Local heterochromatin enrichment promotes telomere clustering and PML nuclear body assembly at telomeres.
1/5 보강
The alternative lengthening of telomeres (ALT) pathway is a recombination-based telomere maintenance mechanism used by a subset of human cancers and is characterized by telomere clustering within telo
APA
Taylor ER, Proctor B, et al. (2026). Local heterochromatin enrichment promotes telomere clustering and PML nuclear body assembly at telomeres.. Cell reports, 45(3), 117004. https://doi.org/10.1016/j.celrep.2026.117004
MLA
Taylor ER, et al.. "Local heterochromatin enrichment promotes telomere clustering and PML nuclear body assembly at telomeres.." Cell reports, vol. 45, no. 3, 2026, pp. 117004.
PMID
41712379 ↗
Abstract 한글 요약
The alternative lengthening of telomeres (ALT) pathway is a recombination-based telomere maintenance mechanism used by a subset of human cancers and is characterized by telomere clustering within telomere-associated promyelocytic leukemia (PML) nuclear bodies (APBs). Although ALT telomeres exhibit reduced nucleosome density, they are paradoxically enriched for heterochromatin-associated factors, raising questions about how chromatin state contributes to ALT. Here, we use a targeted system to locally modulate heterochromatin features at telomeres. We show that telomeric heterochromatin promotes telomere clustering and multiple hallmarks of APB-associated telomere processing in ALT-positive (ALT+) cells. Remarkably, molecular tethering of HP1α at telomeres is sufficient to nucleate PML nuclear bodies in non-ALT cells and, in specific contexts, induce biomarkers of ALT-like recombination. We further demonstrate that heterochromatin-driven PML-telomere colocalization is inhibited by α-thalassemia/mental retardation, X-linked and death domain-associated protein (ATRX/DAXX), factors frequently mutated in ALT+ tumors. Together, these findings establish telomeric heterochromatin as a driver of telomere clustering and PML nuclear body assembly, shaping ALT-associated subnuclear compartmentalization.
🏷️ 키워드 / MeSH 📖 같은 키워드 OA만
- Humans
- Heterochromatin
- Telomere
- X-linked Nuclear Protein
- Promyelocytic Leukemia Protein
- Telomere Homeostasis
- Chromobox Protein Homolog 5
- Chromosomal Proteins
- Non-Histone
- Cell Line
- Tumor
- Intranuclear Inclusion Bodies
- Nuclear Proteins
- Molecular Chaperones
- Co-Repressor Proteins
- ALT
- ATRX
- CP: genomics
- PML
- SETDB1
- cancer
- chromatin
- telomeres
🏷️ 같은 키워드 · 무료전문 — 이 논문 MeSH/keyword 기반
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