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The emergence of immune checkpoint inhibitors (ICIs) has transformed the treatment landscape of metastatic melanoma. However, despite its success, reliable biomarkers for predicting primary resistance are not available in clinical practice.…

Diffuse large B-cell Lymphoma (DLBCL) is the most prevalent subtype of non-Hodgkin's lymphoma for which current therapeutic strategies remain insufficient, in part owing to heterogeneity in tumor biology and the immune microenvironment. The…

[OBJECTIVES] To elucidate the mechanisms by which leukemia-derived exosomes induce immunosuppression in dendritic cells (DCs) and identify potential therapeutic targets. [METHODS] The optimal exosome dosage (20 µg/ml) for DC treatment was …

[ETHNOPHARMACOLOGICAL RELEVANCE] Helicobacter pylori (H. pylori) infection represents the most significant pathogenetic factor for chronic gastritis (CG) and is also the most critical controllable risk factor for the prevention of gastric c…

[BACKGROUND] The role of 5-methylcytosine (m5C) RNA modification in clear cell renal cell carcinoma (ccRCC) is recognized, yet its function and regulation on circular RNAs (circRNAs) remain uncharted. This study aims to identify key m5C reg…

Breast cancer's (BC) diverse nature and global impact demand tailored clinical strategies. Conventional screening methods often fall short in early detection and individualized risk assessment. By merging multi-omics technologies such as ge…

[ETHNOPHARMACOLOGICAL RELEVANCE] The efficacy of immunotherapy for hepatocellular carcinoma (HCC) is often limited by an immunosuppressive tumor microenvironment (TME), largely driven by tumor metabolic reprogramming (the Warburg effect) th…

Colorectal cancer (CRC) exhibits substantial heterogeneity in response to immunotherapy, highlighting the critical need for improved stratification strategies. Here, we established a robust multi-omics framework by integrating transcriptomi…

TL;DRA novel mechanistic insight is provided of SQYC's potential as a promising candidate for the clinical treatment of CRC through NQO1 suppression, ROS activation, and Wnt/β-catenin pathway inhibition.

TL;DRFindings establish thyroid function as a causal determinant of pancreatitis susceptibility, identify cell type-specific mechanisms including local thyroid hormone inactivation and metabolic reprogramming, and demonstrate…

[BACKGROUND] Prognostic biomarker panels identified through bulk sequencing approaches have shown utility in localized prostate cancer but are limited by underlying molecular heterogeneity. Spatial transcriptomics offers a complementary app…

TL;DRThis in silico study proposes a robust diagnostic gene signature for HCC and identifies tolrestat as a promising repurposing candidate that warrants experimental validation, demonstrating the utility of integrating machi…

To investigate the mechanisms of early brain metastasis in non-small cell lung cancer (NSCLC) using spatial multi-omics technology, develop predictive models, and identify potential therapeutic targets. A retrospective analysis was conducte…

[BACKGROUND] Compared to non-triple-negative breast cancer (Non-TNBC), triple-negative breast cancer (TNBC) exhibits significantly poorer prognosis. Previous research has confirmed that the PI3K/AKT pathway is closely associated with progno…

Breast cancer heterogeneity limits the precision of current prognostic and therapeutic strategies, underscoring the need for molecular frameworks that capture underlying metabolic drivers. Here, we systematically dissected the landscape of …

Spatial transcriptomics technologies such as Xenium, MERFISH, and Visium HD enable high-resolution profiling of gene expression while preserving tissue architecture. However, most computational methods for spatial analysis do not explicitly…

TL;DRHow decoding of epitranscriptomic signatures of malignancy can help transform the concept of tumor biology and provide with new avenues of diagnosis, prognosis, and targeted therapy options of breast and ovarian malignan…

TL;DRStromal FAP+ fibroblasts are unveiled as central regulators of macrophage-dependent immunosuppression via WNT2 signaling, proposing a novel therapeutic target to reprogram the TME in OSCC.

TL;DRThese results position ductular reactions as both a prognostic biomarker and therapeutic target, with cholic acid/NR1H4 pathway inhibition representing a promising immunotherapeutic strategy for hepatocellular carcinoma …

TL;DRThe cell type-dependent mechanism of BPNSs' selective killing is elucidates, providing insights into the potential application of BPNSs in targeted colorectal cancer therapy.