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12건-
Immune checkpoint inhibitor-related myocarditis in patients with thymic epithelial tumors: a retrospective cohort analysis.
[BACKGROUND] Immune checkpoint inhibitor-related myocarditis (ICI-M) is increasingly recognized, but real-world data in thymic epithelial tumors (TET) remain limited. [OBJECTIVE] To evaluate the clinical outcomes, focusing on ICI-M, in pat…
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A comparative evaluation of large language models for simplifying prostate cancer pathology reports: ChatGPT and Gemini.
[OBJECTIVES] To evaluate the application value of three ChatGPT versions and Gemini in pathology report simplification tasks for prostate cancer. [METHODS] This retrospective study assessed GPT-3.5, GPT-4.0, GPT-4o, and Gemini on pathology…
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Induction Chemotherapy Followed by Immunotherapy Increases Pathological Complete Response Rate in dMMR/MSI-H Gastric Cancer: A Retrospective Cohort Study.
[BACKGROUND] Immune checkpoint inhibitor (ICI)-based strategies have become a consensus in the preoperative treatment of mismatch repair-deficient (dMMR)/microsatellite instability-high (MSI-H) gastric cancer (GC). However, the necessity an…
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Microbial metabolite deoxycholic acid inhibits noncancerous NCM460 human colon cell proliferation: an inverse correlation between Bmal1:Clock gene expression and cell apoptosis.
High fat diets increase colonic deoxycholic acid (DCA) concentrations, which induce apoptosis, and subsequently enrich a compensatory DCA-resistant mutant colon cell subpopulation. While circadian Bmal1 and Clock genes are key regulators fo…
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Dual-gold nanoprobe system enables highly sensitive SERS detection of glycosylated CEs1 in HepG-2 cell culture supernatant.
Carboxylesterase 1 (CEs1) is crucial in liver injury and hepatocellular carcinoma (HCC) progression, necessitating rapid, sensitive detection methods for its glycosylated form. This study developed a surface-enhanced Raman scattering (SERS)…
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Economic Evaluation of Inavolisib Combined With Palbociclib-Fulvestrant for PIK3CA-Mutated, HR+/HER2- Advanced Breast Cancer in USA.
ObjectiveInavolisib, a novel highly selective PI3Kα inhibitor, is approved for treating PIK3CA-mutated, hormone receptor-positive/human epidermal growth factor receptor 2-negative advanced breast cancer (PIK3CA-mutated, HR+/HER2- ABC). Give…
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Mapping the Mandibular Lingual Foramina for Safer Chin Surgery: CT Morphometry and Predictive Modeling.
[BACKGROUND] Submental hematoma after genioplasty is rare but can be life-threatening, and current imaging data give limited patient-specific guidance for chin osteotomy design. [METHODS] We combined targeted cadaveric dissection of two pe…
- Harnessing dendritic cells for pancreatic cancer immunotherapy: a novel promising approach.
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Efficacy and safety of radiotherapy in first-line treatment for de novo advanced esophageal cancer in the era of immunochemotherapy: a systematic review and meta-analysis.
[PURPOSE] To evaluate the efficacy and safety of systemic treatment combined with radiotherapy (RT) as the first-line treatment for de novo advanced esophageal cancer (EC). [METHODS] A meta-analysis was conducted, and it followed the Prefe…
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Autologous Fat Injection for Rhinoplasty: A Systematic Review of Satisfaction, Reinjection and Fat Retention.
[BACKGROUND] Autologous fat injection has been proposed as a potential alternative to traditional rhinoplasty. However, the technique has been criticized for its disappointing retention and the potential complications associated with underf…
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Cancer survival statistics in China 2019-2021: a multicenter, population-based study.
[BACKGROUND] A milestone goal of the Healthy China Program (2019-2030) is to achieve 5-year cancer survival at 43.3% for all cancers combined by 2022. To assess the progress towards this target, we analyzed the updated survival for all canc…
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Three-dimensional printing of facial contour based on preoperative computer simulation and its clinical application.
Facial contouring is a complex procedure performed to alter tissue contents and restore facial appearance. However, it is difficult to measure the amount of the tissue volume that is needed. This study demonstrated the use of preoperative c…