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Spiky Nanoparticle-Gel Composite for Efficient Intravesical Botulinum Toxin A Delivery and Treatment of Overactive Bladder.
Overactive bladder (OAB) is a symptomatic disease that is difficult to treat. This study developed APTES-functionalized spiky titanium dioxide nanoparticles (ASNPs) loaded with botulinum toxin A (ASNP@BA), which is coated with P407/HA (HP) …
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Single-port Non-liposuction Endoscopic Axillary Lymph Node Dissection in Breast Cancer Surgery.
Breast cancer is the most common malignant tumor among women worldwide. For patients with a high axillary lymph node burden, axillary lymph node dissection (ALND) remains an essential component of surgical management; however, its associate…
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Association between neuroticism and cosmetic mammoplasty: Results from a bidirectional Mendelian randomization study.
Observational studies have suggested associations between neuroticism and the tendency to undergo cosmetic mammoplasty, but their causal relationships remain unclear. Our study aimed to assess the causal associations between neuroticism and…
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Compliant, Tough, Fatigue-Resistant, and Biocompatible PHEMA-Based Hydrogels as a Breast Implant Material.
Breast reconstruction remains hindered by the limitations of conventional implant materials such as silicone, which exhibit hydrophobicity and poor tissue integration, often leading to complications, including capsular contracture. Here, we…
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Neoadjuvant chemoimmunotherapy brings superior quality of life of patients with locally advanced oral or oropharyngeal cancer: A propensity score-matched analysis.
[BACKGROUND] The outcomes and quality of life of patients with locally advanced oral or oropharyngeal squamous cell carcinoma (LAOOPSCC) following upfront surgery (US) are suboptimal. The optimal neoadjuvant therapy involving programmed dea…
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Individual surgical management of trigeminal schwannomas guided by an extended classification: a consecutive series of 96 clinical cases at a single institution.
Trigeminal schwannoma (TS) is a rare intracranial neurinoma that affects the multicompartmental skull base. In recent decades, advancements in skull-base neurosurgical techniques and endoscopic surgery have significantly improved outcomes f…
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The Assessment, Strategy, and Treatment Protocol: Nasolabial Fold Assessment, Strategy, and Treatment With Hyaluronic Acid Fillers in Chinese Patients.
[BACKGROUND] Causes contributing to nasolabial fold (NLF) appearance can be multifactorial, hence requiring distinct dermal filler strategies. We devised 4 assessment, strategy, and treatment (AST) injection protocols, incorporating NLF eti…
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Advancements in the management of overactive bladder in women using nano-botulinum toxin type A: A narrative review.
Intravesical injections of botulinum toxin type A (BTX-A) are effective for treating refractory overactive bladder (OAB) in women. However, the adverse effects linked to the injections, such as hematuria, pain, and infection, and need for r…
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Safety and efficacy of intravesical instillation of botulinum toxin-A in the treatment of interstitial cystitis/bladder pain syndrome and overactive bladder: a systematic review and meta-analysis.
[BACKGROUND] The effectiveness and safety of the instillation of botulinum toxin A (BTX-A) remain subjects of controversy. The meta-analysis was performed to assess the efficacy and safety of a novel intravesical instillation of BTX-A for m…
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Engineered Exosomes Complexed with Botulinum Toxin Type A for Enhanced Anti-Aging Effects on Skin.
Skin aging is commonly characterized by increased wrinkles, loss of elasticity, and hyperpigmentation, significantly affecting personal appearance and quality of life. Although botulinum toxin type A (BTX-A) has been widely applied in cosme…
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Enhancing Mid-Upper Facial Contours: Hairline Transplant Solutions for East Asian Women With High and Wide Foreheads.
[BACKGROUND] A high and wide forehead is a common congenital facial characteristic among East Asian women, often resulting in an imbalanced mid-upper facial proportion, diminished three-dimensional contour, and reduced femininity. Although …
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A Comparison of 3 Minimally Invasive Surgeries for Treating Axillary Osmidrosis.
[BACKGROUND] Axillary osmidrosis is a common cause of physical and social discomfort. Although many treatments are available, there is still room for improvement. [OBJECTIVE] For treatments of axillary osmidrosis 3 minimally invasive surgi…
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Optimal Strategies for Autologous Fat Grafting in Breast Augmentation and Reconstruction: A Systematic Review and Network Meta-Analysis.
[BACKGROUND] Cell-assisted lipotransfer (CAL) and platelet-rich plasma (PRP)-assisted lipotransfer have been used to overcome the low survival rate of conventional lipotransfer. However, there is still insufficient evidence to determine whi…
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Breast Augmentation with Inferior Muscular Support: The Indication, Technique Evolution, and Outcomes.
Smooth implants, favored for their lower risk of rupture and BIA-ALCL, encounter stability challenges in preventing implant displacement and bottoming out. Therefore, a stronger support of the lower pole is necessary to immobilize the impla…
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A Modified Bimuscular Flap Technique for Breast Augmentation: Does Extra Muscle Support Enhance the Stability of Smooth Implants?
