Alopecia areata: Disease characteristics, clinical evaluation, and new perspectives on pathogenesis.
💡 한 문장 핵심
원형 탈모: 질환 특성, 임상적 평가, 그리고 발병 기전에 관한 새로운 관점.
5/5 보강
TL;DR
Patients with AA frequently experience marked impairment in psychological well-being, self-esteem, and may be more likely to suffer from psychiatric comorbidities.
PICO 자동 추출 (휴리스틱, conf 2/4)
유사 논문P · Population 대상 환자/모집단
환자: AA frequently experience marked impairment in psychological well-being, self-esteem, and may be more likely to suffer from psychiatric comorbidities
I · Intervention 중재 / 시술
추출되지 않음
C · Comparison 대조 / 비교
추출되지 않음
O · Outcome 결과 / 결론
Patients with AA frequently experience marked impairment in psychological well-being, self-esteem, and may be more likely to suffer from psychiatric comorbidities. Part one of this two-part continuing medical education series describes the epidemiology, clinical evaluation, prognosis, and recent advancements in the understanding of the pathogenesis of AA.
📑 코퍼스 인용 관계
· 인용됨 190
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연도별 인용 (2018–2026) · 합계 514
OpenAlex 토픽 ·
Hair Growth and Disorders
RNA regulation and disease
Genetic and rare skin diseases.
🇰🇷 한글 요약 🌐 Abstract
【연구 목적】
원형 탈모증(alopecia areata, AA)의 역학, 임상 평가, 예후, 그리고 최근 밝혀진 병인 기전을 정리하여 임상의에게 최신 지견을 제공하는 것을 목적으로 한 2부작 평생의학교육(CME) 시리즈의 1부이다.
【방법】
원형 탈모증의 임상 양상, 자가면역 기전, 심리사회적 영향에 대한 기존 문헌을 종합적으로 검토한 서술적 종설(narrative review) 형식의 연구이다.
【주요 결과】
원형 탈모증은 작은 국소 패치형부터 전신 모발 소실(alopecia universalis)까지 다양한 임상 스펙트럼을 보이며, 모든 연령·성별·인종에서 발생한다. 발병 기전은 모낭(hair follicle)의 면역특권(immune privilege) 소실, 자가면역에 의한 모낭 파괴, 염증 경로 상향조절이 핵심으로 지목되며, 환자들은 자존감 저하·불안·우울 등 정신건강 동반질환 위험이 유의하게 높다.
【임상적 시사점 (성형외과 의사 관점)】
모발이식 상담 시 두피(scalp)의 패치형 탈모가 반흔성(scarring)인지 비반흔성(원형 탈모)인지 반드시 감별해야 하며, 활동성 원형 탈모는 코브너 현상(Koebner phenomenon) 위험과 예측 불가능한 재발 때문에 이식의 절대적 비적응증이다. 또한 환자의 심리적 고통이 크므로 JAK 억제제 등 최신 내과적 치료로 의뢰하거나 두피 문신(SMP, scalp micropigmentation)·가발 등 비수술적 대안을 함께 제시하는 통합적 접근이 필요하다.
Alopecia areata (AA) is a common, inflammatory, nonscarring type of hair loss. Significant variations in the clinical presentation of AA have been observed, ranging from small, well-circumscribed patches of hair loss to a complete absence of body and scalp hair. Patients affected by AA encompass all age groups, sexes, and ethnicities, and may experience frustration with the unpredictable nature of their disease for which there is currently no definitive treatment. The cause of AA remains incompletely understood, though it is believed to result-at least in part-from a loss of immune privilege in the hair follicle, autoimmune-mediated hair follicle destruction, and the upregulation of inflammatory pathways. Patients with AA frequently experience marked impairment in psychological well-being, self-esteem, and may be more likely to suffer from psychiatric comorbidities. Part one of this two-part continuing medical education series describes the epidemiology, clinical evaluation, prognosis, and recent advancements in the understanding of the pathogenesis of AA.
【연구 목적】 원형 탈모증(alopecia areata, AA)의 역학, 임상 평가, 예후, 그리고 최근 밝혀진 병인 기전을 정리하여 임상의에게 최신 지견을 제공하는 것을 목적으로 한 2부작 평생의학교육(CME) 시리즈의 1부이다.
