논문 목록
26건-
Adverse reactions of PD-1/PD-L1 inhibitors in cancer: FAERS database analysis and protocols to mitigate immune-related events in elderly patients and when using pembrolizumab and atezolizumab.
[OBJECTIVE] This study aimed to characterize adverse drug reactions (ADRs) associated with programmed death-1/programmed death-ligand 1 (PD-1/PD-L1) inhibitors in cancer immunotherapy, identifying demographic, pharmacological, and clinical …
-
Impact of marital status on survival in patients with follicular lymphoma.
Although marital status has been associated with survival in several cancers, evidence regarding its prognostic relevance in follicular lymphoma (FL), an indolent lymphoma characterized by prolonged survival, remains limited. In this popula…
-
14,15-epoxyeicosatrienoic acid drives intestinal adenoma growth and its value as an early biomarker for intestinal adenoma occurrence.
Intestinal adenomas are premalignant lesions that develop into colorectal cancer (CRC), yet the metabolic pathways underlying their malignant transformation remain poorly characterized. Using targeted metabolomics via ultra performance liqu…
-
Multicenter machine learning study for long-term prediction of acute kidney injury after complete mesocolic excision: integrating inflammatory biomarkers and transfusion-related risk factors.
[BACKGROUND] Complete mesocolic excision (CME) is a technically complex and highly invasive surgical approach, and patients undergoing CME are consequently at elevated risk of postoperative acute kidney injury (AKI). Despite this vulnerabil…
-
Disulfide-Bridged Ru Complex-Mediated Photo-Disulfidptosis for Colorectal Cancer Therapy.
Despite numerous therapeutic strategies targeting specific programmed cell death pathways, effectively eliminating malignant colorectal cancer (CRC) remains a significant challenge. Disulfidptosis, a newly identified form of cell death, is …
-
Histone Deacetylase Inhibitor Entinostat Exerts Anti-NSCLC Effects Through the EGFR Signaling Pathway and MDM2-p53 Axis.
[INTRODUCTION] Non-small cell lung cancer (NSCLC) is among the most aggressive malignancies threatening human health. Histone deacetylase inhibitors (HDACi) have been shown to suppress epidermal growth factor receptor (EGFR) signaling, maki…
-
Integrated CTC Enrichment and Dual-Responsive Nanoprobe Identification Enable Intelligent Liquid Biopsy-Based Cancer Diagnosis.
This work addresses the challenge of accurately identifying living circulating tumor cell (CTC) from contaminating leukocytes by developing a novel, fixation-free dual-marker sensing strategy that preserves cell viability and biomolecular i…
-
Role and Mechanism of Scopoletin in Regulating HIF-1α/BNIP3 Cascade to Mediate Autophagy in Lung Cancer Proliferation and Metastasis.
Alkaloids may offer significant advantages over other anticancer drugs, but the role of scopoletin in treating lung cancer is still not understood. A549 cells were treated with 6.12 μM scopoletin or 25 μg/mL 5-fluorouracil as positive drugs…
- IGFBP2 promotes immunosuppression by regulating macrophage PD-L1 expression in NEUROD1-high small cell lung cancer.
-
Whole glucan particles enhance immune modulation in combination with TIGIT checkpoint blockade through Dectin-1 activation.
T cell immunoreceptor with Ig and ITIM domains (TIGIT) checkpoint blocking antibodies have been shown to be an immune checkpoint blocking (ICB) therapy for cancer patients. However, the anti-tumor effect of blocking TIGIT alone is limited. …
-
Targeting the tripartite axis of immune-metabolic-spatial crosstalk to overcome therapy resistance in breast cancer.
Therapeutic resistance remains the principal cause of mortality in breast cancer. While the tumor microenvironment (TME) is a key contributor, therapies targeting isolated TME components, whether immune, metabolic, or spatial, have largely …
-
A second near-infrared light-activated nanoplatform with spatiotemporal signal transduction for simultaneous enrichment and portable detection of circulating tumor cells.
Circulating tumor cells (CTCs) serve as the first indicators of early-stage cancer metastasis and are therefore crucial for early cancer diagnosis, therapeutic response monitoring, and prognosis evaluation. However, accurate clinical detect…
-
Intelligent bacterial platform induces programmed death-ligand 1 lysosomal degradation to enhance antitumor immunity.
Engineered bacteria have emerged as a promising therapeutic strategy for tumor therapy by exploiting the unique features of the tumor microenvironment (TME). In this study, we developed a low-endotoxin Escherichia coli expression system to …
-
HerTACs Enable Tumor-Selective Lysosomal Degradation of Membrane and Extracellular Proteins via HER2 Trafficking.