[BACKGROUND] Because of concerns related to breast implant-associated anaplastic large-cell lymphoma, smooth implants are being increasingly used instead of textured breast implants. However, lack of sufficient lower-pole support for smooth…
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Application of Hyaluronic Acid Linear Stereoscopic Stack Volume Enhancement Injection Technique in Nasal Reshaping.
Hyaluronic acid (HA) injection, traditionally used for non-surgical rhinoplasty, is often associated with adverse effects such as increased nasal dorsum width. This study introduces the linear stereoscopic stack volume enhancement (LSSVE) i…
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Diced Cartilage Grafts Semi-wrapped in Rectus Abdominis Fascia for Nasal Dorsum Augmentation.
[BACKGROUND] Diced costal cartilage wrapped in autogenous fascia is favored by rhinoplasty surgeons because of its high stability and low resorption rate. However, the volume of fascial bags is difficult to adjust, and diced costal cartilag…
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Intravesical injection of botulinum toxin type a may be an effective treatment option for autonomic dysreflexia in patients with high-level spinal cord injury.
[OBJECTIVE] To evaluate the efficacy of intravesical injection of botulinum toxin type A (BTX-A) for neurogenic detrusor overactivity (DO) in reducing the frequency and severity of autonomic dysreflexia (AD). [DESIGN] A cross-sectional non…
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Isolation and anti-neuroinflammation activity of sesquiterpenoids from Artemisia argyi: computational simulation and experimental verification.
[BACKGROUND] Artemisia argyi is a traditional herbal medicine belonging to the genus Artemisia that plays an important role in suppressing inflammation. However, the chemical constituents and underlying mechanisms of its therapeutic potenti…
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Rac1 promotes the lipopolysaccharide-induced inflammatory response and contraction-associated proteins (CAPs) expression in mouse uterine smooth muscle cells.
Activation of the maternal immune system leads to a downstream cascade of proinflammatory events that culminate in the activation of spontaneous uterine contractions, which is associated with preterm birth. Ras-related C3 botulinum toxin su…
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DaxibotulinumtoxinA for injection to treat moderate or severe glabellar lines: A randomized, multicenter, Phase III, double-blind, placebo-controlled trial in China.
[BACKGROUND] DaxibotulinumtoxinA for injection (DAXI), a novel botulinum toxin type A formulation, is FDA-approved for glabellar lines treatment. Its clinical efficacy has been demonstrated in two Phase III trials (SAKURA 1 and SAKURA 2). …
- A novel method to clean hair follicular grafts in hair transplantation.
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A Comparative Study on the Application of Robotic Hair Restoration Technology Versus Traditional Follicular Unit Excision in Male Androgenetic Alopecia.
[BACKGROUND] The robotic hair transplant technology, ARTAS, has a series of fine mechanical structure and an intelligent recognition system that allows it to independently select hair follicular units (FUs) and effectively harvest hair. Aft…
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Exploring the landscape of extracellular vesicle application for skin and plastic surgery: A bibliometric analysis from 2003 to 2023.
[BACKGROUND] Exosomes and other secretory membrane vesicles, collectively referred to as extracellular vesicles (EVs), have garnered increasing attention in research due to their biological characteristics. Notably, studies have shown promi…
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Preservation of the integrity of facial nerve in vestibular schwannoma microsurgery: A consecutive study of 127 clinical cases focusing on nervus intermedius.
[BACKGROUND] Nervus intermedius (NI) injuries are not given enough attention by neurosurgeons during vestibular schwannoma (VS) surgery. Preservation of NI function is essential for the integrity and continuity of the facial nerve, although…
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Efficacy and Safety of AbobotulinumtoxinA for the Treatment of Glabellar Lines in Chinese Patients: A Pivotal, Phase 3, Randomized, Double-Blind and Open-Label Phase Study.
[BACKGROUND] Various botulinumtoxinA formulations are approved for glabellar lines treatment worldwide, including abobotulinumtoxinA (Dysport). [OBJECTIVES] Assess abobotulinumtoxinA superiority versus placebo and non-inferiority versus ac…
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Rac1 promotes the reprogramming of glucose metabolism and the growth of colon cancer cells through upregulating SOX9.
Metabolic reprogramming is the survival rule of tumor cells, and tumor cells can meet their high metabolic requirements by changing the energy metabolism mode. Metabolic reprogramming of tumor cells is an important biochemical basis of tumo…
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Ultrasound-assisted intravesical botulinum toxin A delivery attenuates acetic acid-induced bladder hyperactivity in rats.
Intradetrusor injection of botulinum toxin A (BTX-A) is an effective treatment for overactive bladder (OAB). However, the occurrence of adverse events associated with BTX-A injection therapy hinders its acceptance among patients and its cli…
- The ring cup used for reducing hair follicle loss in hair transplantation.
- Investigation of oral finasteride enhanced occipital hair diameter index in different types of male androgenetic alopecia.