The autoimmune basis of alopecia areata: a comprehensive review.
💡 한 문장 핵심
원형 탈모의 자가면역적 기전: 종합적 고찰
5/5 보강
TL;DR
Recent studies suggest that intervention of the JAK pathway may have a potential therapeutic efficacy for AA, and multiple treatment options including the use of broad acting corticosteroids appear to be relatively effective in mild cases.
📑 코퍼스 인용 관계
· 인용됨 83
📑 인용한 논문 (6) ▾
- Responses to Tetanus and Meningococcal Vaccines in Patients with Alopecia Areata Treated w… Dermatology and therapy · 2026
- Dermatologists' Perspectives and Real-World Assessment of Alopecia Areata Severity in Adul… Dermatology and therapy · 2026
- Long-Term Efficacy and Safety of Ritlecitinib in Adults and Adolescents with Alopecia Area… American journal of clinical dermatology · 2026
- Is Spontaneous Regrowth in Alopecia Areata Possible: A Systematic Review and Meta-analysis… Acta dermato-venereologica · 2025
- LncRNA NEAT1 and miRNA 101 as potential diagnostic biomarkers in patients with alopecia ar… Non-coding RNA research · 2025
- Evaluation of Olive Oil-Based Formulations Loaded with Baricitinib for Topical Treatment o… Pharmaceutics · 2025
연도별 인용 (2015–2026) · 합계 255
OpenAlex 토픽 ·
Hair Growth and Disorders
RNA regulation and disease
Autoimmune Bullous Skin Diseases
🇰🇷 한글 요약 🌐 Abstract
【연구 목적】
원형 탈모증(alopecia areata, AA)의 자가면역학적 발병 기전을 종합적으로 정리하고, 임상 양상·병인·치료 옵션을 고찰하는 것이 목적입니다.
【방법】
AA의 자가면역 기전에 관한 기존 임상 연구 및 실험 연구를 종합한 문헌 고찰(comprehensive review) 형식으로 진행되었습니다.
【주요 결과】
AA는 모낭의 면역특권(immune privilege) 붕괴와 CD4+·CD8+ T세포 침윤, Th1 사이토카인 우세 반응이 핵심 기전으로 지목되며, 바이러스 감염·외상·유전적 소인도 관여합니다. 경증은 광범위 작용 코르티코스테로이드(corticosteroid)에 비교적 잘 반응하나 전두 탈모증(alopecia totalis)·범발성 탈모증(alopecia universalis) 등 중증은 치료가 어렵고, 최근 JAK 억제제(JAK inhibitor)가 유망한 치료 대안으로 제시됩니다.
【임상적 시사점 (성형외과 의사 관점)】
탈모 환자 상담 시 반흔성 탈모와 달리 AA는 비반흔성(non-scarring)이라 모낭이 보존되므로 모발이식보다 면역학적 약물 치료가 우선임을 감별·설명해야 합니다. 활동성 AA는 자가면역 활성 상태이므로 모발이식이나 두피 시술의 시기를 신중히 판단하고, 중증·난치성 환자는 JAK 억제제 등 전신 치료가 가능한 피부과와의 협진을 고려하는 것이 바람직합니다.
Alopecia areata (AA) is a common, non-scarring dermatologic condition regularly distinguished by patches of hair loss on the scalp also manifesting in other, severe forms, including alopecia totalis (total loss of hair on the scalp) and alopecia universalis (complete loss of hair on the scalp and body). AA is a clinically heterogeneous disease with greatly varying yet typical symptoms, but the etiology for AA remains an enigma. However, clinical and experimental studies have pointed to autoimmune involvement, specifically regarding immune privilege sites of the hair follicles and the infiltration of CD4+ and CD8+ T cells and a predominant Th1 cytokine profile. Environmental insults, such as viral infections, trauma and genetic predisposition are also believed to contribute to the disease process. Multiple treatment options including the use of broad acting corticosteroids appear to be relatively effective in mild cases, however the clinical management of more severe forms of AA is much more difficult. Recent studies suggest that intervention of the JAK pathway may have a potential therapeutic efficacy for AA.
【연구 목적】 원형 탈모증(alopecia areata, AA)의 자가면역학적 발병 기전을 종합적으로 정리하고, 임상 양상·병인·치료 옵션을 고찰하는 것이 목적입니다.
APA 7
Islam, N., Leung, P. S., Huntley, A. C., & Gershwin, M. E. (2015). The autoimmune basis of alopecia areata: A comprehensive review.. Autoimmunity reviews, 14(2), 81-9. https://doi.org/10.1016/j.autrev.2014.10.014
Vancouver
Islam N, Leung PS, Huntley AC, Gershwin ME. The autoimmune basis of alopecia areata: a comprehensive review. Autoimmunity reviews. 2015;14(2):81-9. doi:10.1016/j.autrev.2014.10.014
AMA 11
Islam N, Leung PS, Huntley AC, Gershwin ME. The autoimmune basis of alopecia areata: a comprehensive review. Autoimmunity reviews. 2015;14(2):81-9. doi:10.1016/j.autrev.2014.10.014
Chicago
Islam, N., Leung, P. S., Huntley, A. C., and Gershwin, M. E.. 2015. "The autoimmune basis of alopecia areata: a comprehensive review." Autoimmunity reviews 14 (2): 81-9. https://doi.org/10.1016/j.autrev.2014.10.014
MLA 9
Islam, N., et al. "The autoimmune basis of alopecia areata: a comprehensive review." Autoimmunity reviews, vol. 14, no. 2, 2015, pp. 81-9. doi:10.1016/j.autrev.2014.10.014.
