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Single-cell landscape of peripheral and tumor-infiltrating immune cells in HPV-negative HNSCC.
Head and neck squamous cell carcinoma (HNSCC) is the sixth most common cancer worldwide. HPV-negative HNSCC, arising in diverse upper airway mucosal niches, is particularly aggressive, with poor 5-y survival and a limited response to immune…
FULLTEXT: Transcriptome sequencing randomized -
Oncolytic virus OVV-03 enhances CAR-T cell therapy against glioblastoma via immune modulation and specific HER2 upregulation.
Glioblastoma (GBM) remains therapeutically challenging due to treatment resistance and immunosuppression. Oncolytic virotherapy offers a promising strategy. This study engineered OVV-03, a novel HER2-armed oncolytic vesicular stomatitis vir…
FULLTEXT: Transcriptome sequencing randomized -
Integrating tumor and immune cell transcriptomics to predict immune checkpoint inhibitor primary resistance in metastatic melanoma.
The emergence of immune checkpoint inhibitors (ICIs) has transformed the treatment landscape of metastatic melanoma. However, despite its success, reliable biomarkers for predicting primary resistance are not available in clinical practice.…
FULLTEXT: Transcriptome sequencing randomized -
Exploring the key functions of T cells and the regulation of the immune microenvironment in prostate cancer using single-cell RNA sequencing and bulk RNA sequencing.
The incidence of prostate cancer continues to increase, making it the second most common malignant tumor among men worldwide. Immunotherapy has emerged as a key therapeutic strategy for treating tumors. Numerous studies have established tha…
FULLTEXT: Transcriptome sequencing randomized -
Novel bacterium sp. M3 promotes colorectal tumorigenesis via the production of the carcinogen styrene.
[BACKGROUND] The bacterial marker 'm3' shows promise for the non-invasive diagnosis of colorectal cancer (CRC) and adenomas. However, the m3-harboring bacterium (M3) had not been successfully cultured. [OBJECTIVE] This study aims to elucid…
FULLTEXT: Transcriptome sequencing randomized -
Monocytes acquire a tumor-associated IL1B program upon encountering patient-derived colon cancer organoids.
Tumor-associated macrophages (TAMs) and monocytes that accumulate in colorectal cancer (CRC) play a crucial role in shaping the tumor microenvironment (TME) and anti-tumor immune responses. Although TAMs have been linked to both pro- and an…
FULLTEXT: Transcriptome sequencing randomized -
The distinct roles of and in proximal- and late-onset colorectal cancer.
Despite the emerging role of the gut microbiome in colorectal cancer (CRC), its significance in early-onset CRC (EOCRC, …
FULLTEXT: Transcriptome sequencing randomized -
Full-length 16S rRNA nanopore sequencing enables species resolution of associated with colorectal cancer.
Recent studies have revealed that the long-recognized link between the historically defined group and colorectal cancer is largely driven by . This species, along with two others ( and ), was recently reclassified as distinct from , highli…
FULLTEXT: Transcriptome sequencing randomized -
Gut microbiota-associated nutritional-immune status predicts prognosis in postoperative NSCLC patients.
[BACKGROUND] Surgical resection is the primary treatment for non-small cell lung cancer (NSCLC) patients with stages I and II; however, the postoperative prognosis varies among individuals. The prognostic nutritional index (PNI) reflects th…
FULLTEXT: Transcriptome sequencing randomized -
Multi-platform analysis of the tumor immune microenvironment associated with breast cancer subtypes.
Breast cancer is genetically and histologically heterogenous, and is influenced by a variety of factors, including the tumor microenvironment (TME). The PAM50 subtypes; Luminal A, Luminal B, Normal-like, Basal-like and Her2-enriched, are as…
FULLTEXT: Transcriptome sequencing randomized -
Early local immune activation following intra-operative radiotherapy in human breast tissue.
