Epidemiology of alopecia areata, ophiasis, totalis, and universalis: A systematic review and meta-analysis.
💡 한 문장 핵심
원형탈모증, ophiasis, 전두탈모증 및 전신탈모증의 역학: 체계적 문헌고찰 및 메타분석.
메타분석
5/5 보강
TL;DR
A systematic review of all published cohort and cross-sectional studies that analyzed AA and its subtypes found that AA prevalence is lower in adults than children, is increasing over time, and significantly differs by region.
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· 인용됨 135
📑 인용한 논문 (6) ▾
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- Long-Term Efficacy and Safety of Ritlecitinib in Adults and Adolescents with Alopecia Area… American journal of clinical dermatology · 2026
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연도별 인용 (2020–2026) · 합계 317
OpenAlex 토픽 ·
Hair Growth and Disorders
Autoimmune Bullous Skin Diseases
Dermatology and Skin Diseases
🇰🇷 한글 요약 🌐 Abstract
【연구 목적】
원형 탈모증(alopecia areata, AA)과 그 아형인 전두 탈모(alopecia totalis), 사행성 탈모(ophiasis), 전신 탈모(alopecia universalis)의 유병률·발생률 및 예측 인자를 규명하기 위한 체계적 문헌고찰 및 메타분석입니다.
【방법】
MEDLINE, Embase, Scopus, Cochrane 등 6개 데이터베이스에서 코호트 및 단면 연구를 검색하여 94편을 선정했고, 이질성이 매우 커(I²=99.97%) 무작위효과 모형으로 통합 분석했습니다. 최소 2명의 검토자가 선별 및 데이터 추출을 수행했습니다.
【주요 결과】
AA의 통합 유병률은 2.11%였으며, 인구기반 연구(0.75%)보다 병원기반 연구(3.47%)에서 높았습니다. 아형은 전두 탈모 0.08%, 사행성 탈모 0.02%, 전신 탈모 0.03%로 드물었습니다. 유병률은 2000년 이전 1.02%에서 2009년 이후 3.22%로 시간 경과에 따라 증가했고, 지역별 차이가 있었으며, 성인(1.47%)보다 소아(1.92%)에서 더 높았습니다.
【임상적 시사점 (성형외과 의사 관점)】
AA는 전 세계 인구의 약 2%가 겪는 흔한 자가면역 질환으로, 모발이식·두피 시술 상담 시 흔히 마주칠 수 있어 비반흔성(non-scarring) 탈모와의 감별이 중요합니다. 활동성 AA는 자가면역 특성상 모발이식 결과가 불안정하므로, 질환이 안정화된 이후 시술을 고려하고 우선 내과적(피부과) 치료로 의뢰하는 것이 바람직합니다.
[BACKGROUND] Alopecia areata (AA) is a common autoimmune alopecia with heterogeneous severity and distribution. Previous studies found conflicting results about AA epidemiology.
[OBJECTIVE] To determine the prevalence, incidence, and predictors of AA, alopecia totalis, alopecia ophiasis, and alopecia universalis.
[METHODS] A systematic review of all published cohort and cross-sectional studies that analyzed AA and its subtypes. MEDLINE, Embase, LILACS, Scopus, Cochrane Library, and GREAT were searched. At least 2 reviewers performed study title/abstract review and data extraction. Random-effects meta-analysis was used because of significant heterogeneity (I = 99.97%).
[RESULTS] Ninety-four studies met the inclusion criteria. The pooled prevalence (95% confidence interval, N) of AA overall was 2.11% (1.82-2.42, N = 302,157,365), with differences of population-based (0.75% [0.49-1.06%], N = 301,173,403) and clinic-based (3.47% [3.01-3.96], N = 983,962) studies. The prevalences of alopecia totalis, ophiasis, and universalis were 0.08% (0.04-0.13, N = 1,088,149), 0.02% (0.00-0.06, N = 1,075,203), and 0.03% (0.01-0.06, N = 1,085,444), respectively. AA prevalence (95% confidence interval) increased over time (<2000: 1.02% [0.85-1.22]; 2000-2009: 1.76% [1.51-2.03]; >2009: 3.22% [2.59-3.92]; P < .0001) and differed by region. AA prevalence was significantly lower in adults (1.47% [1.18-1.80]) than children (1.92% [1.31-2.65]; P < .0001).
