Alopecia areata: An appraisal of new treatment approaches and overview of current therapies.
💡 한 문장 핵심
원형탈모: 새로운 치료 접근법 평가와 현행 치료법 개관.
5/5 보강
TL;DR
The evidence supporting new treatment methods, among them Janus kinase inhibitors, are described and an overview of conventional therapy is provided with new insights gleaned from recent studies.
📑 코퍼스 인용 관계
· 인용됨 90
📑 인용한 논문 (6) ▾
- Network pharmacology, molecular docking, and dynamics reveal the mechanisms of Hejie Sheng… Medicine · 2026
- Stem cell-based therapies for alopecia areata: a narrative review. Stem cell research & therapy · 2026
- Performance exploration of multi-gene panels of alopecia areata susceptibility and drug-bi… Frontiers in physiology · 2025
- Multi-omics analyses, cell experiments, and network pharmacology tools identified key prot… Clinical proteomics · 2025
- Knowledge, attitudes, and practices toward disease management among alopecia areata patien… BMC public health · 2025
- Ophthalmologic Comorbidities in Alopecia Areata. Journal of clinical medicine · 2025
연도별 인용 (2018–2026) · 합계 247
OpenAlex 토픽 ·
Hair Growth and Disorders
Autoimmune Bullous Skin Diseases
Dupuytren's Contracture and Treatments
🇰🇷 한글 요약 🌐 Abstract
【연구 목적】
원형 탈모증(alopecia areata)에 대한 새로운 치료법, 특히 야누스 키나아제 억제제(JAK inhibitors)의 근거를 평가하고 기존 치료법을 종합적으로 정리하는 것을 목적으로 한다.
【방법】
지속적 의학교육(CME) 시리즈의 두 번째 논문으로, 신규 치료법의 유효성·부작용·지속성에 관한 근거를 문헌 고찰 방식으로 검토하였다. 환자를 소아/성인, 경증/중증으로 층화하여 치료 결정 알고리즘을 제시하였다.
【주요 결과】
현재까지 관해를 유도하고 유지하는 치료법은 없으며, 국소·전신·주사 요법은 임상 결과가 일정하지 않다. JAK 억제제는 유망한 효과를 보이나 부작용과 치료 중단 시 재발(durability) 문제가 남아 있으며, 기존 치료법(국소 스테로이드, 병변 내 주사, 면역요법 등)도 재평가가 필요하다.
【임상적 시사점 (성형외과 의사 관점)】
모발이식(hair transplantation) 상담 시 원형 탈모증 환자는 자가면역 활동성으로 인해 이식 모낭도 탈락할 수 있어 원칙적으로 비적응증임을 인지해야 한다. JAK 억제제 등 약물 치료로 안정화된 후에야 미용적 접근(두피 문신 SMP, 가발, 선택적 이식)을 고려할 수 있으며, 활동기 환자는 피부과 협진을 우선 권고해야 한다.
Many therapies are available for the treatment of alopecia areata, including topical, systemic, and injectable modalities. However, these treatment methods produce variable clinical outcomes and there are no currently available treatments that induce and sustain remission. When making management decisions, clinicians must first stratify patients into pediatric versus adult populations. Disease severity should then be determined (limited vs extensive) before deciding the final course of therapy. The second article in this continuing medical education series describes the evidence supporting new treatment methods, among them Janus kinase inhibitors. We evaluate the evidence concerning the efficacy, side effects, and durability of these medications. An overview of conventional therapy is also provided with new insights gleaned from recent studies. Finally, future promising therapeutic options that have not yet been fully evaluated will also be presented.
【연구 목적】 원형 탈모증(alopecia areata)에 대한 새로운 치료법, 특히 야누스 키나아제 억제제(JAK inhibitors)의 근거를 평가하고 기존 치료법을 종합적으로 정리하는 것을 목적으로 한다.
APA 7
Strazzulla, L. C., Wang, E. H. C., Avila, L., K, L. S., Brinster, N., Christiano, A. M., & Shapiro, J. (2018). Alopecia areata: An appraisal of new treatment approaches and overview of current therapies.. Journal of the American Academy of Dermatology, 78(1), 15-24. https://doi.org/10.1016/j.jaad.2017.04.1142
Vancouver
Strazzulla LC, Wang EHC, Avila L, K LS, Brinster N, Christiano AM, et al. Alopecia areata: An appraisal of new treatment approaches and overview of current therapies. Jour. Amer. Acad. Derm.. 2018;78(1):15-24. doi:10.1016/j.jaad.2017.04.1142
AMA 11
Strazzulla LC, Wang EHC, Avila L, K LS, Brinster N, Christiano AM, et al. Alopecia areata: An appraisal of new treatment approaches and overview of current therapies. Jour. Amer. Acad. Derm.. 2018;78(1):15-24. doi:10.1016/j.jaad.2017.04.1142
Chicago
Strazzulla, L. C., Wang, E. H. C., Avila, L., K, L. S., Brinster, N., Christiano, A. M., and Shapiro, J.. 2018. "Alopecia areata: An appraisal of new treatment approaches and overview of current therapies." Journal of the American Academy of Dermatology 78 (1): 15-24. https://doi.org/10.1016/j.jaad.2017.04.1142
MLA 9
Strazzulla, L. C., et al. "Alopecia areata: An appraisal of new treatment approaches and overview of current therapies." Journal of the American Academy of Dermatology, vol. 78, no. 1, 2018, pp. 15-24. doi:10.1016/j.jaad.2017.04.1142.
