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Single-cell landscape of peripheral and tumor-infiltrating immune cells in HPV-negative HNSCC.
Head and neck squamous cell carcinoma (HNSCC) is the sixth most common cancer worldwide. HPV-negative HNSCC, arising in diverse upper airway mucosal niches, is particularly aggressive, with poor 5-y survival and a limited response to immune…
FULLTEXT: Transcriptome sequencing -
Oncolytic virus OVV-03 enhances CAR-T cell therapy against glioblastoma via immune modulation and specific HER2 upregulation.
Glioblastoma (GBM) remains therapeutically challenging due to treatment resistance and immunosuppression. Oncolytic virotherapy offers a promising strategy. This study engineered OVV-03, a novel HER2-armed oncolytic vesicular stomatitis vir…
FULLTEXT: Transcriptome sequencing -
Integrating tumor and immune cell transcriptomics to predict immune checkpoint inhibitor primary resistance in metastatic melanoma.
The emergence of immune checkpoint inhibitors (ICIs) has transformed the treatment landscape of metastatic melanoma. However, despite its success, reliable biomarkers for predicting primary resistance are not available in clinical practice.…
FULLTEXT: Transcriptome sequencing -
Exploring the key functions of T cells and the regulation of the immune microenvironment in prostate cancer using single-cell RNA sequencing and bulk RNA sequencing.
The incidence of prostate cancer continues to increase, making it the second most common malignant tumor among men worldwide. Immunotherapy has emerged as a key therapeutic strategy for treating tumors. Numerous studies have established tha…
FULLTEXT: Transcriptome sequencing -
Novel bacterium sp. M3 promotes colorectal tumorigenesis via the production of the carcinogen styrene.
[BACKGROUND] The bacterial marker 'm3' shows promise for the non-invasive diagnosis of colorectal cancer (CRC) and adenomas. However, the m3-harboring bacterium (M3) had not been successfully cultured. [OBJECTIVE] This study aims to elucid…
FULLTEXT: Transcriptome sequencing -
Monocytes acquire a tumor-associated IL1B program upon encountering patient-derived colon cancer organoids.
Tumor-associated macrophages (TAMs) and monocytes that accumulate in colorectal cancer (CRC) play a crucial role in shaping the tumor microenvironment (TME) and anti-tumor immune responses. Although TAMs have been linked to both pro- and an…
FULLTEXT: Transcriptome sequencing -
The distinct roles of and in proximal- and late-onset colorectal cancer.
Despite the emerging role of the gut microbiome in colorectal cancer (CRC), its significance in early-onset CRC (EOCRC, …
FULLTEXT: Transcriptome sequencing -
Full-length 16S rRNA nanopore sequencing enables species resolution of associated with colorectal cancer.
Recent studies have revealed that the long-recognized link between the historically defined group and colorectal cancer is largely driven by . This species, along with two others ( and ), was recently reclassified as distinct from , highli…
FULLTEXT: Transcriptome sequencing -
Gut microbiota-associated nutritional-immune status predicts prognosis in postoperative NSCLC patients.
[BACKGROUND] Surgical resection is the primary treatment for non-small cell lung cancer (NSCLC) patients with stages I and II; however, the postoperative prognosis varies among individuals. The prognostic nutritional index (PNI) reflects th…
FULLTEXT: Transcriptome sequencing -
Multi-platform analysis of the tumor immune microenvironment associated with breast cancer subtypes.
Breast cancer is genetically and histologically heterogenous, and is influenced by a variety of factors, including the tumor microenvironment (TME). The PAM50 subtypes; Luminal A, Luminal B, Normal-like, Basal-like and Her2-enriched, are as…
FULLTEXT: Transcriptome sequencing -
Early local immune activation following intra-operative radiotherapy in human breast tissue.
The local immune effects of cancer radiotherapy remain poorly characterized in humans due to limited access to irradiated tissue. Mechanistic insights largely derive from preclinical models employing tumor-intact, neoadjuvant-like settings.…
FULLTEXT: Transcriptome sequencing -
Whole transcriptome sequencing reveals differences in the pathogenesis of myelodysplastic syndromes and acute myeloid leukemia.
[OBJECTIVES] Myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML) are closely related hematologic malignancies. However, the transcriptomic distinctions between them are not fully elucidated. This study aimed to identify transcri…
FULLTEXT: Transcriptome sequencing -
Mutations in CHIP-associated genes at myeloid neoplasm diagnosis and risk of cardiovascular/cerebrovascular events.
[BACKGROUND] Clonal hematopoiesis of indeterminate potential (CHIP)-associated somatic mutations are associated with increased cardiovascular and cerebrovascular risk in the general population; whether mutations detected at myeloid neoplasm…
FULLTEXT: Transcriptome sequencing -
The mouse gastric surface epithelial cell and its response to early infection.
infection is the main risk factor for gastric cancer. easily develop antibiotic resistance and evade host defenses. In-depth knowledge of the first barrier that encounter, the gastric surface mucus-producing epithelial cells (SMCs), may e…
FULLTEXT: Transcriptome sequencing -
Ginkgolic acid targets HSPA8 to trigger ferroptosis in hepatocellular carcinoma chaperone-mediated autophagy-dependent GPX4 degradation.
[CONTEXT] Ginkgolic acid (GAC), one of the major active constituents of extract, has been reported as a potential anticancer agent. [OBJECTIVE] To investigate the effect of GAC on the viability of human hepatocellular carcinoma (HCC) cell…
FULLTEXT: Transcriptome sequencing -
Clinicopathological characteristics and therapeutic outcomes in patients with non-small cell lung cancer harboring mutations.
[OBJECTIVE] To investigate the clinical characteristics and impact of mutations in patients with non-small cell lung cancer (NSCLC). [METHODS] A total of 2,821 patients with NSCLC who underwent next-generation sequencing were retrospectiv…
FULLTEXT: Transcriptome sequencing -
Single-cell RNA sequencing analysis of bone cancer pain model induced by Lewis lung cancer cells in male mice.
[BACKGROUND] Bone cancer pain (BCP) is one of the most severe complications faced by cancer patients, with complex physiological and pathological mechanisms and unclear molecular characteristics. [METHODS] The BCP model was established by …
FULLTEXT: Transcriptome sequencing -
Surgical management of concomitant lung cancer and cardiovascular diseases: a multidisciplinary perspective.
Lung cancer and cardiovascular diseases (CVDs) frequently coexist due to shared risk factors such as aging, smoking, and chronic inflammation. The growing prevalence of elderly surgical candidates with concomitant lung cancer and CVDs prese…
FULLTEXT: Transcriptome sequencing -
Costs and benefits of whole-exome, whole-transcriptome sequencing versus 50-gene panels for genomic profiling in solid tumors.
[AIMS] The rapid development of therapies linked to molecular biomarkers has increased the importance of next-generation sequencing (NGS)-based tumor profiling to guide treatment decisions. Technology has enabled more comprehensive clinical…
FULLTEXT: Transcriptome sequencing -
Immunotherapy for virus-related hepatocellular carcinoma: recent progress and future directions.
[BACKGROUND] Hepatocellular carcinoma (HCC) is a leading cause of cancer-related mortality worldwide, with hepatitis B virus (HBV) and hepatitis C virus (HCV) infections remaining the predominant etiological factors. Chronic viral infection…
FULLTEXT: Transcriptome sequencing