Hair follicle immune privilege and its collapse in alopecia areata.
5/5 보강
TL;DR
A key goal for effective AA management is the re‐establishment of a functional HF IP, which will also provide superior protection from disease relapse, and may confer increased susceptibility to AA for some individuals.
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· 인용됨 103
📑 인용한 논문 (6) ▾
- Collapse and Restoration of Hair Follicle Immune Privilege Ex Vivo: A Model for Alopecia A… Methods in molecular biology (Clifton, N.J.) · 2026
- Insights into the Diagnostics and Therapeutics of Alopecia Areata-An Indian Context. Indian dermatology online journal · 2026
- Illness Perception, Emotional Distress, and Obsessive-Compulsive Symptomatology in Patient… Behavioral sciences (Basel, Switzerland) · 2026
- Squaric Acid Dibutylester Promotes Innate Immune-Driven Hair Growth with CD206 Macrophage … JID innovations : skin science from molecules to population health · 2026
- Stem cell-based therapies for alopecia areata: a narrative review. Stem cell research & therapy · 2026
- Multi-omics and AI-driven advances in miRNA-mediated hair follicle regulation in cashmere … Frontiers in veterinary science · 2025
연도별 인용 (2020–2026) · 합계 292
OpenAlex 토픽 ·
Hair Growth and Disorders
Dermatology and Skin Diseases
Immune Cell Function and Interaction
🇰🇷 한글 요약 🌐 Abstract
【연구 목적】
모낭(hair follicle)의 면역특권(immune privilege, IP) 기전과 원형 탈모증(alopecia areata, AA)에서 이 면역특권이 붕괴되는 과정을 정리하고, 이를 회복시키는 치료 전략의 근거를 제시한다.
【방법】
사람 모낭의 능동적·수동적 면역특권 기전(MHC class I/II 발현 저하, CD200 등 "no danger" 신호, 면역억제성 분비 환경)에 대한 기존 문헌과 동물 모델 실험 결과를 종합적으로 고찰하였다.
【주요 결과】
성장기(anagen) 모구(hair bulb)의 면역특권 붕괴는 AA 발생의 필수 전제 조건으로, 병변 모낭에 NKG2D+ T세포와 NK세포(natural killer cell)가 침윤하고 모낭주위 비만세포(perifollicular mast cell)가 염증성 표현형으로 전환되며 자가반응성 CD8+ T세포와 상호작용한다. 동물 모델에서 IFN-γ를 분비하는 CD8+ T세포·NK세포만으로도 AA 표현형 유도가 가능하며, CD4+ T세포는 악화 인자, 조절 T세포(Treg)·iNKT 세포는 보호 인자로 작용한다.
【임상적 시사점 (성형외과 의사 관점)】
모발이식(hair transplantation)이나 탈모 치료 환자 중 AA 병력이 있거나 선천적 면역특권 결핍이 의심되는 경우 재발 위험이 높으므로 시술 전 면역학적 평가와 환자 상담이 필요하다. AA 환자의 근본적 관리는 단순 면역억제가 아니라 모낭 IP의 재확립을 목표로 해야 하며, CD200·면역억제 사이토카인 경로를 활용한 국소 치료제(JAK 억제제 등)와의 병용 전략이 재발 방지에 유리할 수 있다. 모발이식 시 모낭주위 비만세포 활성화를 자극할 수 있는 외부 인자(과도한 기계적 손상, 감염) 최소화가 IP 유지에 중요하다.
Anagen stage hair follicles (HFs) exhibit "immune privilege (IP)" from the level of the bulge downwards to the bulb. Both passive and active IP mechanisms protect HFs from physiologically undesired immune responses and limit immune surveillance. IP is relative, not absolute, and is primarily based on absent, or greatly reduced, intra-follicular antigen presentation via MHC class I and II molecules, along with prominent expression of "no danger" signals like CD200 and the creation of an immunoinhibitory signalling milieu generated by the secretory activities of HFs. Perifollicular mast cells, Tregs and other immunocytes may also contribute to HF IP maintenance in healthy human skin. Collapse of anagen hair bulb IP is an essential prerequisite for the development of alopecia areata (AA). In AA, lesional HFs are rapidly infiltrated by NKG2D + T cells and natural killer (NK) cells, while perifollicular mast cells acquire a profoundly pro-inflammatory phenotype and interact with autoreactive CD8+ T cells. Using animal models, significant functional evidence has accumulated that demonstrates the dominance of the immune system in AA pathogenesis. Purified CD8+T-cell and NK cell populations alone, which secrete fγ, suffice to induce the AA phenotype, while CD4+T-cells aggravate it, and Tregs and iNKT cells may provide relative protection against AA development. While IP collapse may be induced by exogenous agents, inherent IP deficiencies might confer increased susceptibility to AA for some individuals. Thus, a key goal for effective AA management is the re-establishment of a functional HF IP, which will also provide superior protection from disease relapse.
【연구 목적】 모낭(hair follicle)의 면역특권(immune privilege, IP) 기전과 원형 탈모증(alopecia areata, AA)에서 이 면역특권이 붕괴되는 과정을 정리하고, 이를 회복시키는 치료 전략의 근거를 제시한다.
APA 7
Bertolini, M., McElwee, K., Gilhar, A., Bulfone-Paus, S., & Paus, R. (2020). Hair follicle immune privilege and its collapse in alopecia areata.. Experimental dermatology, 29(8), 703-725. https://doi.org/10.1111/exd.14155
Vancouver
Bertolini M, McElwee K, Gilhar A, Bulfone-Paus S, Paus R. Hair follicle immune privilege and its collapse in alopecia areata. Experimental dermatology. 2020;29(8):703-725. doi:10.1111/exd.14155
AMA 11
Bertolini M, McElwee K, Gilhar A, Bulfone-Paus S, Paus R. Hair follicle immune privilege and its collapse in alopecia areata. Experimental dermatology. 2020;29(8):703-725. doi:10.1111/exd.14155
Chicago
Bertolini, M., McElwee, K., Gilhar, A., Bulfone-Paus, S., and Paus, R.. 2020. "Hair follicle immune privilege and its collapse in alopecia areata." Experimental dermatology 29 (8): 703-725. https://doi.org/10.1111/exd.14155
MLA 9
Bertolini, M., et al. "Hair follicle immune privilege and its collapse in alopecia areata." Experimental dermatology, vol. 29, no. 8, 2020, pp. 703-725. doi:10.1111/exd.14155.
PMID
32682334 ↗
추출된 의학 개체 (NER)
전체 NER 표 보기
| 유형 | 영어 표현 | 한국어 / 풀이 | UMLS CUI | 출처 | 등장 |
|---|---|---|---|---|---|
| 질환 | alopecia areata
|
원형 탈모증 | dict | 2 | |
| 해부 | hair follicle
|
모낭 | dict | 1 |
🏷️ 키워드 / MeSH 📖 같은 키워드 OA만
- Alopecia Areata
- Animals
- B7-H1 Antigen
- Cytokines
- Hair Follicle
- Histocompatibility Antigens Class I
- Histocompatibility Antigens Class II
- Humans
- Immune Privilege
- Mast Cells
- Neuropeptides
- Signal Transduction
- T-Lymphocytes
- Regulatory
- IFNγ
- NK cell
- NKG2D
- alopecia areata
- immune privilege
- immune privilege collapse
- mast cell
인용 관계
그래프 OA 노드: 5/8 (63%)
· 참조 0편 · 후속 5편
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