PMID
29241773 ↗
추출된 의학 개체 (NER)
전체 NER 표 보기
| 유형 | 영어 표현 | 한국어 / 풀이 | UMLS CUI | 출처 | 등장 |
|---|---|---|---|---|---|
| 질환 | alopecia areata
|
원형 탈모증 | dict | 2 | |
| 질환 | alopecia areata
|
원형 탈모증 | dict | 2 | |
| 질환 | alopecia areata
|
원형 탈모증 | dict | 2 |
🏷️ 키워드 / MeSH 📖 같은 키워드 OA만
- Administration
- Oral
- Topical
- Adrenal Cortex Hormones
- Alopecia Areata
- Dermatologic Agents
- Education
- Medical
- Continuing
- Female
- Humans
- Immunotherapy
- Injections
- Intralesional
- Male
- Methotrexate
- Minoxidil
- Quality of Life
- Risk Assessment
- Severity of Illness Index
- Treatment Outcome
- JAK inhibitors
- alopecia areata
- alopecia totalis
… 외 4개
인용 관계
그래프 OA 노드: 7/8 (88%)
· 참조 0편 · 후속 7편
이 논문을 인용한 후속 연구 20
- Alopecia Areata: an Update on Etiopathogenesis, Diagnosis, and Management.
- Minoxidil and its use in hair disorders: a review.
- Functional complexity of hair follicle stem cell niche and therapeutic targeting of niche dysfunctio…
- Hair Regrowth Outcomes of Contact Immunotherapy for Patients With Alopecia Areata: A Systematic Revi…
- JAK Inhibitors for Treatment of Alopecia Areata.
- Alopecia Areata Treatment Patterns, Healthcare Resource Utilization, and Comorbidities in the US Pop…
- Baricitinib for the Treatment of Alopecia Areata.
- Novel potential therapeutic targets of alopecia areata.
- Alopecia Areata: Burden of Disease, Approach to Treatment, and Current Unmet Needs.
- The current state of knowledge of the immune ecosystem in alopecia areata.
- Monotherapy for Alopecia Areata: A Systematic Review and Network Meta-Analysis.
- A phase 2a randomized vehicle-controlled multi-center study of the safety and efficacy of delgocitin…
- Prevalence, comorbidities, and treatment patterns of Japanese patients with alopecia areata: A descr…
- Application of Topical Immunotherapy in the Treatment of Alopecia Areata: A Review and Update.
- Treatments for alopecia areata: a network meta-analysis.
- Hair Follicle Melanocytes Initiate Autoimmunity in Alopecia Areata: a Trigger Point.
- Oral Tofacitinib and Systemic Corticosteroids, Alone or in Combination, in Patients With Moderate-to…
- Alopecia Areata: Pathogenesis, Diagnosis, and Therapies.
- Clinical and Genetic Aspects of Alopecia Areata: A Cutting Edge Review.
- Comparative Efficacy and Safety of Janus Kinase Inhibitors Used in Alopecia Areata: A Systematic Rev…
같은 제1저자의 인용 많은 논문 (5)
- Alopecia areata: Disease characteristics, clinical evaluation, and new perspectives on pathogenesis.
- Prognosis, treatment, and disease outcomes in frontal fibrosing alopecia: A retrospective review of 92 cases.
- An Overview of the Biology of Platelet-Rich Plasma and Microneedling as Potential Treatments for Alopecia Areata.
- Image Gallery: Treatment of refractory alopecia universalis with oral tofacitinib citrate and adjunct intralesional triamcinolone injections.
- Novel Treatment Using Low-Dose Naltrexone for Lichen Planopilaris.
🏷️ 같은 키워드 · 무료전문 — 이 논문 MeSH/keyword 기반
📖 비슷한 OA 논문 — 같은 카테고리, 무료 전문 가능
-
Alopecia areata.
TL;DRAlopecia areata is difficult to manage medically, but recent advances in understanding the molecular mechanisms have revealed new treatments and the possibility of remission in the…
-
Epidemiology and burden of alopecia areata: a systematic review.
TL;DRAA is the most prevalent autoimmune disorder and the second most prevalent hair loss disorder after androgenetic alopecia, and the lifetime risk in the global population is approxi…
-
Two Phase 3 Trials of Baricitinib for Alopecia Areata.
TL;DRIn two phase 3 trials involving patients with severe alopecia areata, oral baricitinib was superior to placebo with respect to hair regrowth at 36 weeks.
-
Treatment options for androgenetic alopecia: Efficacy, side effects, compliance, financial considerations, and ethics.
TL;DRAlthough a variety of medical, surgical, light‐based and nutraceutical treatment options are available to slow or reverse the progression of AGA, it can be challenging to select ap…
-
Hair follicle immune privilege and its collapse in alopecia areata.
TL;DRA key goal for effective AA management is the re‐establishment of a functional HF IP, which will also provide superior protection from disease relapse, and may confer increased sus…