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65건 · 최신순-
Therapeutic Efficacy and Safety of Recombinant Botulinum Toxin Type A for Moderate to Severe Glabellar Lines: A Randomized, Controlled, Double-blind, Phase III Trial in Chinese Adults.
[BACKGROUND] Conventional botulinum toxin type A (BoNT/A) products include non-therapeutic accessory proteins vary in composition and manufacturing processes, which may contribute to differences in purity and biochemical characteristics. YY…
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Botulinum Toxin Type A in the Treatment of Primary Axillary Hyperhidrosis:A Phase 3, Multicenter, Randomized, Double-Blind, Placebo-Controlled Study of Efficacy and Safety in Chinese Patients.
[BACKGROUND] The efficacy and safety of botulinum toxin type A (BoNTA) treatment for primary axillary hyperhidrosis (PAH) have not been explored in the Chinese population. [OBJECTIVES] The objective was to evaluate efficacy and safety of 1…
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Current Evidence of the Effect of Breastfeeding on Ear Molding Outcomes: A Scoping Review.
[OBJECTIVE] To provide an overview on auricular molding and to investigate whether breastfeeding is associated with greater cartilage malleability or improved perinatal auricular molding outcomes. [DATA SOURCES] Embase, MEDLINE, and CENTRA…
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Clinical Efficacy Analysis of Functional Rhinoplasty Assisted by Nasal Endoscopy.
[OBJECTIVE] To analyze the clinical effect of endoscopy-assisted functional rhinoplasty. [METHODS] Endoscopy-assisted functional rhinoplasty was performed in all patients. Deviated nasal septum was corrected, nasal septum cartilage graft w…
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Novel Clinical Insights into the Pathogenesis of Posttraumatic Elbow Stiffness: An Expression Profile Analysis of Contracted Joint Capsule in Human.
[BACKGROUND] Posttraumatic elbow stiffness is a complex complication with two characteristics of capsular contracture and heterotopic ossification. Currently, genomic mechanisms and pathogenesis of posttraumatic elbow stiffness remain inade…
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Recent developments in delirium after oral and maxillofacial free-flap reconstruction.
Postoperative delirium (POD), a common complication following surgery and anesthesia, is particularly prone to occur after reconstruction surgery in the oral and maxillofacial region. The occurrence of POD seriously affects the incidence of…
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Narrow-Margin Treatment with Modified Mohs Microsurgery for Extramammary Paget's Disease: A Retrospective Clinical Analysis.
[BACKGROUND] To investigate the clinical efficacy of narrow-margin modified Mohs microsurgery (mMMS) in the treatment of extramammary Paget's disease (EMPD). [METHODS] A retrospective cohort review was conducted on 52 patients with EMPD wh…
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Developing a predictive nomogram model for incidence of adverse outcomes in oral and maxillofacial tumor patients undergoing free flap reconstruction.
[BACKGROUND] Surgical treatment of oral and maxillofacial tumors is complex, and the factors contributing to adverse outcomes remain incompletely understood. This study aimed to identify independent risk factors and develop an efficient nom…
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Clinical outcomes and urodynamic analysis of microsurgery combined with multilayer fascial tissue coverage for new urethra in the treatment of hypospadias in male children.
[OBJECTIVE] To compare and analyze differences in the clinical effect and postoperative urodynamic indexes of microsurgery combined with covering new urethra by multilayer fascial tissue coverage tissues and conventional surgery alone in th…
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Comparative analysis of the therapeutic effect of antibiotic bone cement on Wagner grade 3 or 4 diabetic foot ulcer in heel and non-heel areas: a retrospective cohort study.
[BACKGROUND] Heel diabetic foot ulcers (hDFU) represent a particularly severe form of DFU, characterized by prolonged healing times and a significantly elevated risk of major amputation. Effective strategies to control infection and improve…
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Correction: Comparative analysis of the therapeutic effect of antibiotic bone cement on Wagner grade 3 or 4 diabetic foot ulcer in heel and non-heel areas: a retrospective cohort study.
[This corrects the article DOI: 10.3389/fendo.2025.1662731.].…
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Liangxue Qushi Zhiyang Decoction Inhibits Atopic Dermatitis in Mice via FcR-Mediated Phagocytosis.
Liangxue Qushi Zhiyang Decoction (LQZ) is a traditional formula known for its efficacy in treating Atopic Dermatitis (AD). However, the specific mechanisms through which LQZ alleviates AD symptoms remain largely unknown. The objective of th…
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Acute-onset Concomitant Esotropia in Children: A Comparison of Clinical Features and Treatment Outcomes.
[PURPOSE] To evaluate and compare the clinical features and efficacy of botulinum toxin A (BTX-A) injection versus surgery in acute-onset concomitant esotropia (ACE) in children. [METHODS] This retrospective comparative clinical study was …
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Real-world large sample evaluation of drug-related blepharoptosis: a pharmacovigilance analysis of the FDA Adverse Event Reporting System database.
[BACKGROUND] Blepharoptosis is one of the most common eyelid disorders in clinical ophthalmology. Previous evidence on drug-related blepharoptosis limited to case reports. [OBJECTIVES] This study aims to systematically evaluate the disprop…
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Comparison of the different operation room environmental exposures on tear film function before and after operation.
1.2 Previous studies have confirmed that air and light pollution can cause damage to a number of systems throughout the body, including the ocular surface and retina. However, the exact effect of air pollution and light pollution on tear fi…
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Evaluating the efficacy and safety of various flaps in Autologous Breast Reconstruction: a Bayesian network meta-analysis.
