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An exploratory serum metabolomics study for screening and staging of breast cancer.
[OBJECTIVE] This study investigates serum metabolic profiles in breast cancer to identify diagnostic biomarkers and stage-specific metabolites, offering insights for clinical practice. [METHODS] Gas chromatography‒mass spectrometry (GC‒MS)…
FULLTEXT: Bayesian dynamic borrowing randomized -
Polymersome-based nanomedicine for combined cancer therapy.
Cancer is a complex disease characterized by uncontrolled cell growth and spread, often resulting in metastasis. The use of combination therapy, which involves the simultaneous application of two or more treatment methods, aims to enhance e…
FULLTEXT: Bayesian dynamic borrowing randomized -
B cells and humoral immunity in melanoma: regulatory and autoimmune-like features and implications for immunotherapy.
B cells and the humoral immune response are increasingly recognized as critical modulators of melanoma progression and immunotherapy outcomes. While checkpoint inhibitor (CPI) therapy was developed to target T cell exhaustion mechanisms, em…
FULLTEXT: Bayesian dynamic borrowing randomized -
Dynamic changes in cellular mechanics and membrane microviscosity during migration of colorectal cancer cells.
The ability of tumor cells to migrate and invade adjacent tissue is a key property underlying the metastatic process. To ensure greater deformability and to facilitate movement, migratory cells undergo multiple changes in biophysical parame…
FULLTEXT: Bayesian dynamic borrowing randomized -
Abnormal expansion of peripheral helper T cells in primary immune thrombocytopenia.
Peripheral helper T (Tph) cells, a distinct T-cell subset defined as CD4PD-1CXCR5 phenotypically, are increasingly recognized as key drivers of antibody-mediated autoimmunity; however, their role in primary immune thrombocytopenia (ITP) rem…
FULLTEXT: Bayesian dynamic borrowing randomized -
A longitudinal study of supportive care needs among Chinese parents of children with acute lymphoblastic leukemia.
[OBJECTIVE] To determine parents' supportive care needs trajectories over the first 8 months following their children's diagnosis and identify the predictors of these trajectories. [METHODS] Overall, 100/112 Chinese parents of children new…
FULLTEXT: Bayesian dynamic borrowing randomized -
Prolonged progression-free survival with zanubrutinib in relapsed/refractory CLL: an indirect treatment comparison versus other BTK inhibitors using multilevel network meta-regression.
[BACKGROUND] Bruton tyrosine kinase inhibitors (BTKis) are therapeutic agents for relapsed/refractory chronic lymphocytic leukemia (R/R CLL). Previous indirect treatment comparisons are limited in simultaneously comparing multiple intervent…
FULLTEXT: Bayesian dynamic borrowing randomized -
The surgery for the patients with intestinal non‑Hodgkin lymphomas: a nationwide study.
[BACKGROUND] The treatment strategy for intestinal non-Hodgkin lymphoma (NHL) and the role of surgery warrant reevaluation. [METHODS] This study analyzed clinical data from a cohort of 12,047 patients diagnosed with intestinal NHL, extract…
FULLTEXT: Bayesian dynamic borrowing randomized -
A Randomized Trial Evaluating Intraoperative Ischemic Preconditioning of Parathyroid Glands During Total Thyroidectomy: A Signal for Earlier Parathyroid Function Recovery.
[BACKGROUND] Ischemic preconditioning of parathyroid glands (IPCP) is biologically plausible but clinical evidence is limited. In this single-center randomized trial (ChiCTR2000039788), we compared IPCP versus control during total thyroidec…
FULLTEXT: Bayesian dynamic borrowing randomized -
Comparison of the effects of exercise-based interventions on cardiometabolic health and fatigue in men with prostate cancer receiving androgen deprivation therapy: A network meta-analysis.
[OBJECTIVE] To compare the effects of exercise-based interventions on cardiometabolic health and fatigue in men with prostate cancer receiving androgen deprivation therapy (ADT). [METHODS] A comprehensive search for Randomized controlled s…
FULLTEXT: Bayesian dynamic borrowing randomized -
The role of mesencephalic astrocyte-derived neurotrophic factor in digestive diseases.
