteasomal degradation in hepatocellular carcinoma.
[BACKGROUND] Loss of tumor suppressor Krüpple-like factor 4 (KLF4) expression in hepatocellular carcinoma (HCC) is crucial for aggressive tumor progression and poor patient prognosis. However, the mechanisms underlying KLF4 loss in human HC…
-
KLF1 Exerts Pro-Tumour Role in Liver Cancer via Inhibiting ACSL4/LPCAT3-Regulated Ferroptosis.
Kruppel-like factors (KLFs) constitute a crucial family of transcription factors that are engaged in a variety of biological processes, such as erythropoiesis as well as liver development. A growing body of research underscores the increasi…
-
Pathogenic Mechanisms and Therapeutic Approaches of Intestinal Flora in the Immune Microenvironment of Hepatocellular Carcinoma.
This paper initially presents an overview of the fundamental aspects of Hepatocellular carcinoma (HCC), intestinal microbiota, and the immune microenvironment. The paper discusses how metabolites from intestinal microbiota, such as lipopoly…
-
Mixed-model and transcriptome-wide association analyses identify transcription factors and genes associated with colorectal cancer susceptibility.
Susceptibility transcription factors (TF) whose DNA bindings are altered by genetic variants regulating colorectal cancer (CRC) risk genes remain poorly defined. Using generalized linear mixed models, we analyze 218 TF ChIP-Seq datasets alo…
-
USP1 promotes hepatocellular carcinoma progression by modulating mitophagy via stabilizing MCM3 to regulate the Keap1-Nrf2 axis.
Hepatocellular carcinoma (HCC) is a common malignant tumor with a high mortality rate. High mitophagy levels can promote hepatic tumor progression; therefore, inhibiting mitophagy may be a promising therapeutic strategy. This study shows th…
-
ANGPTL3 promotes colorectal carcinoma progression and metastasis through regulating COL1A2 transcription via interacting with integrin αVβ3.
Distant metastasis constitutes the predominant determinant of adverse prognosis and mortality in colorectal cancer (CRC), with hepatic dissemination representing the most prevalent metastatic pattern and primary contributor to CRC-related d…
-
ncRNA-Mediated Upregulation of AURKA Promotes Hepatocellular Carcinoma Progression and Alters the Immune Microenvironment.
Hepatocellular carcinoma (HCC) remains a major cause of cancer-related mortality worldwide. Aurora kinase A (AURKA), a critical regulator of mitosis and spindle assembly, has been implicated in tumorigenesis, yet its clinical relevance and …
- Hot on the TRAIL: Targeting SPHK1 in Colorectal Cancer: Therapeutic Potential of PF-543.
-
The Impact of Spatiotemporal Patterns of Tumor Recurrence on Prognosis in Hepatocellular Carcinoma Patients Undergoing Surgery After Conversion Therapy.
[PURPOSE] To characterize the spatiotemporal patterns of recurrence and assess their impact on survival in hepatocellular carcinoma (HCC) patients undergoing curative resection after conversion therapy. [METHODS] We retrospectively analyze…
-
Impact of MMR status on preoperative CT-based lymph node overstaging in right-sided colon cancer: a retrospective analysis.
[BACKGROUND] Neoadjuvant treatment for colon cancer has recently gained more and more attention. Given the imprecision of radiologic staging, low-risk patients may be exposed to the toxicities and inconvenience of chemotherapy when surgery …
-
Systemic Glucocorticoid Use and Risk of Colorectal Cancer, Especially Early-Onset Type: A Nationwide Cohort Study.
[BACKGROUND] Evidence on the association between systemic glucocorticoid use and colorectal cancer (CRC) risk is limited. This study aimed to determine whether systemic glucocorticoid use is associated with an increased risk of overall CRC …