[AIM] This analysis evaluates the efficacy and safety of different flap techniques for Autologous Breast Reconstruction by collecting all clinical trials employing these methods and applying a Bayesian network meta-analysis. [MATERIALS AND…
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Variant of internal jugular vein reconstruction in bilateral radical neck dissection.
[BACKGROUND] The internal jugular vein (IJV) plays a major role in collecting venous blood from the cranium, face, and neck. Preserving or reconstructing at least one IJV during bilateral radical neck dissection (RND) allows preventing seve…
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The S-Nitrosylation of Septin2 (SNO-Septin2) axis: A novel potential therapeutic target for treating aneurysms and dissection.
Aortic aneurysm and aortic dissection (AAD) are severe life-threatening cardiovascular disorders for which no approved pharmaceutical therapies are currently available. Protein S-nitrosylation (SNO) is a typical redox-dependent posttranslat…
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[Clinical observation of botulinum toxin A injection in the treatment of acute comitant esotropia: a retrospective cohort study].
To observe the efficacy and safety of botulinum toxin A (BTA) injection in the treatment of acute comitant esotropia (ACE) with different doses. This retrospective cohort study included data from patients with ACE who received BTA injectio…
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Efficacy of type A botulinum toxin treatment for androgenetic alopecia using ultrasound combined with trichoscopy.
[OBJECTIVE] This study aimed to assess the efficacy of type A botulinum toxin treatment for androgenetic alopecia (AGA) using a combination of ultrasound and trichoscopy. [METHODS] Ninety patients with AGA who visited the Department of Der…
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Long-Term Effects of Botulinum Toxin A Versus Incisional Surgery for Management of Partially Accommodative Esotropia in Children: Comparison of Three Approaches.
[PURPOSE] To compare the effect of bilateral medial rectus injection of botulinum toxin A (BTX-A), bilateral medial rectus muscle recession surgery (BMR rc), or unilateral medial rectus muscle recession combined with lateral rectus muscle r…
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DaxibotulinumtoxinA for injection to treat moderate or severe glabellar lines: A randomized, multicenter, Phase III, double-blind, placebo-controlled trial in China.
[BACKGROUND] DaxibotulinumtoxinA for injection (DAXI), a novel botulinum toxin type A formulation, is FDA-approved for glabellar lines treatment. Its clinical efficacy has been demonstrated in two Phase III trials (SAKURA 1 and SAKURA 2). …
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Comparative analysis of surgical modalities for the gynecomastia treatment: efficiency and aesthetic outcomes.
This retrospective study rigorously compares the clinical efficacy of three surgical methodologies for treating gynecomastia while providing guidance for future surgical modality selection. We analyzed records of 77 gynecomastia patients tr…
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Clinical efficacy of flap transfer coverage in the treatment of vesicovaginal fistula.
[INTRODUCTION AND HYPOTHESIS] Vesicovaginal fistula (VVF) brings severe psychological, physiological, and social stress to patients, which seriously affects the quality of their sexual life. Traditional transvaginal repair surgery can cause…
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Embolization of midbrain arteriovenous malformation fed by the artery of Percheron in a child, the first case report and literature review.
[BACKGROUND] Artery of Percheron (AOP) as main feeder artery of arteriovenous malformation (AVM) is extremely rare. Two cases of thalamic AVM fed by AOP have been reported to date and only one AVM been removed by microsurgery when attempt o…
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Vitamin D Receptor Activation Targets ROS-Mediated Crosstalk Between Autophagy and Apoptosis in Hepatocytes in Cholestasic Mice.
[BACKGROUND & AIMS] Observational epidemiologic studies have associated vitamin D deficiency with cholestasis. We reported previously that activation of the vitamin D/vitamin D receptor (VDR) axis in cholangiocytes mitigates cholestatic liv…
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Intradermal Botulinum Toxin A Injection for Scalp Sebum Secretion Regulation: A Multicenter, Randomized, Double-Blinded, Placebo-Controlled, Prospective Study in Chinese Subjects.
[BACKGROUND] Although botulinum toxin type A (BTX-A) injection has been proved to reduce topical sebum secretion, the impact of intradermal BTX-A injection on scalp sebum production has never been reported. [OBJECTIVES] The purpose of this…
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Efficacy and Safety of AbobotulinumtoxinA for the Treatment of Glabellar Lines in Chinese Patients: A Pivotal, Phase 3, Randomized, Double-Blind and Open-Label Phase Study.
[BACKGROUND] Various botulinumtoxinA formulations are approved for glabellar lines treatment worldwide, including abobotulinumtoxinA (Dysport). [OBJECTIVES] Assess abobotulinumtoxinA superiority versus placebo and non-inferiority versus ac…
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Long-Term Effects of Botulinum Toxin A for Horizontal Concomitant Strabismus in Chinese Children.
[INTRODUCTION] For childhood strabismus, early surgical intervention improves both motor and sensory outcomes. Botulinum toxin type A (BTX-A) injection is an alternative to incisional surgery that is fast, less invasive, and preserves a mor…
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Mechanical loading and autophagy: A study on the BoNT-A injection-induced condylar cartilage degeneration.
Botulinum toxin A (BoNT-A) has emerged as a treatment option for temporomandibular disorder (TMD). By injecting BoNT-A into the masseter muscle, it is possible to reduce mechanical loading on the temporomandibular joint (TMJ). However, nume…