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Advances in intravesical therapy for non-muscle-invasive bladder cancer.
Non-muscle-invasive bladder cancer (NMIBC) accounts for roughly 75% of newly diagnosed bladder cancer and associates with high risk of recurrence and progression. Intravesical therapy remains the cornerstone of NMIBC management following tr…
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Oncolytic virus OVV-03 enhances CAR-T cell therapy against glioblastoma via immune modulation and specific HER2 upregulation.
Glioblastoma (GBM) remains therapeutically challenging due to treatment resistance and immunosuppression. Oncolytic virotherapy offers a promising strategy. This study engineered OVV-03, a novel HER2-armed oncolytic vesicular stomatitis vir…
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Overcoming therapeutic challenges in acute myeloid leukemia: active targeting strategies by nano-drug delivery systems.
[BACKGROUND] Acute myeloid leukemia (AML) is a highly aggressive hematological malignancy characterized by poor overall survival and high relapse rates. The standard chemotherapy remains the conventional “7+3” regimens, while the suboptimal…
- Comparative efficacy and long-term survival of CD19/22 versus CD19 CAR-T immunotherapy in Relapsed/Refractory B-ALL with TP53 alterations.
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Survival improvements in major cancers: Trends and disparities in the United States, 2000-2019.
Advances in cancer management have improved oncologic outcomes, but the extent of these improvements and disparities across demographic and socioeconomic groups over the past two decades remains unclear. We identified patients diagnosed wit…
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Comparative efficacy and safety of acupuncture and moxibustion in the treatment of postprostatectomy urinary incontinence: A systematic review and network meta-analysis.
[BACKGROUND] To compare the efficacy and safety of different acupuncture and/or moxibustion methods in the treatment of postprostatectomy urinary incontinence using frequency-based network meta-analysis (NMA) method. [METHODS] Randomized c…
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Alterations in dynamic regional homogeneity and functional connectivity in lung cancer patients with bone metastasis pain.
[BACKGROUND] Although previous neuroimaging studies have characterized static brain activity in bone metastasis pain (BMP), its dynamic functional properties remain largely unexplored. This study aimed to investigate the dynamic brain activ…
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Long-term survival with PD-1/PD-L1 inhibitors plus platinum-based chemotherapy versus chemotherapy alone in locally advanced or metastatic pulmonary lymphoepithelioma-like carcinoma: updated follow-up analysis.
[PURPOSE] Pulmonary lymphoepithelioma-like carcinoma (PLELC), a rare Epstein-Barr virus (EBV)-associated non-small-cell lung cancer (NSCLC) subtype, exhibits distinct clinicopathological features but lacks evidence-based first-line therapy.…
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Examined lymph node counts ≤6 are correlated with an unfavorable prognosis in stage IA NSCLC patients following sublobar resection: a retrospective study employing propensity score matching analysis.
[BACKGROUND] Complete lymph node dissection improves staging accuracy in non-small cell lung cancer (NSCLC) patients and may improve outcomes in select patients. However, the benefit of increased lymph node examination in patients with stag…
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A preliminary study on the prognostic impact of platelet to monocyte ratio and its related genes on non-small cell lung cancer.
[PURPOSE] Impact of pre-treatment platelet-monocyte ratio on prognosis in patients with non-small cell lung cancer. 2. Screening and analyzing the relationship between NSCLC, platelet- and monocyte-associated genes and prognosis. 3. Express…
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A latent profile analysis of patient activation in postoperative breast cancer patients: a cross-sectional study.
[PURPOSE] To explore the level of patient activation (PA) and its subgroups among postoperative breast cancer patients, and to analyze the differences and influencing factors across these subgroups. [METHODS] A cross-sectional study was co…
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Identification of Potential Therapeutic Targets for Xihuang Pill in Breast Cancer: A Mendelian Randomization and Experimental Study.
[PURPOSE] Breast cancer remains a major threat to women's health worldwide, with drug resistance posing a significant challenge to treatment efficacy. Xihuang Pill (XHP), a traditional Chinese medicine formula, has demonstrated anti-tumor p…
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Investigating the mechanistic link between pesticide DDT and breast cancer through network toxicology, molecular docking, and molecular dynamics simulation.
To elucidate the molecular mechanisms by which the pesticide Dichlorodiphenyltrichloroethane (DDT) may contribute to breast cancer pathogenesis, focusing on its interactions with key cancer-related molecular pathways. Target genes of DDT an…
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Antioxidant regulatory mechanisms of retinoic acid and its therapeutic potential in oxidative stress-related diseases.
As a metabolite of vitamin A, retinoic acid (RA) is bound to nuclear receptors (RAR/RXR) to produce effects and regulate gene expression, showing antioxidant, anti-inflammatory, and anti-apoptotic activities [1]. Oxidative stress, induced b…
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Signal mining and analysis of influencing factors for adverse events of Nivolumab and Cetuximab in the treatment of head and neck cancer based on the US FAERS database.
[BACKGROUND] No prior research has directly compared adverse drug event (ADE) profiles of Nivolumab and Cetuximab in head and neck cancer (HNC) using the US FDA Adverse Event Reporting System (FAERS). The present study aims to evaluate ADE …
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Short-course-based TNT with or without PD-1 inhibitor for pMMR locally advanced rectal cancer: Phase 2 results of a randomized trial (STELLAR II).
