Intestinal low-abundant bacteria drive MyD88/Trif-dependent CD8 T cell exhaustion in chronic myeloid leukemia.
1/5 보강
Leukemia stem cells (LSCs) resist therapy and immune elimination, but the basis of their escape from cytotoxic T cell (CTL) attack is unclear.
APA
Ronchi F, Hinterbrandner M, et al. (2026). Intestinal low-abundant bacteria drive MyD88/Trif-dependent CD8 T cell exhaustion in chronic myeloid leukemia.. Cell reports, 45(1), 116753. https://doi.org/10.1016/j.celrep.2025.116753
MLA
Ronchi F, et al.. "Intestinal low-abundant bacteria drive MyD88/Trif-dependent CD8 T cell exhaustion in chronic myeloid leukemia.." Cell reports, vol. 45, no. 1, 2026, pp. 116753.
PMID
41442277 ↗
Abstract 한글 요약
Leukemia stem cells (LSCs) resist therapy and immune elimination, but the basis of their escape from cytotoxic T cell (CTL) attack is unclear. Here, we show that specific low-abundance gut commensals of the genera Sutterella and Bilophila suppress anti-leukemic immunity in chronic myeloid leukemia (CML). Germ-free and specific opportunistic pathogen-free mice were protected from CML progression, whereas colonization with Sutterella strains-but not other bacteria-restored disease. In specific pathogen-free CML mice, higher Sutterella prevalence correlated with MyD88/Trif-dependent CTL exhaustion, marked by upregulation of exhaustion markers, reduced interferon-γ and granzyme B production, impaired ex vivo LSC killing, and transcriptomic signatures of exhaustion. These results establish a direct link between the gut microbiota and immune regulation of LSCs, identifying Sutterella species as critical modulators of CTL dysfunction and CML progression. This work highlights microbial influences on cancer immunity and suggests potential therapeutic avenues.
🏷️ 키워드 / MeSH 📖 같은 키워드 OA만
- Animals
- Leukemia
- Myelogenous
- Chronic
- BCR-ABL Positive
- Myeloid Differentiation Factor 88
- Gastrointestinal Microbiome
- Mice
- CD8-Positive T-Lymphocytes
- Inbred C57BL
- Adaptor Proteins
- Vesicular Transport
- Humans
- T-Cell Exhaustion
- CML
- CP: Immunology
- CP: Microbiology
- LSC
- Sutterella
- T cell exhaustion
- gut microbiota
- immune escape
🏷️ 같은 키워드 · 무료전문 — 이 논문 MeSH/keyword 기반
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