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Survival and prognostic features of early-stage diffuse large B-cell lymphoma in older adults.
[BACKGROUND] Early-stage diffuse large B-cell lymphoma (ESDLBCL) in older adults is understudied, and existing prognostic tools such as the stage-adjusted International Prognostic Index (Sa-IPI) may not adequately account for comorbidity an…
FULLTEXT: method validation -
Identification of the immune-related diagnostic biomarkers between Graves' disease and thyroid carcinoma based on comprehensive bioinformatics analysis and machine learning.
Increasing evidence suggests that Graves' disease (GD) may increase the risk of thyroid cancer (THCA), but diagnostic biomarkers associated with it remain underexplored. To address this issue, we analyzed the Gene Expression Omnibus (GEO) a…
FULLTEXT: method validation -
Development and validation of a nomogram for the overall survival of patients with locally advanced prostate cancer treated with radiotherapy and surgery.
[BACKGROUND] Prostate cancer (PC) is a common malignancy in older adults. We aimed to construct a nomogram for the overall survival (OS) of elderly patients with locally advanced PC who received radiotherapy and surgery. [METHODS] Clinical…
FULLTEXT: method validation -
Immune-mediated pathways between red blood cell traits and prostate cancer: a causal relationship network based on Mendelian randomization evaluation.
[BACKGROUND] Although both the immune and hematopoietic systems play important roles in prostate cancer (PCa), few studies have comprehensively investigated the combined influence of these systems on PCa risk. [METHOD] The datasets used to…
FULLTEXT: method validation -
Development and validation of machine learning prognostic models for overall survival in non-surgical prostate cancer patients with bone metastases.
[OBJECTIVE] To construct and interpret a machine learning model for predicting overall survival in nonsurgical prostate cancer with bone metastases (PCBM). [METHODS] Data from 3,378 SEER database patients were utilized to develop machine l…
FULLTEXT: method validation -
The distinct roles of and in proximal- and late-onset colorectal cancer.
Despite the emerging role of the gut microbiome in colorectal cancer (CRC), its significance in early-onset CRC (EOCRC, …
FULLTEXT: method validation -
Full-length 16S rRNA nanopore sequencing enables species resolution of associated with colorectal cancer.
Recent studies have revealed that the long-recognized link between the historically defined group and colorectal cancer is largely driven by . This species, along with two others ( and ), was recently reclassified as distinct from , highli…
FULLTEXT: method validation -
Molecular mechanisms and therapeutic strategies: DNA methylation in pancreatic cancer.
[OBJECTIVE] This narrative review examines DNA methylation dysregulation in pancreatic cancer, focusing on its mechanistic roles in tumorigenesis and applications in biomarkers and therapies. [METHODS] We analyzed experimental and clinical…
FULLTEXT: method validation -
Clinical and nutritional-inflammatory biomarkers-based nomogram predicts survival in recurrent or metastatic cervical cancer treated with immune checkpoint inhibitors.
[BACKGROUND] Immunotherapy offers potential benefits for recurrent or metastatic cervical cancer (R/M CC), yet personalized predictive tools are essential for optimizing treatment. This study aims to develop a nomogram integrating nutrition…
FULLTEXT: method validation -
Leukemia-derived exosomes induce immunosuppression of dendritic cell function via TGFB2-MRPL58 axis.
[OBJECTIVES] To elucidate the mechanisms by which leukemia-derived exosomes induce immunosuppression in dendritic cells (DCs) and identify potential therapeutic targets. [METHODS] The optimal exosome dosage (20 µg/ml) for DC treatment was …
FULLTEXT: method validation -
Apoptosis-related genes influence prognosis and immune characteristics of diffuse large B-cell lymphoma.
[OBJECTIVES] Dysregulation of apoptosis-related genes (ARGs) may contribute to tumorigenesis and impact patient prognosis, but their specific influence on prognosis and immune characteristics in diffuse large B-cell lymphoma (DLBCL) remains…
FULLTEXT: method validation -
Phase angle as a nutritional assessment method in patients with acute myeloid leukemia: a cross-sectional study.
[BACKGROUND AND OBJECTIVES] The phase angle, which is associated with cellular health, has garnered increasing attention as a noninvasive and objective method for nutritional assessment. However, the association between malnutrition and pha…
FULLTEXT: method validation -
Health state utilities for relapsed or refractory large B-cell lymphoma treatments: a time trade-off study in the Japanese general population.
[AIM] Conventional therapies in Japan for relapsed or refractory large B-cell lymphoma (r/r LBCL) require intravenous infusion (IV), while epcoritamab is administered subcutaneously. Despite the expected quality of life (QOL) improvement fr…
FULLTEXT: method validation -
Adaptive immune and platelet activation during the maintenance phase of therapy in adults with B cell acute lymphoblastic leukemia.
[BACKGROUND] Maintenance therapy is an integral component of treatment for B cell acute lymphoblastic leukemia (B-ALL) and has demonstrated clinical efficacy. However, features of immune activation and an increased thrombotic risk may persi…
FULLTEXT: method validation -
NAD precursor supplementation reverses CD36-mediated lipid accumulation and ferroptosis to restore antitumor function of NK cells in DLBCL.
Natural killer (NK) cells play a key role in the standard treatment of diffuse large B-cell lymphoma (DLBCL). However, NK cells in DLBCL patients frequently display an exhausted phenotype, which is associated with poor clinical outcomes. Th…
FULLTEXT: method validation -
Mutations in CHIP-associated genes at myeloid neoplasm diagnosis and risk of cardiovascular/cerebrovascular events.
[BACKGROUND] Clonal hematopoiesis of indeterminate potential (CHIP)-associated somatic mutations are associated with increased cardiovascular and cerebrovascular risk in the general population; whether mutations detected at myeloid neoplasm…
FULLTEXT: method validation -
TNS1 and TNS4 play a potential role in development of pancreatic ductal adenocarcinoma but not TNS2 and TNS3.
Tensins are a family of adhesion proteins that play a role in constructing the cytoskeleton, as well as in intracellular and extracellular communication. Their expression was evaluated in 22 pancreatic cancer patients using the immunohistoc…
FULLTEXT: method validation -
Pre-ablation stimulated thyroglobulin to TSH ratio as a strong predictor of non-generally satisfactory response to initial radioiodine therapy in papillary thyroid carcinoma patients undergoing lateral neck dissection.
[BACKGROUND] The initial response to radioiodine (³I) therapy is a critical determinant of prognosis in papillary thyroid carcinoma (PTC) patients undergoing therapeutic lateral neck dissection (LND). This study aimed to identify predictors…
FULLTEXT: method validation -
Diagnostic performance and generalizability of a clinical-ultrasound radiomics model for predicting extrathyroidal extension in thyroid carcinoma: a retrospective study.
[BACKGROUND] Ultrasound plays a crucial role in the preoperative evaluation of thyroid carcinoma and its extrathyroidal extension (ETE). This study aims to develop and validate a model integrating ultrasound radiomics and clinical factors f…
FULLTEXT: method validation -
Durable response of anaplastic thyroid cancer to pembrolizumab combined with chemotherapy: A case report.
Anaplastic thyroid cancer is a notoriously aggressive malignancy with a dismal prognosis, typically associated with a median overall survival of less than one year. Therapeutic alternatives are particularly limited for patients without acti…
FULLTEXT: method validation