[BACKGROUND] The therapeutic efficacy and mode of combining immunotherapy with neoadjuvant chemoradiotherapy in proficient mismatch repair (pMMR)/microsatellite stable (MSS) locally advanced rectal cancer (LARC) remain uncertain. [METHODS]…
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A Tumor Microenvironment-Responsive Self-Oxygenating Nanoplatform for Dual-Enhanced Cuproptosis and Sonodynamic Synergistic Immunotherapy.
Hypoxia in the tumor microenvironment (TME) severely compromises the effectiveness of sonodynamic therapy (SDT) and disrupts the process of cuproptosis. SDT generates insufficient reactive oxygen species (ROS) under low oxygen levels, while…
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Immune checkpoint inhibitors or targeted therapy by mismatch repair status in endometrial cancer: a meta-analysis.
[OBJECTIVE] This study evaluated the benefits of immune checkpoint inhibitors (ICIs) and/or targeted therapies in mismatch repair-deficient (dMMR) and mismatch repair-proficient (pMMR) patients with advanced or recurrent endometrial cancer …
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aPD-L1-facilitated theranostic and tumor microenvironment remodeling of pancreatic cancer via docetaxel-loaded phase-transformation nanoparticles triggered by low-intensity pulsed ultrasound.
Early diagnosis of pancreatic ductal adenocarcinoma (PDAC) is challenging because of its depth, which often leads to misdiagnosis during ultrasound examinations. The unique PDAC tumor microenvironment (TME) is characterized by significant f…
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Discovery of homocamptothecin derivative TOP-0618 as a radiosensitive agent for the treatment of pancreatic cancer.
[BACKGROUND] Pancreatic cancer is one of the most lethal malignancies characterized by a complex tumor microenvironment (TME) and highly heterogeneous nature, making it resistant to radiotherapy. This study aims to evaluate the radiosensiti…
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Evaluating the Impact of Oral Contraceptives on Pancreatic Cancer Risk: A Two-Sample Mendelian Randomization Analysis.
The relationship between oral contraceptive (OC) use and pancreatic cancer (PC) risk remains controversial, with inconsistent findings reported in observational studies. To clarify this relationship and better identify potential risk factor…
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Development and validation of a nomogram to predict failure of initial radioactive iodine therapy in differentiated thyroid cancer: a retrospective cohort study.
Given the scarcity of studies predicting iodine-131 treatment failure based on clinicopathological factors, this study aimed to determine whether clinicopathological features can predict iodine-131 treatment failure in differentiated thyroi…
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mRNA vaccines for prostate cancer: A novel promising immunotherapy.
The treatment of advanced prostate cancer (PCa) primarily based on androgen deprivation therapy (ADT); however, patients inevitably progress to the castration-resistant prostate cancer (CRPC) stage. Despite the recent advancements in CRPC t…
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SREBF1-mediated SND1 transcriptional activation promotes prostate cancer progression via MTDH interaction through the SESN2/AMPK/mTOR axis.
[BACKGROUND] Prostate cancer (PCa) is a prevalent cancer and a major cause of cancer-related deaths in men worldwide. Growing evidence indicates that Staphylococcal nuclease and Tudor domain containing 1 (SND1) is a multifunctional protein …
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Survival improvements and disparities in metastatic prostate adenocarcinoma, clear cell renal cell carcinoma, and urothelial carcinoma of bladder.
Over the past two decades, treatment advancements have significantly changed the management of metastatic prostate cancer (PCa), clear cell renal cell carcinoma (ccRCC), and urothelial carcinoma of the bladder (UCB), but it remains unclear …
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small cell neuroendocrine carcinoma of the prostate with extremely elevated PSA and Gleason score 5 + 5: a case report.
[OBJECTIVES] The aims of this study were to report an exceptionally rare case of small cell neuroendocrine carcinoma of the prostate (SCNEPC) presenting with unprecedented prostate-specific antigen (PSA) elevation and Gleason score 5 + 5, …
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Impaired ARID1A expression attenuated the immune response in gastric cancer via histone acetylation.
[BACKGROUND] The primary objective of this study was to examine whether ARID1A mutations confer a fitness advantage to gastric cancer from an immunological perspective, along with elucidating the underlying mechanism. Additionally, we aimed…
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Oncogene OSTM1 Promotes Gastric-Cancer Metastasis by Modulating the Metastatic Microenvironment Through Altered Tumor-Cell Autocrine Signaling.
Gastric cancer remains a malignancy with high incidence, mortality rates, and poor prognosis globally. Osteoclastogenesis-associated transmembrane protein 1 (OSTM1), a transmembrane protein overexpressed in various tumors, has unclear funct…
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The EGR1-mediated lncRNA TENM3-AS1 potentiates gastric cancer metastasis via reprogramming fatty acid metabolism.
[BACKGROUND] Long non-coding RNAs (lncRNAs) are essential modulators in tumor progression. While fatty acid (FA) metabolism can potentiate tumorigenesis, colonization, and metastasis, the roles of lncRNAs in reprograming FA metabolism and r…
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Neutrophil membrane engineered human umbilical cord MSC-derived sEVs enhance anti-tumor efficacy for gastric cancer via delivering pentraxin 3.
Gastric cancer poses a significant global health challenge, promoting ongoing updates and exploration of treatment strategies. In this study, we proposed the naïve human umbilical cord mesenchymal stem cell derived small extracellular vesic…