The local immune effects of cancer radiotherapy remain poorly characterized in humans due to limited access to irradiated tissue. Mechanistic insights largely derive from preclinical models employing tumor-intact, neoadjuvant-like settings.…
FULLTEXT: Transcriptome sequencing randomized -
Prolonged progression-free survival with zanubrutinib in relapsed/refractory CLL: an indirect treatment comparison versus other BTK inhibitors using multilevel network meta-regression.
[BACKGROUND] Bruton tyrosine kinase inhibitors (BTKis) are therapeutic agents for relapsed/refractory chronic lymphocytic leukemia (R/R CLL). Previous indirect treatment comparisons are limited in simultaneously comparing multiple intervent…
FULLTEXT: Transcriptome sequencing randomized -
The surgery for the patients with intestinal non‑Hodgkin lymphomas: a nationwide study.
[BACKGROUND] The treatment strategy for intestinal non-Hodgkin lymphoma (NHL) and the role of surgery warrant reevaluation. [METHODS] This study analyzed clinical data from a cohort of 12,047 patients diagnosed with intestinal NHL, extract…
FULLTEXT: Transcriptome sequencing randomized -
Whole transcriptome sequencing reveals differences in the pathogenesis of myelodysplastic syndromes and acute myeloid leukemia.
[OBJECTIVES] Myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML) are closely related hematologic malignancies. However, the transcriptomic distinctions between them are not fully elucidated. This study aimed to identify transcri…
FULLTEXT: Transcriptome sequencing randomized -
Mutations in CHIP-associated genes at myeloid neoplasm diagnosis and risk of cardiovascular/cerebrovascular events.
[BACKGROUND] Clonal hematopoiesis of indeterminate potential (CHIP)-associated somatic mutations are associated with increased cardiovascular and cerebrovascular risk in the general population; whether mutations detected at myeloid neoplasm…
FULLTEXT: Transcriptome sequencing randomized -
A Randomized Trial Evaluating Intraoperative Ischemic Preconditioning of Parathyroid Glands During Total Thyroidectomy: A Signal for Earlier Parathyroid Function Recovery.
[BACKGROUND] Ischemic preconditioning of parathyroid glands (IPCP) is biologically plausible but clinical evidence is limited. In this single-center randomized trial (ChiCTR2000039788), we compared IPCP versus control during total thyroidec…
FULLTEXT: Transcriptome sequencing randomized -
Comparison of the effects of exercise-based interventions on cardiometabolic health and fatigue in men with prostate cancer receiving androgen deprivation therapy: A network meta-analysis.
[OBJECTIVE] To compare the effects of exercise-based interventions on cardiometabolic health and fatigue in men with prostate cancer receiving androgen deprivation therapy (ADT). [METHODS] A comprehensive search for Randomized controlled s…
FULLTEXT: Transcriptome sequencing randomized -
The mouse gastric surface epithelial cell and its response to early infection.
infection is the main risk factor for gastric cancer. easily develop antibiotic resistance and evade host defenses. In-depth knowledge of the first barrier that encounter, the gastric surface mucus-producing epithelial cells (SMCs), may e…
FULLTEXT: Transcriptome sequencing randomized -
Ginkgolic acid targets HSPA8 to trigger ferroptosis in hepatocellular carcinoma chaperone-mediated autophagy-dependent GPX4 degradation.
[CONTEXT] Ginkgolic acid (GAC), one of the major active constituents of extract, has been reported as a potential anticancer agent. [OBJECTIVE] To investigate the effect of GAC on the viability of human hepatocellular carcinoma (HCC) cell…
FULLTEXT: Transcriptome sequencing randomized -
Impact of offering blood-based testing alongside existing modalities for colorectal cancer screening among those who previously declined screening: an economic evaluation.
[AIM] Inadequate adherence to colorectal cancer screening reduces individual and population level health benefits. Blood-based tests offer a new modality that may help patients overcome barriers, but there are concerns about the impact of p…
FULLTEXT: Transcriptome sequencing randomized