APA 7
Strazzulla, L. C., Wang, E. H. C., Avila, L., K, L. S., Brinster, N., Christiano, A. M., & Shapiro, J. (2018). Alopecia areata: Disease characteristics, clinical evaluation, and new perspectives on pathogenesis.. Journal of the American Academy of Dermatology, 78(1), 1-12. https://doi.org/10.1016/j.jaad.2017.04.1141
Vancouver
Strazzulla LC, Wang EHC, Avila L, K LS, Brinster N, Christiano AM, et al. Alopecia areata: Disease characteristics, clinical evaluation, and new perspectives on pathogenesis. Jour. Amer. Acad. Derm.. 2018;78(1):1-12. doi:10.1016/j.jaad.2017.04.1141
AMA 11
Strazzulla LC, Wang EHC, Avila L, K LS, Brinster N, Christiano AM, et al. Alopecia areata: Disease characteristics, clinical evaluation, and new perspectives on pathogenesis. Jour. Amer. Acad. Derm.. 2018;78(1):1-12. doi:10.1016/j.jaad.2017.04.1141
Chicago
Strazzulla, L. C., Wang, E. H. C., Avila, L., K, L. S., Brinster, N., Christiano, A. M., and Shapiro, J.. 2018. "Alopecia areata: Disease characteristics, clinical evaluation, and new perspectives on pathogenesis." Journal of the American Academy of Dermatology 78 (1): 1-12. https://doi.org/10.1016/j.jaad.2017.04.1141
MLA 9
Strazzulla, L. C., et al. "Alopecia areata: Disease characteristics, clinical evaluation, and new perspectives on pathogenesis." Journal of the American Academy of Dermatology, vol. 78, no. 1, 2018, pp. 1-12. doi:10.1016/j.jaad.2017.04.1141.
PMID
29241771 ↗
추출된 의학 개체 (NER)
전체 NER 표 보기
| 유형 | 영어 표현 | 한국어 / 풀이 | UMLS CUI | 출처 | 등장 |
|---|---|---|---|---|---|
| 해부 | hair follicle
|
모낭 | dict | 2 | |
| 해부 | hair follicle
|
모낭 | dict | 2 | |
| 해부 | hair follicle
|
모낭 | dict | 2 | |
| 질환 | alopecia areata
|
원형 탈모증 | dict | 2 | |
| 질환 | alopecia areata
|
원형 탈모증 | dict | 2 | |
| 질환 | alopecia areata
|
원형 탈모증 | dict | 2 | |
| 해부 | scalp
|
두피 | dict | 1 | |
| 해부 | scalp
|
두피 | dict | 1 | |
| 해부 | scalp
|
두피 | dict | 1 |
🏷️ 키워드 / MeSH 📖 같은 키워드 OA만
- Adult
- Age Factors
- Age of Onset
- Alopecia Areata
- CD4-Positive T-Lymphocytes
- Education
- Medical
- Continuing
- Female
- Genetic Predisposition to Disease
- Hair Follicle
- Humans
- Incidence
- Male
- Prognosis
- Quality of Life
- Severity of Illness Index
- Sex Factors
- alopecia areata
- alopecia totalis
- alopecia universalis
- pathogenesis
- prognosis
- subtype
🤖 이 논문을 인용한 AI 인사이트 · 2건
📰 주간
🏷 면역·염증
원형 탈모 — 자가면역, JAK 억제제 부상
P: 원형 탈모증(alopecia areata) 환자. 다만 상위 인용 문헌이 종설·체계적 문헌고찰·질환 개요 중심이라 특정 코호트보다 질환 일반 집 O: 발병 기전·역학 종합 근거이며, 표적 치료의 장기 유효성·재발률이 향후 평가 결과지표로 제시됩니다. 표준화된 유병률·자연경과 데이터는 미충족 과
📰 주간
🏷 면역·염증
모낭 — 자가면역·재생 다축 연구
P: 원형탈모(AA) 및 반흔성 탈모 환자, PCOS 환자, 그리고 telogen 단계 표피 모낭 동물·세포 모델(WIHN 모델, 단일세포 전사체 분 O: 표피·모낭 세포군 식별(25개 cluster) 및 공간적 시그니처 정량화, 면역세포-모낭 줄기세포 상호작용, 임상 표현형 및 진단 기준 다양성,
이 논문은 위 AI 빅데이터 분석에 인용된 근거 논문입니다.
인용 관계
그래프 OA 노드: 6/8 (75%)
· 참조 0편 · 후속 6편
이 논문을 인용한 후속 연구 20
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- Functional complexity of hair follicle stem cell niche and therapeutic targeting of niche dysfunctio…
- Pathomechanisms of immune-mediated alopecia.
- Frequency of the Types of Alopecia at Twenty-Two Specialist Hair Clinics: A Multicenter Study.
- Hair Regrowth Outcomes of Contact Immunotherapy for Patients With Alopecia Areata: A Systematic Revi…
- Alopecia Areata: Current Treatments and New Directions.
- The efficacy and safety of JAK inhibitors for alopecia areata: A systematic review and meta-analysis…
- Comorbid Conditions Associated with Alopecia Areata: A Systematic Review and Meta-analysis.
- Defining Severity in Alopecia Areata: Current Perspectives and a Multidimensional Framework.
- JAK Inhibitors for Treatment of Alopecia Areata.
- Epidemiological Trends in Alopecia Areata at the Global, Regional, and National Levels.
- Novel potential therapeutic targets of alopecia areata.
- Janus Kinase Inhibitors for Alopecia Areata: A Systematic Review and Meta-Analysis.
- Prevalence and Risk Factors Associated with the Occurrence of Autoimmune Diseases in Patients with A…
- Deciphering the Complex Immunopathogenesis of Alopecia Areata.
- Efficacy and safety of different JAK inhibitors in the treatment of alopecia areata: a network meta-…
- Alopecia Areata: A Review of the Role of Oxidative Stress, Possible Biomarkers, and Potential Novel …
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Alopecia areata.
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