Male androgenetic alopecia.
💡 한 문장 핵심
남성 안드로겐성 탈모.
5/5 보강
TL;DR
Androgenetic alopecia is a progressive condition and although the current available treatments are effective in arresting the progression of the disease, they allow only partial regrowth of hair at its best.
📑 코퍼스 인용 관계
· 인용됨 42
📑 인용한 논문 (6) ▾
- Beyond the Follicle: A Narrative Review on How Systemic Diseases and Drugs Affect Alopecia… Pharmaceutical medicine · 2026
- Efficacy and Safety of Low-Dose (0.2 mg) Dutasteride for Male Androgenic Alopecia: A Multi… Annals of dermatology · 2025
- Male and female pattern hair loss. Australian prescriber · 2025
- Nanocrystal Structure of Minoxidil: A Safe Stimulator for Hair Growth Factor for C57BL/6 M… Current medicinal chemistry · 2025
- Modulating immune responses in alopecia: therapeutic insights and potential targets of ant… BMC immunology · 2025
- Adenosine as an Active Ingredient in Topical Preparations Against Hair Loss: A Systematic … Biomolecules · 2025
연도별 인용 (2012–2026) · 합계 155
OpenAlex 토픽 ·
Hair Growth and Disorders
Sexual Differentiation and Disorders
Acne and Rosacea Treatments and Effects
🇰🇷 한글 요약 🌐 Abstract
【연구 목적】
남성형 탈모(male androgenetic alopecia, AGA)의 병태생리와 유전적 배경, 그리고 현재 사용 가능한 치료법을 종합적으로 검토하는 것을 목적으로 한 리뷰 논문입니다.
【방법】
남성형 탈모의 역학, 모낭 소형화(follicular miniaturization) 기전, 안드로겐 수용체 유전자 다형성 및 신규 감수성 유전자(3q26, 20p11), 약물치료와 모발이식술(hair transplant)에 관한 문헌을 고찰하였습니다.
【주요 결과】
80세까지 남성의 최대 80%가 영향을 받으며, 안드로겐 의존 경로 외에도 비안드로겐 의존 경로의 관여가 시사됩니다. FDA 승인 치료제로 국소 미녹시딜(topical minoxidil)과 경구 피나스테리드(oral finasteride)가 사용되며, 두타스테리드(dutasteride, 제1·2형 5-알파환원효소 억제제)는 3상에서 보류 상태입니다. 약물치료와 모발이식술의 병행이 단독 치료보다 우수한 효과를 보였습니다.
【임상적 시사점 (성형외과 의사 관점)】
탈모는 진행성 질환으로 현재 치료는 진행 억제와 부분 재성장에 그치므로 조기 개입이 핵심이며, 환자 상담 시 이를 명확히 전달해야 합니다. 모발이식술 단독보다 미녹시딜·피나스테리드 등 내과적 치료와의 병행 프로토콜이 임상 결과를 극대화하므로, 수술 전후 약물요법을 표준 패키지로 구성하는 것이 권장됩니다.
[IMPORTANCE OF THE FIELD] Androgenetic alopecia affects up to 80% of males by the age of 80. The synonym 'male-pattern hair loss' highlights the fact that hair loss occurs in a defined and reproducible pattern. Hair loss results in reduced self esteem, loss of confidence and anxiety in affected men. An effective treatment for hair baldness would be desirable.
[AREAS COVERED IN THIS REVIEW] In androgenetic alopecia, hair follicles undergo progressive miniaturization. Genetic factors and androgens play a major role in the pathogenesis of the disease. Polymorphism of the androgen receptor gene was first identified in association with androgenetic alopecia. Identification of new susceptibility genes on chromosomes 3q26 and 20p11 suggest that non-androgen-dependent pathways also are involved.
[WHAT THE READER WILL GAIN] Topical monoxidil and oral finasteride are commonly in use and have FDA approval for the treatment of male androgenetic alopecia; dutasteride, a type I and II 5-alpha-reductase inhibitor, is on hold in Phase III trials. A combination of medical treatment and hair transplant surgery has shown superior efficacy.
[TAKE-HOME MESSAGE] Androgenetic alopecia is a progressive condition and although the current available treatments are effective in arresting the progression of the disease, they allow only partial regrowth of hair at its best. Early treatment achieves the best desirable outcome.
[AREAS COVERED IN THIS REVIEW] In androgenetic alopecia, hair follicles undergo progressive miniaturization. Genetic factors and androgens play a major role in the pathogenesis of the disease. Polymorphism of the androgen receptor gene was first identified in association with androgenetic alopecia. Identification of new susceptibility genes on chromosomes 3q26 and 20p11 suggest that non-androgen-dependent pathways also are involved.
[WHAT THE READER WILL GAIN] Topical monoxidil and oral finasteride are commonly in use and have FDA approval for the treatment of male androgenetic alopecia; dutasteride, a type I and II 5-alpha-reductase inhibitor, is on hold in Phase III trials. A combination of medical treatment and hair transplant surgery has shown superior efficacy.
[TAKE-HOME MESSAGE] Androgenetic alopecia is a progressive condition and although the current available treatments are effective in arresting the progression of the disease, they allow only partial regrowth of hair at its best. Early treatment achieves the best desirable outcome.
【연구 목적】 남성형 탈모(male androgenetic alopecia, AGA)의 병태생리와 유전적 배경, 그리고 현재 사용 가능한 치료법을 종합적으로 검토하는 것을 목적으로 한 리뷰 논문입니다.
APA 7
Rathnayake, D., & Sinclair, R. (2010). Male androgenetic alopecia.. Expert opinion on pharmacotherapy, 11(8), 1295-304. https://doi.org/10.1517/14656561003752730
Vancouver
Rathnayake D, Sinclair R. Male androgenetic alopecia. Expe. opin. phar.. 2010;11(8):1295-304. doi:10.1517/14656561003752730
AMA 11
Rathnayake D, Sinclair R. Male androgenetic alopecia. Expe. opin. phar.. 2010;11(8):1295-304. doi:10.1517/14656561003752730
Chicago
Rathnayake, D., and Sinclair, R.. 2010. "Male androgenetic alopecia." Expert opinion on pharmacotherapy 11 (8): 1295-304. https://doi.org/10.1517/14656561003752730
MLA 9
Rathnayake, D., and Sinclair R. "Male androgenetic alopecia." Expert opinion on pharmacotherapy, vol. 11, no. 8, 2010, pp. 1295-304. doi:10.1517/14656561003752730.
PMID
20426708 ↗
🏷️ 키워드 / MeSH 📖 같은 키워드 OA만
인용 관계
그래프 OA 노드: 8/8 (100%)
· 참조 0편 · 후속 8편
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