전체 논문 (122편 · 1/5)
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An IL-12 partial agonist sustains intratumoral lymphocyte activation and detoxifies systemic IL-12 therapy.
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Immunopeptidomics combined with full-length transcriptomics uncovers diverse neoantigens.
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A human tumor-immune organoid model of glioblastoma.
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PD-L1 is an intrinsic switch for natural killer cell-mediated, TRAIL-dependent antiviral function.
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Cell confinement initiates a delayed but heritable loss of chromosomes.
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Innate imprinting of transcriptional trajectories governs respiratory T fate and persistence.
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Expansion and mobilization of virus-specific stem-like CD8 T cells in chronic viral infection after treatment with a long-acting IL-7, NT-I7.
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Requirements for development of T helper 1 and T follicular helper cells from a common precursor.
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Intestinal low-abundant bacteria drive MyD88/Trif-dependent CD8 T cell exhaustion in chronic myeloid leukemia.
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Metformin hijacks AMPK-ERK1/2 signaling to trigger a pathogenic "selection trap" and thymic atrophy.
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Retinal determination network reactivation drives chemoresistance and blocks myeloid differentiation in acute myeloid leukemia.
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ACSL4-associated lipid metabolism is a distinct therapeutic vulnerability in KMT2A-rearranged acute myeloid leukemia.
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Local heterochromatin enrichment promotes telomere clustering and PML nuclear body assembly at telomeres.
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Targeting UGCG sensitizes AML cells to venetoclax through RAB32-mediated endoplasmic reticulum-mitochondria communication.
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FASN inactivation-induced progranulin (GRN) expression promotes lysosome-dependent cell death to suppress leukemogenesis.
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Early-life B cell memory is archived in the mouse B-1 cell compartment and drives chronic lymphocytic leukemia-like disease.
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Hyperdiploidy impairs fetal hematopoietic progenitor fitness and differentiation enabling persistence of rare preleukemic aneuploid clones.
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Targeting systemic and tumor metabolic balances with ketogenic diets enhance efficacy of therapy in FLT3-ITD acute myeloid leukemia.
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In situ multi-modal characterization of pancreatic cancer reveals tumor cell identity as a defining factor of the surrounding microenvironment.
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A Jagged1-regulated hybrid-EMT state identifies pancreatic cancer stem cells.
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Targeting PI3Kδ suppresses pancreatic cancer by dual disruption of fibrosis and immune evasion.
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Regulatory elements in the Sox9 locus license the initiation of pancreatic ductal adenocarcinoma.
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Tolerance to extracellular acidic pH facilitates tumor plasticity.
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Activated CD38 mast cells promote gastric cancer progression by suppressing CD8 T cell cytotoxic activity through adenosine metabolism.
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Streptococcus anginosus-generated succinate promotes the progression of gastric cancer via the succinate/SUCNR1/ABRAXAS1 axis.
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p57 increases immunotherapy efficacy by promoting cGAS-STING-mediated innate sensing in hepatocellular carcinoma.
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Lysosome-localized IRTKS condensates promote mTORC1 activity leading to MASLD and HCC.
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ESM1 SUMOylation mediates bevacizumab resistance in ovarian cancer through ITGB1-FAK-driven angiogenesis.
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Liprin-α1 enhances PHLDB3 oncogenic function in colorectal cancer via activation of mTORC2-AKT1 pathway.
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Bacterial extracellular vesicle ssRNA prevents colorectal cancer progression via Piezo1.