Targeting extracellular and membrane proteins for degradation remains a frontier challenge in the field of targeted protein degradation (TPD), largely due to the intracellular confinement of existing proteolysis systems and reliance on bulk…
-
Real-world efficacy and safety of disitamab vedotin monotherapy or in combination with PD-1 inhibitors in locally advanced or metastatic upper tract urothelial carcinoma: a multicenter retrospective study.
[OBJECTIVE] Disitamab vedotin (RC48) is a HER2-targeted antibody-drug conjugate (ADC) that can induce immunogenic cell death and enhance antitumor immunity. Preclinical data suggest synergistic activity with PD-1 inhibitors, but its benefit…
-
Radiotherapy alone versus combined therapy in stage I natural killer/T-cell lymphoma: impact of local invasion on treatment outcomes.
Although combined modality therapy is frequently recommended for early-stage natural killer/T-cell lymphoma (NKTCL), the additional benefit of chemotherapy over radiation therapy (RT) alone in stage I disease remains unclear. We retrospecti…
-
Molecular function validation and prognostic value analysis of the cuproptosis-related gene ferredoxin 1 in papillary thyroid carcinoma.
Cuproptosis, a copper-dependent distinct form of cell death, holds a critical role in tumor development. However, further investigation is needed to elucidate the impact of the cuproptosis signaling on thyroid cancer. In this study, compreh…
-
Can patients with mild non-neoplastic lesions diagnosed at baseline screening be safely exempt from surveillance: evidence from multicenter community-based cohorts.
Surveillance recommendations for gastric cancer (GC) in current guidelines focused on advanced precancerous lesions and were based on precise diagnosis of severity/extent of baseline lesions. We aimed to develop a less endoscopy-related equ…
-
Systematic analysis identifies CDKN2A as a prognostic biomarker for hepatocellular carcinoma.
[BACKGROUND] Hepatocellular carcinoma (HCC) ranks as the fifth most prevalent malignancy worldwide. Disruptions in copper homeostasis adversely affect liver function. Cuproptosis, a recently defined form of regulated cell death triggered by…
-
Enhancing cyclic peptide functionality with hydrophilic diamino acids for improved APC-Asef interaction inhibition.
Cyclic peptides inherently possess advantages in inhibiting protein-protein interactions (PPIs). However, those constructed using traditional disulfide bonds are susceptible to cleavage by disulfide isomerase or reducing environments, leadi…
-
A high-throughput screening approach to discover potential colorectal cancer chemotherapeutics: repurposing drugs to identify novel disruptors of 14-3-3 proteins.
Selectively inducing apoptosis of cancer cells is an effective therapeutic strategy, but the success of existing chemotherapeutics is compromised by emergent tumor cell resistance and systemic off-target effects. Therefore, the discovery of…
-
HBV antigen as a tumour antigen in adoptive TCR-T cell therapy for HBV-related HCC: rationale and clinical effectiveness.
Hepatocellular carcinoma developing in patients with HBV chronic infection are marked by expression of whole or partial HBV antigens through a highly tissue-specific process, determined by the hepatotropism of HBV. HBV antigens are therefor…
-
Entropy-driven signal amplification integrated with machine learning in multiplex lateral flow immunoassay for sensitive Point-of-Care colon cancer diagnosis.
Investigations on epithelial-mesenchymal transition (EMT) events occurring on circulating tumor cells (CTCs) are poised to significantly advance nanoliquid biopsy methodologies. This study presented a colorimetric multiplex lateral flow imm…
-
Bridging tradition and innovation: electroacupuncture's impact on premature ovarian insufficiency.
Premature ovarian insufficiency (POI) refers to the decline in ovarian function in women before the age of 40, which can lead to premature ovarian failure and ultimately lead to infertility. In recent years, the incidence of POI has continu…
-
Personalized starting age of gastric cancer screening based on individuals' risk profiles: a population-based, prospective study.
[BACKGROUND] The current recommended starting age for gastric cancer screening lacks unified guideline and individualized criteria. We aimed to determine the risk-stratified starting age for gastric cancer screening in China based on indivi…
-
Single-Surgeon Experience for Maximizing Outcomes in Implant-Based Breast Reconstruction in Chinese Patients.
[INTRODUCTION] Breast reconstruction for Chinese patients is vastly different given cultural differences, patient preferences, access to resources, and insurance coverage in China. Given these unique factors, a different approach for optimi…