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[BACKGROUND] Early-stage diffuse large B-cell lymphoma (ESDLBCL) in older adults is understudied, and existing prognostic tools such as the stage-adjusted International Prognostic Index (Sa-IPI) may not adequately account for comorbidity an…

Increasing evidence suggests that Graves' disease (GD) may increase the risk of thyroid cancer (THCA), but diagnostic biomarkers associated with it remain underexplored. To address this issue, we analyzed the Gene Expression Omnibus (GEO) a…

[BACKGROUND] Prostate cancer (PC) is a common malignancy in older adults. We aimed to construct a nomogram for the overall survival (OS) of elderly patients with locally advanced PC who received radiotherapy and surgery. [METHODS] Clinical…

[BACKGROUND] Although both the immune and hematopoietic systems play important roles in prostate cancer (PCa), few studies have comprehensively investigated the combined influence of these systems on PCa risk. [METHOD] The datasets used to…

[OBJECTIVE] To construct and interpret a machine learning model for predicting overall survival in nonsurgical prostate cancer with bone metastases (PCBM). [METHODS] Data from 3,378 SEER database patients were utilized to develop machine l…

Despite the emerging role of the gut microbiome in colorectal cancer (CRC), its significance in early-onset CRC (EOCRC, …

Recent studies have revealed that the long-recognized link between the historically defined group and colorectal cancer is largely driven by . This species, along with two others ( and ), was recently reclassified as distinct from , highli…

[OBJECTIVE] This narrative review examines DNA methylation dysregulation in pancreatic cancer, focusing on its mechanistic roles in tumorigenesis and applications in biomarkers and therapies. [METHODS] We analyzed experimental and clinical…

[BACKGROUND] Immunotherapy offers potential benefits for recurrent or metastatic cervical cancer (R/M CC), yet personalized predictive tools are essential for optimizing treatment. This study aims to develop a nomogram integrating nutrition…

[BACKGROUND] Bruton tyrosine kinase inhibitors (BTKis) are therapeutic agents for relapsed/refractory chronic lymphocytic leukemia (R/R CLL). Previous indirect treatment comparisons are limited in simultaneously comparing multiple intervent…

[OBJECTIVES] To elucidate the mechanisms by which leukemia-derived exosomes induce immunosuppression in dendritic cells (DCs) and identify potential therapeutic targets. [METHODS] The optimal exosome dosage (20 µg/ml) for DC treatment was …

[OBJECTIVES] Dysregulation of apoptosis-related genes (ARGs) may contribute to tumorigenesis and impact patient prognosis, but their specific influence on prognosis and immune characteristics in diffuse large B-cell lymphoma (DLBCL) remains…

[BACKGROUND AND OBJECTIVES] The phase angle, which is associated with cellular health, has garnered increasing attention as a noninvasive and objective method for nutritional assessment. However, the association between malnutrition and pha…

[AIM] Conventional therapies in Japan for relapsed or refractory large B-cell lymphoma (r/r LBCL) require intravenous infusion (IV), while epcoritamab is administered subcutaneously. Despite the expected quality of life (QOL) improvement fr…

[BACKGROUND] The treatment strategy for intestinal non-Hodgkin lymphoma (NHL) and the role of surgery warrant reevaluation. [METHODS] This study analyzed clinical data from a cohort of 12,047 patients diagnosed with intestinal NHL, extract…

[BACKGROUND] Maintenance therapy is an integral component of treatment for B cell acute lymphoblastic leukemia (B-ALL) and has demonstrated clinical efficacy. However, features of immune activation and an increased thrombotic risk may persi…

Natural killer (NK) cells play a key role in the standard treatment of diffuse large B-cell lymphoma (DLBCL). However, NK cells in DLBCL patients frequently display an exhausted phenotype, which is associated with poor clinical outcomes. Th…

[BACKGROUND] Clonal hematopoiesis of indeterminate potential (CHIP)-associated somatic mutations are associated with increased cardiovascular and cerebrovascular risk in the general population; whether mutations detected at myeloid neoplasm…

Tensins are a family of adhesion proteins that play a role in constructing the cytoskeleton, as well as in intracellular and extracellular communication. Their expression was evaluated in 22 pancreatic cancer patients using the immunohistoc…

[BACKGROUND] The initial response to radioiodine (³I) therapy is a critical determinant of prognosis in papillary thyroid carcinoma (PTC) patients undergoing therapeutic lateral neck dissection (LND). This study aimed to identify predictors…