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PD-1 blockade promotes mucosal CD4+ T cell IL-10 production through altering microbiota to reduce intestinal ischemia reperfusion injury.
PD-1 blockade therapy is widely used in clinical practice. Intestinal ischemia reperfusion (IR) injury is a serious clinical complication that leads to remote organ damage through disruption of the gut barrier. However, the effects of PD-1 …
FULLTEXT: thyroid dysfunction -
Telomere damage enhances immunogenicity of neuroblastoma and accelerates response to anti-PD-L1 treatment.
Telomerase is active in the majority of high-risk neuroblastomas, a pediatric tumor associated with poor patient outcomes. In other cancer types, resistance to immune checkpoint blockade was overcome by induction of telomere dysfunction usi…
FULLTEXT: thyroid dysfunction -
Identification of the immune-related diagnostic biomarkers between Graves' disease and thyroid carcinoma based on comprehensive bioinformatics analysis and machine learning.
Increasing evidence suggests that Graves' disease (GD) may increase the risk of thyroid cancer (THCA), but diagnostic biomarkers associated with it remain underexplored. To address this issue, we analyzed the Gene Expression Omnibus (GEO) a…
FULLTEXT: thyroid dysfunction -
UCHL5 suppresses thyroid carcinoma progression via ZRANB1 stabilization and ferroptosis regulation.
[OBJECTIVE] This study investigated the role of UCHL5 in thyroid carcinoma (THCA) progression, focusing on its tumor-suppressive mechanisms and regulation of ferroptosis. [METHODS] We performed multi-omics analysis of TCGA and GEO datasets…
FULLTEXT: thyroid dysfunction -
TNF-α deficiency underlies NK cell dysfunction in colorectal cancer.
Natural killer (NK) cells are central to innate antitumor immunity, yet their function is systemically compromised in colorectal cancer (CRC). We show that CRC patients exhibit early and pronounced alterations in peripheral blood NK cells, …
FULLTEXT: thyroid dysfunction -
Endometrial receptivity in polycystic ovary syndrome: altered biomarkers and underlying mechanisms.
Polycystic ovary syndrome (PCOS) is a common endocrine disorder characterized by hyperandrogenism and ovulatory dysfunction. Women with PCOS are at an increased risk for adverse pregnancy outcomes, such as miscarriage and preterm birth. End…
FULLTEXT: thyroid dysfunction -
Real world incidence, predictors and outcomes of endocrine immune-related adverse events following immune checkpoint inhibitors.
Endocrine dysfunction is one of the most common immune-related adverse events (irAEs) reported in immune checkpoint inhibitors (ICIs) clinical trials. The aim of this research was to thoroughly assess the clinical features of endocrine irAE…
FULLTEXT: thyroid dysfunction -
NAD precursor supplementation reverses CD36-mediated lipid accumulation and ferroptosis to restore antitumor function of NK cells in DLBCL.
Natural killer (NK) cells play a key role in the standard treatment of diffuse large B-cell lymphoma (DLBCL). However, NK cells in DLBCL patients frequently display an exhausted phenotype, which is associated with poor clinical outcomes. Th…
FULLTEXT: thyroid dysfunction -
Pre-ablation stimulated thyroglobulin to TSH ratio as a strong predictor of non-generally satisfactory response to initial radioiodine therapy in papillary thyroid carcinoma patients undergoing lateral neck dissection.
[BACKGROUND] The initial response to radioiodine (³I) therapy is a critical determinant of prognosis in papillary thyroid carcinoma (PTC) patients undergoing therapeutic lateral neck dissection (LND). This study aimed to identify predictors…
FULLTEXT: thyroid dysfunction -
A Randomized Trial Evaluating Intraoperative Ischemic Preconditioning of Parathyroid Glands During Total Thyroidectomy: A Signal for Earlier Parathyroid Function Recovery.
