Daphnoretin targeted binding to HSP90AA1 to promote P53 UFMylation and stability thereby inducing apoptosis in colorectal cancer.
2/5 보강
OpenAlex 토픽 ·
Bioactive Natural Diterpenoids Research
Cell death mechanisms and regulation
Microbial Natural Products and Biosynthesis
ℹ️ 이 논문은 무료 전문이 아직 없습니다. 코퍼스 전체의 43.9%는 무료 가능 (통계 →) · 🏥 기관 EZproxy로 시도
[BACKGROUND] Daphnoretin (DAP), the principal bioactive constituent isolated from the traditional Chinese medicinal herb Wikstroemia indica rasix (WIR), exhibits well-documented pharmacological proper
APA
Lianghe Li, Lei Li, et al. (2026). Daphnoretin targeted binding to HSP90AA1 to promote P53 UFMylation and stability thereby inducing apoptosis in colorectal cancer.. Phytomedicine : international journal of phytotherapy and phytopharmacology, 156, 158180. https://doi.org/10.1016/j.phymed.2026.158180
MLA
Lianghe Li, et al.. "Daphnoretin targeted binding to HSP90AA1 to promote P53 UFMylation and stability thereby inducing apoptosis in colorectal cancer.." Phytomedicine : international journal of phytotherapy and phytopharmacology, vol. 156, 2026, pp. 158180.
PMID
42034025 ↗
Abstract 한글 요약
[BACKGROUND] Daphnoretin (DAP), the principal bioactive constituent isolated from the traditional Chinese medicinal herb Wikstroemia indica rasix (WIR), exhibits well-documented pharmacological properties-including anti-inflammatory, antioxidant, immunomodulatory, and antitumor activities. Nevertheless, its molecular mechanism of action in colorectal cancer (CRC) remains incompletely elucidated.
[METHODS] The anti-tumor effect of DAP was verified through in vivo and in vitro models. The potential mechanism of DAP's influence on CRC was explored through network pharmacology analysis. Key targets were screened and the molecular mechanism of DAP's action was verified in vivo and in vitro models. The clinical value of DAP in combination with 5-FU was evaluated in cell models.
[RESULTS] DAP treatment potently suppressed proliferation (240 μg/ml, decreased by 96.6.6%) and migration (240 μg/ml, decreased by 65.6%) of CRC cells in vitro, and significantly inhibited both subcutaneous xenograft tumor growth nude mice (decreased by 58.3%) and colonic tumorigenesis in the azoxymethane/dextran sulfate sodium (AOM/DSS)-induced murine CRC model. Network pharmacology analysis screened out 7 key targets, among which HSP90AA1 was confirmed as a key target. Mechanistically, DAP enhances the ubiquitination level of P53 by targeting HSP90AA1, thereby inhibiting its ubiquitination degradation and promoting apoptosis. Additionally, the combination of DAP and 5-fluorouracil (5-FU) can inhibit tumor growth and reduce tumor number.
[CONCLUSION] This study identifies, for the first time, DAP as a functional modulator of the HSP90AA1-P53 axis, thereby elucidating a novel molecular mechanism underlying its anti-colorectal cancer activity. These findings provide a mechanistically grounded rationale for the synergistic combination of DAP-a natural bioactive compound derived from traditional Chinese medicine-with standard chemotherapeutic agents, and underscore its strong translational potential in oncology.
[METHODS] The anti-tumor effect of DAP was verified through in vivo and in vitro models. The potential mechanism of DAP's influence on CRC was explored through network pharmacology analysis. Key targets were screened and the molecular mechanism of DAP's action was verified in vivo and in vitro models. The clinical value of DAP in combination with 5-FU was evaluated in cell models.
[RESULTS] DAP treatment potently suppressed proliferation (240 μg/ml, decreased by 96.6.6%) and migration (240 μg/ml, decreased by 65.6%) of CRC cells in vitro, and significantly inhibited both subcutaneous xenograft tumor growth nude mice (decreased by 58.3%) and colonic tumorigenesis in the azoxymethane/dextran sulfate sodium (AOM/DSS)-induced murine CRC model. Network pharmacology analysis screened out 7 key targets, among which HSP90AA1 was confirmed as a key target. Mechanistically, DAP enhances the ubiquitination level of P53 by targeting HSP90AA1, thereby inhibiting its ubiquitination degradation and promoting apoptosis. Additionally, the combination of DAP and 5-fluorouracil (5-FU) can inhibit tumor growth and reduce tumor number.
[CONCLUSION] This study identifies, for the first time, DAP as a functional modulator of the HSP90AA1-P53 axis, thereby elucidating a novel molecular mechanism underlying its anti-colorectal cancer activity. These findings provide a mechanistically grounded rationale for the synergistic combination of DAP-a natural bioactive compound derived from traditional Chinese medicine-with standard chemotherapeutic agents, and underscore its strong translational potential in oncology.
🏷️ 키워드 / MeSH 📖 같은 키워드 OA만
같은 제1저자의 인용 많은 논문 (5)
- The Role of Probiotics , , and in Inhibziting Pathogens, Maintaining Gut Health, and Improving Disease Outcomes.
- Ziyuglycoside II ameliorates chemotherapy-induced neutropenia by promoting neutrophil differentiation and functional recovery via SPI1 and C/EBPϵ transcriptional regulation.
- Tumor-specific glyco-detonators: A neuraminidase-3-gated programmable DNA Nanoarchitectonics for liver cancer-exclusive chemotherapy.
- Absence of independent prognostic impact of node status in M1 prostate cancer: implications from a SEER-based study.
- Correction: Let-7b-5p inhibits breast cancer cell growth and metastasis via repression of hexokinase 2-mediated aerobic glycolysis.
🏷️ 같은 키워드 · 무료전문 — 이 논문 MeSH/keyword 기반
- The role of disulfidptosis-driven tumor microenvironment remodeling in pancreatic cancer progression.
- A herbal formulation inhibits growth and survival of lung cancer cells through DNA damage and apoptosis - in vitro and in vivo studies.
- Mitocurcumin induces ROS-/JNK-mediated paraptosis to overcome chemoresistance in non-small cell lung cancer.
- Venetoclax induces mitochondrial apoptosis and autophagy to overcome arsenic trioxide resistance in acute promyelocytic leukemia.
- Opposing prognostic roles of tumor-associated and circulating MMP8 in colorectal cancer.
- Copper-enriched zinc peroxides induced cuproptosis through concurrent metabolic and oxidative dysregulation for boosting immunotherapy in colorectal cancer.