[BACKGROUND] Mesencephalic astrocyte-derived neurotrophic factor (MANF) is an evolutionarily conserved endoplasmic reticulum (ER)-resident and secreted protein highly expressed in the digestive system. Emerging evidence has highlighted its …
FULLTEXT: Bayesian dynamic borrowing randomized -
Impact of offering blood-based testing alongside existing modalities for colorectal cancer screening among those who previously declined screening: an economic evaluation.
[AIM] Inadequate adherence to colorectal cancer screening reduces individual and population level health benefits. Blood-based tests offer a new modality that may help patients overcome barriers, but there are concerns about the impact of p…
FULLTEXT: Bayesian dynamic borrowing randomized -
DA-LUNGNET: a multi-stage deep framework with adaptive attention for early detection of subcentimeter pulmonary nodules.
Early and reliable detection of subcentimeter pulmonary nodules remains a major bottleneck in low-dose CT-based lung cancer screening due to high miss rates, vascular-adhesion-induced false positives, and insufficient multi-scale feature fu…
FULLTEXT: Bayesian dynamic borrowing randomized -
Neuroimmune circuits in respiratory pathophysiology: decoding molecular crosstalk for precision therapeutic targeting.
[BACKGROUND] The lung is a uniquely innervated barrier organ with dynamic neuroimmune interactions that critically regulate respiratory homeostasis. Despite the well-characterized gut-brain axis, pulmonary neuroimmune crosstalk remains an u…
FULLTEXT: Bayesian dynamic borrowing randomized -
Patient-reported outcomes with a personalized follow-up program after lung cancer resection: A single-center randomized controlled trial.
[OBJECTIVE] This study aims to determine the impact of PROM with a personalized follow-up program on the evaluation of quality of life and self-management for patients after lung cancer resection. [METHODS] Given a formal power calculation…
FULLTEXT: Bayesian dynamic borrowing randomized -
Geographic disparities and health inequality evolution in the disease burden of tracheal, bronchus, and lung cancer in Asia: a 33-year longitudinal analysis and future projections.
[OBJECTIVE] This study examined geographic patterns, temporal trends, and determinants of tracheal, bronchus, and lung (TBL) cancer burden in Asia (1990-2023), evaluated disparities in health outcomes, and developed projections for targeted…
FULLTEXT: Bayesian dynamic borrowing randomized -
Cost-effectiveness of pembrolizumab plus chemotherapy for metastatic non-small cell lung cancer: a head-to-head trial vs. real-world comparison.
[OBJECTIVES] Real-world evidence (RWE) is increasingly used in health technology assessment (HTA) to address uncertainties surrounding the generalizability of randomized clinical trial (RCT) data. Pembrolizumab plus platinum-based chemother…
FULLTEXT: Bayesian dynamic borrowing randomized -
Decision-making processes among patients with lung cancer considering participation in neoadjuvant immunotherapy clinical trials: A qualitative grounded theory study.
[OBJECTIVE] As neoadjuvant immunotherapy becomes increasingly incorporated into clinical trial protocols for lung cancer, patients are required to make complex decisions under conditions of uncertainty. However, the dynamic processes underl…
FULLTEXT: Bayesian dynamic borrowing randomized -
Managing psychological distress in women with breast cancer: A systematic review of intervention trends in the past decade.
[OBJECTIVE] The rising incidence and survival rates of breast cancer have increased the number of breast cancer survivors (BCSs) experiencing psychological distress that often overlaps with anxiety, depression, and fear of recurrence. Many …
FULLTEXT: Bayesian dynamic borrowing randomized -
Axillary treatment options in clinically nodes-positive breast cancer whose nodes become pathologically nodes-negative after neoadjuvant chemotherapy: a pairwise and network meta-analysis.
[BACKGROUND] Neoadjuvant chemotherapy (NAC) has increased heterogeneity in regional axillary management. The optimal strategy remains uncertain for patients with clinically node-positive (cN+) breast cancer (BC) who convert to pathologicall…
FULLTEXT: Bayesian dynamic borrowing randomized