논문 검색
검색 결과: 4,191건 SQL fulltext · 📄 CSV ↓ · 📖 OA 45% ›
-
Sialic acid -ligand dynamics modulate Siglec-7 and -9 function and affect Siglec-7/9 co-blockade to potentiate natural killer cell anti-tumor activity.
The glyco-immune checkpoints Siglec-7 and Siglec-9 have received considerable interest as targets for cancer immunotherapy. How Siglec-7/9-sialic acid -interactions on immune cells influence -signaling induced by tumor cells and whether Sig…
FULLTEXT: surface functionalization -
Adaptive immune and platelet activation during the maintenance phase of therapy in adults with B cell acute lymphoblastic leukemia.
[BACKGROUND] Maintenance therapy is an integral component of treatment for B cell acute lymphoblastic leukemia (B-ALL) and has demonstrated clinical efficacy. However, features of immune activation and an increased thrombotic risk may persi…
FULLTEXT: surface functionalization -
Neural network reveals platelet age from fluorescence microscopy images.
Platelets are small, anucleate cells with a primary physiological role in vascular damage repair (hemostasis) and initiation of thrombus formation in response to vascular injury. Platelets circulate approximately 7-10 days, slowly undergoin…
FULLTEXT: surface functionalization -
The mouse gastric surface epithelial cell and its response to early infection.
infection is the main risk factor for gastric cancer. easily develop antibiotic resistance and evade host defenses. In-depth knowledge of the first barrier that encounter, the gastric surface mucus-producing epithelial cells (SMCs), may e…
FULLTEXT: surface functionalization -
Absence of steatosis combined with cardiometabolic risk factors confers the highest hepatocellular carcinoma risk in treated chronic hepatitis B.
[BACKGROUND] Chronic hepatitis B (CHB) is a major cause of hepatocellular carcinoma (HCC). In patients receiving CHB treatment, coexistence of steatotic liver disease (SLD) and cardiometabolic risk factors (CMRFs) markedly influence HCC ris…
FULLTEXT: surface functionalization -
Axillary treatment options in clinically nodes-positive breast cancer whose nodes become pathologically nodes-negative after neoadjuvant chemotherapy: a pairwise and network meta-analysis.
[BACKGROUND] Neoadjuvant chemotherapy (NAC) has increased heterogeneity in regional axillary management. The optimal strategy remains uncertain for patients with clinically node-positive (cN+) breast cancer (BC) who convert to pathologicall…
FULLTEXT: surface functionalization -
Comparison of chemotherapeutic combination therapy, dosing frequency and dosing sequence for the adjuvant treatment of early-stage breast cancer: a network meta-analysis.
[BACKGROUND] Despite the availability of several chemotherapeutic regimens for early-stage breast cancer (BC), the ideal combination and dosing strategy remain to be defined. Thus, we conducted a network meta-analysis (NMA) comparing the cu…
FULLTEXT: surface functionalization -
Comparative efficacy of intralesional therapies for keloid scars: a network meta-analysis.
TL;DRIt is indicated that combination therapies, most notably 5-FU’s+ corticoids’+ YAG:Laser, offer the greatest benefit, and data for novel agents suggest potential, while data for novel agents suggest potential.
FULLTEXT: surface functionalization -
Multi-cell, non-invasive, online monitoring of PLA-coated magnetic nanoparticles uptake by MCF-7 cells using digital holographic microscopy.
The application of nanoparticles (NPs) in medicine as delivery platforms has experienced a significant expansion in the past decade and as a result, various imaging techniques have been applied to monitor cellular NP uptake. Although, high-…
FULLTEXT: surface functionalization -
Smart graphene-enhanced ceramic material refractive index sensor simulation design developed for highly sensitive breast Cancer detection optimized with machine learning.
Based on the surface plasmon resonance (SPR) technique, the proposed biosensor is investigated as an SPR-based sensing platform for detecting breast cancer cells, specifically MCF-7 and MDA-MB-231 cells. Developed biosensor features an octa…
FULLTEXT: surface functionalization -
"Dual-lock" activated nanosystem for colorectal cancer: Defect engineering-driven NIR-II PTT-enhanced ferroptosis to trigger antitumor immunity.
