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An exploratory serum metabolomics study for screening and staging of breast cancer.
[OBJECTIVE] This study investigates serum metabolic profiles in breast cancer to identify diagnostic biomarkers and stage-specific metabolites, offering insights for clinical practice. [METHODS] Gas chromatography‒mass spectrometry (GC‒MS)…
FULLTEXT: Bayesian dynamic borrowing -
Polymersome-based nanomedicine for combined cancer therapy.
Cancer is a complex disease characterized by uncontrolled cell growth and spread, often resulting in metastasis. The use of combination therapy, which involves the simultaneous application of two or more treatment methods, aims to enhance e…
FULLTEXT: Bayesian dynamic borrowing -
B cells and humoral immunity in melanoma: regulatory and autoimmune-like features and implications for immunotherapy.
B cells and the humoral immune response are increasingly recognized as critical modulators of melanoma progression and immunotherapy outcomes. While checkpoint inhibitor (CPI) therapy was developed to target T cell exhaustion mechanisms, em…
FULLTEXT: Bayesian dynamic borrowing -
Dynamic changes in cellular mechanics and membrane microviscosity during migration of colorectal cancer cells.
The ability of tumor cells to migrate and invade adjacent tissue is a key property underlying the metastatic process. To ensure greater deformability and to facilitate movement, migratory cells undergo multiple changes in biophysical parame…
FULLTEXT: Bayesian dynamic borrowing -
Abnormal expansion of peripheral helper T cells in primary immune thrombocytopenia.
Peripheral helper T (Tph) cells, a distinct T-cell subset defined as CD4PD-1CXCR5 phenotypically, are increasingly recognized as key drivers of antibody-mediated autoimmunity; however, their role in primary immune thrombocytopenia (ITP) rem…
FULLTEXT: Bayesian dynamic borrowing -
A longitudinal study of supportive care needs among Chinese parents of children with acute lymphoblastic leukemia.
[OBJECTIVE] To determine parents' supportive care needs trajectories over the first 8 months following their children's diagnosis and identify the predictors of these trajectories. [METHODS] Overall, 100/112 Chinese parents of children new…
FULLTEXT: Bayesian dynamic borrowing -
The role of mesencephalic astrocyte-derived neurotrophic factor in digestive diseases.
[BACKGROUND] Mesencephalic astrocyte-derived neurotrophic factor (MANF) is an evolutionarily conserved endoplasmic reticulum (ER)-resident and secreted protein highly expressed in the digestive system. Emerging evidence has highlighted its …
FULLTEXT: Bayesian dynamic borrowing -
DA-LUNGNET: a multi-stage deep framework with adaptive attention for early detection of subcentimeter pulmonary nodules.
Early and reliable detection of subcentimeter pulmonary nodules remains a major bottleneck in low-dose CT-based lung cancer screening due to high miss rates, vascular-adhesion-induced false positives, and insufficient multi-scale feature fu…
FULLTEXT: Bayesian dynamic borrowing -
Neuroimmune circuits in respiratory pathophysiology: decoding molecular crosstalk for precision therapeutic targeting.
[BACKGROUND] The lung is a uniquely innervated barrier organ with dynamic neuroimmune interactions that critically regulate respiratory homeostasis. Despite the well-characterized gut-brain axis, pulmonary neuroimmune crosstalk remains an u…
FULLTEXT: Bayesian dynamic borrowing -
Geographic disparities and health inequality evolution in the disease burden of tracheal, bronchus, and lung cancer in Asia: a 33-year longitudinal analysis and future projections.
[OBJECTIVE] This study examined geographic patterns, temporal trends, and determinants of tracheal, bronchus, and lung (TBL) cancer burden in Asia (1990-2023), evaluated disparities in health outcomes, and developed projections for targeted…
FULLTEXT: Bayesian dynamic borrowing -
Decision-making processes among patients with lung cancer considering participation in neoadjuvant immunotherapy clinical trials: A qualitative grounded theory study.