[BACKGROUND] Ischemic preconditioning of parathyroid glands (IPCP) is biologically plausible but clinical evidence is limited. In this single-center randomized trial (ChiCTR2000039788), we compared IPCP versus control during total thyroidec…
FULLTEXT: thyroid dysfunction -
Thermal ablation vs. conventional neck dissection for recurrent low-burden lymph node metastasis in thyroid cancer: a dual-center retrospective cohort study.
[OBJECTIVE] To compare ultrasound-guided thermal ablation (TA) with conventional neck dissection (CND) for recurrent low-burden lymph node metastasis (≤3 lesions, 0.7).TA Advantages: Shorter operative time, less blood loss, faster recovery…
FULLTEXT: thyroid dysfunction -
Diagnostic performance and generalizability of a clinical-ultrasound radiomics model for predicting extrathyroidal extension in thyroid carcinoma: a retrospective study.
[BACKGROUND] Ultrasound plays a crucial role in the preoperative evaluation of thyroid carcinoma and its extrathyroidal extension (ETE). This study aims to develop and validate a model integrating ultrasound radiomics and clinical factors f…
FULLTEXT: thyroid dysfunction -
Importance of clinical, ultrasound and cytological characteristics in predicting malignancy in thyroid nodules with indeterminate cytology.
[INTRODUCTION/OBJECTIVES] To identify demographic, ultrasonographic and cytological features that could improve the management of thyroid nodules with indeterminate cytology. [METHODS] From 592 patients with indeterminate cytology (2008-20…
FULLTEXT: thyroid dysfunction -
Durable response of anaplastic thyroid cancer to pembrolizumab combined with chemotherapy: A case report.
Anaplastic thyroid cancer is a notoriously aggressive malignancy with a dismal prognosis, typically associated with a median overall survival of less than one year. Therapeutic alternatives are particularly limited for patients without acti…
FULLTEXT: thyroid dysfunction -
The role of mesencephalic astrocyte-derived neurotrophic factor in digestive diseases.
[BACKGROUND] Mesencephalic astrocyte-derived neurotrophic factor (MANF) is an evolutionarily conserved endoplasmic reticulum (ER)-resident and secreted protein highly expressed in the digestive system. Emerging evidence has highlighted its …
FULLTEXT: thyroid dysfunction -
Tramadol induced hypoxia signaling and paraptosis-like cell death in breast cancer cells via HIF-1α and ATF4 dependent pathways.
[OBJECTIVES] Tramadol, a clinically approved analgesic widely used for managing postoperative pain, has recently been shown to possess anticancer properties in several tumor models, especially in breast cancer. In this study, we explored th…
FULLTEXT: thyroid dysfunction -
TCAB1: a key promoter of tumor growth through telomere maintenance and senescence evasion.
TCAB1 (telomerase Cajal body protein 1), encoded by the WRAP53 gene on chromosome 17p13.1, is a molecular scaffold critical for protein-nucleic acid interactions. In normal cells, TCAB1 plays a pivotal role in localizing telomerase to Cajal…
FULLTEXT: thyroid dysfunction -
The gut microbiota-obesity axis in the pathogenesis and prognosis of breast cancer.
[BACKGROUND] Breast cancer (BC) remains a major global health concern, accounting for 11.7% of all cancer cases and ranking as the second leading cause of female cancer-related deaths worldwide. Increasing evidence highlights the interplay …
FULLTEXT: thyroid dysfunction -
Condensin complexes: from chromatin organization to disease.
Condensin complexes are indispensable for mitotic chromosome condensation. In this review, we summarize their structural and functional features, focusing on ATP-dependent loop extrusion and mitotic chromatin folding. We discuss current mod…
FULLTEXT: thyroid dysfunction -
Expanding the role of thermal ablation in thyroid cancer beyond low-risk unifocal PTMC: a review of the current state and future perspectives.
[BACKGROUND] Thermal ablation (TA) is an established treatment for low-risk unifocal papillary thyroid microcarcinoma (PTMC) and has been incorporated into several clinical guidelines. However, its clinical indications remain limited and do…
FULLTEXT: thyroid dysfunction