[CONCLUSIONS] AA affects 2% of the global population. AA prevalence is lower in adults than children, is increasing over time, and significantly differs by region.
[OBJECTIVE] To determine the prevalence, incidence, and predictors of AA, alopecia totalis, alopecia ophiasis, and alopecia universalis.
[METHODS] A systematic review of all published cohort and cross-sectional studies that analyzed AA and its subtypes. MEDLINE, Embase, LILACS, Scopus, Cochrane Library, and GREAT were searched. At least 2 reviewers performed study title/abstract review and data extraction. Random-effects meta-analysis was used because of significant heterogeneity (I = 99.97%).
[RESULTS] Ninety-four studies met the inclusion criteria. The pooled prevalence (95% confidence interval, N) of AA overall was 2.11% (1.82-2.42, N = 302,157,365), with differences of population-based (0.75% [0.49-1.06%], N = 301,173,403) and clinic-based (3.47% [3.01-3.96], N = 983,962) studies. The prevalences of alopecia totalis, ophiasis, and universalis were 0.08% (0.04-0.13, N = 1,088,149), 0.02% (0.00-0.06, N = 1,075,203), and 0.03% (0.01-0.06, N = 1,085,444), respectively. AA prevalence (95% confidence interval) increased over time (<2000: 1.02% [0.85-1.22]; 2000-2009: 1.76% [1.51-2.03]; >2009: 3.22% [2.59-3.92]; P < .0001) and differed by region. AA prevalence was significantly lower in adults (1.47% [1.18-1.80]) than children (1.92% [1.31-2.65]; P < .0001).
[CONCLUSIONS] AA affects 2% of the global population. AA prevalence is lower in adults than children, is increasing over time, and significantly differs by region.
- 표본수 (n) 302,157,365
- p-value P < .0001
- 연구 설계 systematic review
【연구 목적】 원형 탈모증(alopecia areata, AA)과 그 아형인 전두 탈모(alopecia totalis), 사행성 탈모(ophiasis), 전신 탈모(alopecia universalis)의 유병률·발생률 및 예측 인자를 규명하기 위한 체계적 문헌고찰 및 메타분석입니다.
APA 7
Lee, H. H., Gwillim, E., Patel, K. R., Hua, T., Rastogi, S., Ibler, E., & Silverberg, J. I. (2020). Epidemiology of alopecia areata, ophiasis, totalis, and universalis: A systematic review and meta-analysis.. Journal of the American Academy of Dermatology, 82(3), 675-682. https://doi.org/10.1016/j.jaad.2019.08.032
Vancouver
Lee HH, Gwillim E, Patel KR, Hua T, Rastogi S, Ibler E, et al. Epidemiology of alopecia areata, ophiasis, totalis, and universalis: A systematic review and meta-analysis. Jour. Amer. Acad. Derm.. 2020;82(3):675-682. doi:10.1016/j.jaad.2019.08.032
AMA 11
Lee HH, Gwillim E, Patel KR, Hua T, Rastogi S, Ibler E, et al. Epidemiology of alopecia areata, ophiasis, totalis, and universalis: A systematic review and meta-analysis. Jour. Amer. Acad. Derm.. 2020;82(3):675-682. doi:10.1016/j.jaad.2019.08.032
Chicago
Lee, H. H., Gwillim, E., Patel, K. R., Hua, T., Rastogi, S., Ibler, E., and Silverberg, J. I.. 2020. "Epidemiology of alopecia areata, ophiasis, totalis, and universalis: A systematic review and meta-analysis." Journal of the American Academy of Dermatology 82 (3): 675-682. https://doi.org/10.1016/j.jaad.2019.08.032
MLA 9
Lee, H. H., et al. "Epidemiology of alopecia areata, ophiasis, totalis, and universalis: A systematic review and meta-analysis." Journal of the American Academy of Dermatology, vol. 82, no. 3, 2020, pp. 675-682. doi:10.1016/j.jaad.2019.08.032.
PMID
31437543 ↗
추출된 의학 개체 (NER)
전체 NER 표 보기
| 유형 | 영어 표현 | 한국어 / 풀이 | UMLS CUI | 출처 | 등장 |
|---|---|---|---|---|---|
| 질환 | alopecia areata
|
원형 탈모증 | dict | 2 |
🏷️ 키워드 / MeSH 📖 같은 키워드 OA만
인용 관계
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