[OBJECTIVE] As neoadjuvant immunotherapy becomes increasingly incorporated into clinical trial protocols for lung cancer, patients are required to make complex decisions under conditions of uncertainty. However, the dynamic processes underl…
FULLTEXT: Bayesian dynamic borrowing -
Axillary treatment options in clinically nodes-positive breast cancer whose nodes become pathologically nodes-negative after neoadjuvant chemotherapy: a pairwise and network meta-analysis.
[BACKGROUND] Neoadjuvant chemotherapy (NAC) has increased heterogeneity in regional axillary management. The optimal strategy remains uncertain for patients with clinically node-positive (cN+) breast cancer (BC) who convert to pathologicall…
FULLTEXT: Bayesian dynamic borrowing -
A system-level metastable model of cancer evolution: integrating replication stress, cell cycle deregulation and chromosomal instability.
[INTRODUCTION] Cancer cell proliferation occurs within the context of persistent genomic instability. In this review, we propose the RS-CCD-CIN axis as a systems-level framework in which replication stress (RS), cell cycle deregulation (CCD…
FULLTEXT: Bayesian dynamic borrowing -
Synergistic immune interactions between T cells and natural killer cells in allogeneic haematopoietic stem cell transplantation for acute myeloid leukaemia: current status and future directions.
[BACKGROUND] Acute myeloid leukaemia (AML) is a highly heterogeneous haematologic malignancy. Current therapeutic strategies include chemotherapy, targeted therapy and haematopoietic cell transplantation (allo-HSCT) and autologous haematopo…
FULLTEXT: Bayesian dynamic borrowing -
Molecular targeted therapy in combination with chemotherapy for the treatment of platinum-resistant/refractory ovarian cancer (PROC): a systematic review and network meta-analysis.
[BACKGROUND] Although single-agent chemotherapy is the most common approach for treating platinum-resistant or refractory ovarian cancer (PROC), there is growing evidence that combining molecular targeted agents with chemotherapy is benefic…
FULLTEXT: Bayesian dynamic borrowing -
Comparative effects of pharmacological interventions in the prophylactic treatment of tension-type headache: systematic review and network meta-analysis.
TL;DRAmitriptyline 100 mg and BTX-A 100 U may be options to reduce monthly headache days in patients with chronic TTH given the low to very low certainty of evidence, high risk of bias, and high heterogeneity.
FULLTEXT: Bayesian dynamic borrowing -
Dual-lock gated DNAzyme-CRISPR cascade for amplification-free ultrasensitive profiling of FTO demethylase activity.
N6-methyladenosine, the most prevalent internal mRNA modification in eukaryotes, dynamically regulates transcriptomic homeostasis via FTO-mediated demethylation. CRISPR-based FTO detection technologies represent a significant research direc…
FULLTEXT: Bayesian dynamic borrowing -
Ultrasensitive and rapid lateral flow biosensor based on exponential rolling circle amplification for the detection of cancer biomarkers.
This study reports a structurally optimized exponential rolling circle amplification (ERCA)-lateral flow assay (LFA) platform that achieves ultrafast and ultrasensitive nucleic acid detection for cancer biomarker diagnosis. By engineering a…
FULLTEXT: Bayesian dynamic borrowing -
Global burden, temporal trends and cross-national inequalities of the comorbidity between depressive disorder and hormone-dependent tumors in women of reproductive ages from 1990 to 2021: A population-based analysis with projections to 2036.
[BACKGROUND] This study aimed to analyze the global comorbidity burden of depressive disorder (DD) and hormone-dependent tumors (HDTs), including breast cancer (BC), ovarian cancer (OC), and uterine cancer (UC), among women of reproductive …
FULLTEXT: Bayesian dynamic borrowing -
Design, synthesis, and mechanistic study of bispecific small molecules-based phenyl pyrazolopyrimidinone scaffold as dual-targeting VEGFR and PD-L1 immune checkpoint in hepatocellular carcinoma.
In this work, a new series of N-arylmethylene/heterylmethylene-2-(4-oxo-1-phenyl-1,4-dihydro-5H-pyrazolo[3,4-d]pyrimidin-5-yl)acetohydrazide 8a-l was synthesized via the condensation reaction of acetohydrazide 6 with various aromatic aldehy…
FULLTEXT: Bayesian dynamic borrowing