PMID
25315746 ↗
추출된 의학 개체 (NER)
전체 NER 표 보기
| 유형 | 영어 표현 | 한국어 / 풀이 | UMLS CUI | 출처 | 등장 |
|---|---|---|---|---|---|
| 해부 | scalp
|
두피 | dict | 3 | |
| 해부 | scalp
|
두피 | dict | 3 | |
| 해부 | scalp
|
두피 | dict | 3 | |
| 질환 | alopecia areata
|
원형 탈모증 | dict | 2 | |
| 질환 | alopecia areata
|
원형 탈모증 | dict | 2 | |
| 질환 | alopecia areata
|
원형 탈모증 | dict | 2 |
🏷️ 키워드 / MeSH 📖 같은 키워드 OA만
인용 관계
그래프 OA 노드: 8/8 (100%)
· 참조 0편 · 후속 8편
이 논문을 인용한 후속 연구 20
- Epidemiology and burden of alopecia areata: a systematic review.
- "'You lose your hair, what's the big deal?' I was so embarrassed, I was so self-conscious, I was so …
- The Role of Micronutrients in Alopecia Areata: A Review.
- Alopecia areata: Animal models illuminate autoimmune pathogenesis and novel immunotherapeutic strate…
- Complementary and Alternative Treatments for Alopecia: A Comprehensive Review.
- Alopecia Areata Treatment Patterns, Healthcare Resource Utilization, and Comorbidities in the US Pop…
- Drug discovery for alopecia: gone today, hair tomorrow.
- The Invisible Impact of a Visible Disease: Psychosocial Impact of Alopecia Areata.
- Utilization of Mental Health Resources and Complementary and Alternative Therapies for Alopecia Area…
- Prevalence and Risk Factors Associated with the Occurrence of Autoimmune Diseases in Patients with A…
- Understanding autoimmunity of vitiligo and alopecia areata.
- Integrated Safety Analysis of Ritlecitinib, an Oral JAK3/TEC Family Kinase Inhibitor, for the Treatm…
- Development of the Scalp Hair Assessment PRO™ measure for alopecia areata.
- Serum Vitamin D in patients with alopecia areata.
- Integrated single-cell chromatin and transcriptomic analyses of human scalp identify gene-regulatory…
- Cumulative Life Course Impairment of Alopecia Areata.
- Whole exome sequencing in Alopecia Areata identifies rare variants in KRT82.
- Treatments for alopecia areata: a network meta-analysis.
- Patient characteristics and disease burden of alopecia areata in the Danish Skin Cohort.
- Altered expression of intracellular Toll-like receptors in peripheral blood mononuclear cells from p…
같은 제1저자의 인용 많은 논문 (5)
- Adipose and Hair Function: An aPPARent Connection.
- Single nucleotide polymorphisms affecting galantamine binding to acetylcholinesterase in Alzheimer's disease: a structural bioinformatics study.
- Development of a Dynamic Counterfactual Risk Stratification Strategy for Newly Diagnosed Patients With AML Treated With Venetoclax and Azacitidine.
- Investigating molecular background of multiple sclerosis through multi-omics: linking via psychoneuroimmunology.
- Geochemistry and mineralogy of coal mine overburden (waste): A study towards their environmental implications.
🏷️ 같은 키워드 · 무료전문 — 이 논문 MeSH/keyword 기반
📖 비슷한 OA 논문 — 같은 카테고리, 무료 전문 가능
-
Alopecia areata.
TL;DRAlopecia areata is difficult to manage medically, but recent advances in understanding the molecular mechanisms have revealed new treatments and the possibility of remission in the…
-
Epidemiology and burden of alopecia areata: a systematic review.
TL;DRAA is the most prevalent autoimmune disorder and the second most prevalent hair loss disorder after androgenetic alopecia, and the lifetime risk in the global population is approxi…
-
Two Phase 3 Trials of Baricitinib for Alopecia Areata.
TL;DRIn two phase 3 trials involving patients with severe alopecia areata, oral baricitinib was superior to placebo with respect to hair regrowth at 36 weeks.
-
Treatment options for androgenetic alopecia: Efficacy, side effects, compliance, financial considerations, and ethics.
TL;DRAlthough a variety of medical, surgical, light‐based and nutraceutical treatment options are available to slow or reverse the progression of AGA, it can be challenging to select ap…
-
Hair follicle immune privilege and its collapse in alopecia areata.
TL;DRA key goal for effective AA management is the re‐establishment of a functional HF IP, which will also provide superior protection from disease relapse, and may confer increased sus…