Conventional therapies for colorectal cancer (CRC) are often constrained by limited specificity, while the hypoxic, acidic, and immunosuppressive commonly contributes to immunotherapy resistance. Herein, a dual-responsive nanosystem with ox…
FULLTEXT: surface functionalization -
PAM-assembled CRISPR-Cas12a activation-based fluorescent and colorimetric dual-modal biosensor for detecting prostate cancer exosomes.
Prostate specific membrane antigen (PSMA)-positive exosomes hold significant potential for the diagnosis and risk assessment of prostate cancer. However, accurate detection is severely hindered by their low abundance in blood and interferen…
FULLTEXT: surface functionalization -
A programmable matrix-robust plasmonic MetaRing biosensor for rapid SERS-based chemotherapeutic response profiling.
Rapid assessment of chemotherapeutic response is essential for precision oncology but remains hindered by tumor heterogeneity and complex biological matrices. Here, we develop MetaRing, a programmable coffee-ring-derived plasmonic biosensor…
FULLTEXT: surface functionalization -
UM-6 remodels the tumor immune microenvironment by blocking PD-L1 N-glycosylation and promoting ERAD-mediated degradation in cervical cancer.
Cervical cancer remains a major global health burden. Although PD-1/PD-L1 immune checkpoint blockade has expanded treatment options, durable responses are still limited. One key reason is that tumor cells sustain immunosuppression by mainta…
FULLTEXT: surface functionalization -
Novel design of interleukin-2 derivatives with reversed pH and potent antitumor activity.
Interleukin-2 (IL-2) displays high affinity for IL-2Rα at physiological pH, but low affinity in the acidic tumor microenvironment (TME), which brings side effects and reduces anti-tumor activity. This pH-dependent affinity modulation is att…
FULLTEXT: surface functionalization -
Synthesis of silicon (IV)-based Phthalocyanine N-nucleoside conjugates with absorption, aggregation, solvent effects, and in vitro anticancer activity.
Silicon (IV)-based phthalocyanines (Si(IV)-Pcs) are attractive scaffolds for photodynamic therapy due to their strong absorption in the therapeutic window and tunable photophysical properties. In this work, a novel N-thymidine-silicon(IV) p…
FULLTEXT: surface functionalization -
Spatiotemporal controls of neutrophil extracellular traps boosts neutrophils immunotherapy efficiency against solid tumors.
Neutrophils have emerged as promising candidates for next-generation immunotherapies against solid tumors. However, the physical barrier formed by tumor-induced neutrophil extracellular traps (NETs) significantly restricts the migration and…
FULLTEXT: surface functionalization -
Immunosensors for dual tumor biomarker detection based on ternary electrochemiluminescence using confined CeO nanozyme as Co-reactant enhancers for luminol-O system.
Sensitive and parallel individual detection of multiple tumor biomarkers is critical for early diagnosis and therapeutic monitoring of pancreatic cancer. Herein, a ternary electrochemiluminescence (ECL) system was developed by employing nan…
FULLTEXT: surface functionalization -
Nanostructured electrochemical biosensor modified with a plant-derived protein for serine protease detection in prostate cancer.
This study introduces, for the first time, a bioelectrochemical device utilizing a trypsin inhibitor protein (EcTI) from Enterolobium contortisiliquum seeds, designed to interact with serine proteases, including prostate-specific antigen (P…
FULLTEXT: surface functionalization -
Dual-gold nanoprobe system enables highly sensitive SERS detection of glycosylated CEs1 in HepG-2 cell culture supernatant.
Carboxylesterase 1 (CEs1) is crucial in liver injury and hepatocellular carcinoma (HCC) progression, necessitating rapid, sensitive detection methods for its glycosylated form. This study developed a surface-enhanced Raman scattering (SERS)…
FULLTEXT: surface functionalization