Comorbidities in alopecia areata: A systematic review and meta-analysis.
💡 한 문장 핵심
원형탈모증의 동반질환: 체계적 문헌고찰 및 메타분석.
메타분석
5/5 보강
TL;DR
Alopecia areata is associated with various systemic and psychiatric diseases and Physicians are encouraged to evaluate and manage potential comorbid conditions to achieve better outcomes.
PICO 자동 추출 (휴리스틱, conf 2/4)
유사 논문P · Population 대상 환자/모집단
환자: AA and quantify their prevalence and odds and hazard ratios compared with those in controls without AA
I · Intervention 중재 / 시술
추출되지 않음
C · Comparison 대조 / 비교
추출되지 않음
O · Outcome 결과 / 결론
[CONCLUSION] AA is associated with various systemic and psychiatric diseases. Physicians are encouraged to evaluate and manage potential comorbid conditions to achieve better outcomes.
📑 코퍼스 인용 관계
· 인용됨 81
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🇰🇷 한글 요약 🌐 Abstract
【연구 목적】
원형 탈모증(Alopecia areata, AA) 환자에서 동반되는 전신 질환의 유병률과 발생 위험을 비환자군과 비교 정량화하기 위해 시행된 체계적 문헌 고찰 및 메타분석.
【방법】
2018년 2월 28일 이전 MEDLINE, Embase, Web of Science, Cochrane Library에 게재된 관찰 연구를 대상으로 검색하였고, 소아 한정 연구나 검사 수치만 제공한 연구는 제외. 역분산 가중치(inverse variance) 변량효과 모델로 메타분석 시행, 총 87편 분석.
【주요 결과】
AA 환자에서 아토피 질환, 대사증후군, 헬리코박터 파일로리 감염, 루푸스(lupus erythematosus), 철결핍성 빈혈, 갑상선 질환, 정신질환, 비타민 D 결핍, 청각·안과적 이상의 유병률이 유의하게 높았음. 또한 자가면역질환 발생 위험(hazard ratio)도 증가하는 것으로 확인됨.
【임상적 시사점 (성형외과 의사 관점)】
모발이식(hair transplantation) 또는 두피 관련 시술 상담 시 AA 환자에서는 단순 탈모 평가에 그치지 말고 갑상선 기능, 철 결핍, 비타민 D, 아토피·자가면역 병력, 정신과적 동반질환에 대한 스크리닝을 권고. 특히 활동성 자가면역 환경에서는 이식 모낭 생착률 저하 및 재발성 탈모 위험이 있으므로 시술 전 안정화 및 피부과 협진을 고려하고, 우울·불안 동반 가능성을 감안한 심리적 상담도 함께 진행하는 것이 바람직함.
[BACKGROUND] Alopecia areata (AA) may be associated with various systemic diseases according to several studies.
[OBJECTIVE] To identify prevalent and incident diseases in patients with AA and quantify their prevalence and odds and hazard ratios compared with those in controls without AA.
[METHODS] A systematic review of the studies published before February 28, 2018, was performed by using the MEDLINE, Embase, Web of Science, and Cochrane Library databases. Observational studies on prevalent or incident diseases in patients with AA were included, whereas studies limited to pediatrics or providing only laboratory results or continuous data were excluded. The inverse variance method with a random-effects model was used for meta-analyses.
[RESULTS] A total of 87 studies were analyzed. Atopic diseases, metabolic syndrome, Helicobacter pylori infection, lupus erythematosus, iron deficiency anemia, thyroid diseases, psychiatric diseases, vitamin D deficiency, and audiologic and ophthalmic abnormalities were more prevalent in patients with AA. Patients with AA had a higher risk of developing autoimmune diseases.
[LIMITATIONS] Some diseases were investigated by an insufficient number of studies to be meta-analyzed. Meta-analysis of incident diseases was not performed owing to the limited availability of cohort studies.
[CONCLUSION] AA is associated with various systemic and psychiatric diseases. Physicians are encouraged to evaluate and manage potential comorbid conditions to achieve better outcomes.
[OBJECTIVE] To identify prevalent and incident diseases in patients with AA and quantify their prevalence and odds and hazard ratios compared with those in controls without AA.
[METHODS] A systematic review of the studies published before February 28, 2018, was performed by using the MEDLINE, Embase, Web of Science, and Cochrane Library databases. Observational studies on prevalent or incident diseases in patients with AA were included, whereas studies limited to pediatrics or providing only laboratory results or continuous data were excluded. The inverse variance method with a random-effects model was used for meta-analyses.
[RESULTS] A total of 87 studies were analyzed. Atopic diseases, metabolic syndrome, Helicobacter pylori infection, lupus erythematosus, iron deficiency anemia, thyroid diseases, psychiatric diseases, vitamin D deficiency, and audiologic and ophthalmic abnormalities were more prevalent in patients with AA. Patients with AA had a higher risk of developing autoimmune diseases.
[LIMITATIONS] Some diseases were investigated by an insufficient number of studies to be meta-analyzed. Meta-analysis of incident diseases was not performed owing to the limited availability of cohort studies.
[CONCLUSION] AA is associated with various systemic and psychiatric diseases. Physicians are encouraged to evaluate and manage potential comorbid conditions to achieve better outcomes.
- 연구 설계 systematic review
【연구 목적】 원형 탈모증(Alopecia areata, AA) 환자에서 동반되는 전신 질환의 유병률과 발생 위험을 비환자군과 비교 정량화하기 위해 시행된 체계적 문헌 고찰 및 메타분석.
APA 7
Lee, S., Lee, H., Lee, C. H., & Lee, W. S. (2019). Comorbidities in alopecia areata: A systematic review and meta-analysis.. Journal of the American Academy of Dermatology, 80(2), 466-477.e16. https://doi.org/10.1016/j.jaad.2018.07.013
Vancouver
Lee S, Lee H, Lee CH, Lee WS. Comorbidities in alopecia areata: A systematic review and meta-analysis. Jour. Amer. Acad. Derm.. 2019;80(2):466-477.e16. doi:10.1016/j.jaad.2018.07.013
AMA 11
Lee S, Lee H, Lee CH, Lee WS. Comorbidities in alopecia areata: A systematic review and meta-analysis. Jour. Amer. Acad. Derm.. 2019;80(2):466-477.e16. doi:10.1016/j.jaad.2018.07.013
Chicago
Lee, S., Lee, H., Lee, C. H., and Lee, W. S.. 2019. "Comorbidities in alopecia areata: A systematic review and meta-analysis." Journal of the American Academy of Dermatology 80 (2): 466-477.e16. https://doi.org/10.1016/j.jaad.2018.07.013
MLA 9
Lee, S., et al. "Comorbidities in alopecia areata: A systematic review and meta-analysis." Journal of the American Academy of Dermatology, vol. 80, no. 2, 2019, pp. 466-477.e16. doi:10.1016/j.jaad.2018.07.013.
PMID
30031145 ↗
추출된 의학 개체 (NER)
합병증
감염 infection
전체 NER 표 보기
| 유형 | 영어 표현 | 한국어 / 풀이 | UMLS CUI | 출처 | 등장 |
|---|---|---|---|---|---|
| 질환 | alopecia areata
|
원형 탈모증 | dict | 2 | |
| 합병증 | infection
|
감염 | dict | 1 |
🏷️ 키워드 / MeSH 📖 같은 키워드 OA만
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그래프 OA 노드: 7/8 (88%)
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