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Single-cell landscape of peripheral and tumor-infiltrating immune cells in HPV-negative HNSCC.
Head and neck squamous cell carcinoma (HNSCC) is the sixth most common cancer worldwide. HPV-negative HNSCC, arising in diverse upper airway mucosal niches, is particularly aggressive, with poor 5-y survival and a limited response to immune…
FULLTEXT: Transcriptomic sequencing -
Oncolytic virus OVV-03 enhances CAR-T cell therapy against glioblastoma via immune modulation and specific HER2 upregulation.
Glioblastoma (GBM) remains therapeutically challenging due to treatment resistance and immunosuppression. Oncolytic virotherapy offers a promising strategy. This study engineered OVV-03, a novel HER2-armed oncolytic vesicular stomatitis vir…
FULLTEXT: Transcriptomic sequencing -
Contrasting functions of CD73 and adenosine in CD8+ T-cell exhaustion during antitumor immunity.
T-cell exhaustion is a state of functional decline in T cells, driven by chronic antigen exposure and inhibitory signals within the tumor microenvironment. Exhausted CD8+ T cells (Tex) derive from precursor exhausted T cells (Tpex), a self-…
FULLTEXT: Transcriptomic sequencing -
Integrating tumor and immune cell transcriptomics to predict immune checkpoint inhibitor primary resistance in metastatic melanoma.
The emergence of immune checkpoint inhibitors (ICIs) has transformed the treatment landscape of metastatic melanoma. However, despite its success, reliable biomarkers for predicting primary resistance are not available in clinical practice.…
FULLTEXT: Transcriptomic sequencing -
XPO1 inhibitor selinexor suppresses homologous recombination by inhibiting E2F7 nuclear export in acute myeloid leukemia.
[OBJECTIVES] Aberrant nucleocytoplasmic transport mediated by Exportin 1 (XPO1) contributes to leukemogenesis, yet the molecular basis underlying the limited efficacy of the XPO1 inhibitor Selinexor in acute myeloid leukemia (AML) remains u…
FULLTEXT: Transcriptomic sequencing -
Exploring the key functions of T cells and the regulation of the immune microenvironment in prostate cancer using single-cell RNA sequencing and bulk RNA sequencing.
The incidence of prostate cancer continues to increase, making it the second most common malignant tumor among men worldwide. Immunotherapy has emerged as a key therapeutic strategy for treating tumors. Numerous studies have established tha…
FULLTEXT: Transcriptomic sequencing -
Novel bacterium sp. M3 promotes colorectal tumorigenesis via the production of the carcinogen styrene.
[BACKGROUND] The bacterial marker 'm3' shows promise for the non-invasive diagnosis of colorectal cancer (CRC) and adenomas. However, the m3-harboring bacterium (M3) had not been successfully cultured. [OBJECTIVE] This study aims to elucid…
FULLTEXT: Transcriptomic sequencing -
Monocytes acquire a tumor-associated IL1B program upon encountering patient-derived colon cancer organoids.
Tumor-associated macrophages (TAMs) and monocytes that accumulate in colorectal cancer (CRC) play a crucial role in shaping the tumor microenvironment (TME) and anti-tumor immune responses. Although TAMs have been linked to both pro- and an…
FULLTEXT: Transcriptomic sequencing -
TNF-α deficiency underlies NK cell dysfunction in colorectal cancer.
Natural killer (NK) cells are central to innate antitumor immunity, yet their function is systemically compromised in colorectal cancer (CRC). We show that CRC patients exhibit early and pronounced alterations in peripheral blood NK cells, …
FULLTEXT: Transcriptomic sequencing -
The distinct roles of and in proximal- and late-onset colorectal cancer.
Despite the emerging role of the gut microbiome in colorectal cancer (CRC), its significance in early-onset CRC (EOCRC, …
FULLTEXT: Transcriptomic sequencing -
Full-length 16S rRNA nanopore sequencing enables species resolution of associated with colorectal cancer.
Recent studies have revealed that the long-recognized link between the historically defined group and colorectal cancer is largely driven by . This species, along with two others ( and ), was recently reclassified as distinct from , highli…
FULLTEXT: Transcriptomic sequencing -
Gut microbiota-associated nutritional-immune status predicts prognosis in postoperative NSCLC patients.
[BACKGROUND] Surgical resection is the primary treatment for non-small cell lung cancer (NSCLC) patients with stages I and II; however, the postoperative prognosis varies among individuals. The prognostic nutritional index (PNI) reflects th…
FULLTEXT: Transcriptomic sequencing -
Multi-platform analysis of the tumor immune microenvironment associated with breast cancer subtypes.
Breast cancer is genetically and histologically heterogenous, and is influenced by a variety of factors, including the tumor microenvironment (TME). The PAM50 subtypes; Luminal A, Luminal B, Normal-like, Basal-like and Her2-enriched, are as…
FULLTEXT: Transcriptomic sequencing -
Early local immune activation following intra-operative radiotherapy in human breast tissue.
The local immune effects of cancer radiotherapy remain poorly characterized in humans due to limited access to irradiated tissue. Mechanistic insights largely derive from preclinical models employing tumor-intact, neoadjuvant-like settings.…
FULLTEXT: Transcriptomic sequencing -
Whole transcriptome sequencing reveals differences in the pathogenesis of myelodysplastic syndromes and acute myeloid leukemia.
[OBJECTIVES] Myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML) are closely related hematologic malignancies. However, the transcriptomic distinctions between them are not fully elucidated. This study aimed to identify transcri…
FULLTEXT: Transcriptomic sequencing -
Mutations in CHIP-associated genes at myeloid neoplasm diagnosis and risk of cardiovascular/cerebrovascular events.
[BACKGROUND] Clonal hematopoiesis of indeterminate potential (CHIP)-associated somatic mutations are associated with increased cardiovascular and cerebrovascular risk in the general population; whether mutations detected at myeloid neoplasm…
FULLTEXT: Transcriptomic sequencing -
The mouse gastric surface epithelial cell and its response to early infection.
infection is the main risk factor for gastric cancer. easily develop antibiotic resistance and evade host defenses. In-depth knowledge of the first barrier that encounter, the gastric surface mucus-producing epithelial cells (SMCs), may e…
FULLTEXT: Transcriptomic sequencing -
Ginkgolic acid targets HSPA8 to trigger ferroptosis in hepatocellular carcinoma chaperone-mediated autophagy-dependent GPX4 degradation.
[CONTEXT] Ginkgolic acid (GAC), one of the major active constituents of extract, has been reported as a potential anticancer agent. [OBJECTIVE] To investigate the effect of GAC on the viability of human hepatocellular carcinoma (HCC) cell…
FULLTEXT: Transcriptomic sequencing -
Targeting FMO3 suppresses the malignant phenotype of colorectal cancer: evidence from bioinformatics to functional experiments.
[AIMS] Flavin-containing monooxygenase 3 (FMO3) is a key metabolic enzyme involved in endogenous metabolism; however, its role in colorectal cancer (CRC) remains poorly understood. This study aimed to investigate the expression pattern, bio…
FULLTEXT: Transcriptomic sequencing -
Clinicopathological characteristics and therapeutic outcomes in patients with non-small cell lung cancer harboring mutations.
[OBJECTIVE] To investigate the clinical characteristics and impact of mutations in patients with non-small cell lung cancer (NSCLC). [METHODS] A total of 2,821 patients with NSCLC who underwent next-generation sequencing were retrospectiv…
FULLTEXT: Transcriptomic sequencing