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Sex determines the natural killer cell-mediated immunity against pancreatic cancer.
Pancreatic ductal adenocarcinoma (PDAC) ranks among the most aggressive malignancies and exhibits a higher prevalence and poorer prognosis in male patients. While both the importance of natural killer (NK) cells in anti-tumor immunity and s…
FULLTEXT: Structural optimization -
Capacity to care: Provider agency and socio-structural constraints in breast cancer care across public secondary and tertiary hospitals in Soweto.
Timely breast cancer care remains challenging in South Africa, where both health-system and patient-level barriers contribute to delayed diagnosis and treatment. This study explored healthcare providers' experiences and perspectives on brea…
FULLTEXT: Structural optimization -
Trial Watch - bispecific T cell engagers and higher-order multispecific immunotherapeutics.
Over the past decades, cancer immunotherapy has evolved into clinical practice, with bispecific T cell engagers (TCEs) and other higher-order multispecific immunotherapeutics emerging as approaches for precision immune modulation. These eng…
FULLTEXT: Structural optimization -
Microbiota as a modulator of drug response: targeting microbial-drug crosstalk in cancer therapy.
In recent years, accumulating evidence has established mechanistic connections between the microbiota and the efficacy of anticancer treatments, encompassing microbial communities residing in the gut, within tumors, and across other tissue …
FULLTEXT: Structural optimization -
Advances in natural killer cell immunotherapy for hematologic malignancies.
Natural killer (NK) cells are a unique subset of cytotoxic lymphocytes within the innate immune system. They play a pivotal role in antiviral and antitumor immunity. NK cell-based adoptive immunotherapy has advanced rapidly in recent years.…
FULLTEXT: Structural optimization -
Pre-ablation stimulated thyroglobulin to TSH ratio as a strong predictor of non-generally satisfactory response to initial radioiodine therapy in papillary thyroid carcinoma patients undergoing lateral neck dissection.
[BACKGROUND] The initial response to radioiodine (³I) therapy is a critical determinant of prognosis in papillary thyroid carcinoma (PTC) patients undergoing therapeutic lateral neck dissection (LND). This study aimed to identify predictors…
FULLTEXT: Structural optimization -
Association between postoperative urinary incontinence severity and anxiety in patients with prostate cancer: A chain mediation analysis of ehealth literacy and pelvic floor muscle training adherence.
[OBJECTIVE] This study aimed to examine the chain mediating roles of eHealth literacy and pelvic floor muscle training (PFMT) adherence in the association between urinary incontinence (UI) severity and anxiety. [METHODS] A cross-sectional …
FULLTEXT: Structural optimization -
Identification and biological evaluation of benzimidazole-based compounds as novel TGFβR1 inhibitors.
TGF-β promotes progression and metastasis in later stages of tumour development, and inhibitors targeting TGF-β or its receptor have faced clinical limitations due to toxicity and poor selectivity. This study aimed to identify novel TGFβR1 …
FULLTEXT: Structural optimization -
DA-LUNGNET: a multi-stage deep framework with adaptive attention for early detection of subcentimeter pulmonary nodules.
Early and reliable detection of subcentimeter pulmonary nodules remains a major bottleneck in low-dose CT-based lung cancer screening due to high miss rates, vascular-adhesion-induced false positives, and insufficient multi-scale feature fu…
FULLTEXT: Structural optimization -
Discovery of novel and highly potent XIAP-targeted peptide inhibitors using virtual screening.
Lung cancer, a globally prevalent fatal malignancy, remains a major therapeutic challenge. X-linked inhibitor of apoptosis protein (XIAP) is overexpressed in various cancers, driving uncontrolled proliferation, while its specific inhibition…
FULLTEXT: Structural optimization -
A tri-scale in silico framework integrating pharmacovigilance and mechanistic modeling suggests tepotinib-associated acute kidney injury risk.
Proactive safety evaluation of molecularly targeted therapies requires generalizable frameworks that integrate real-world evidence with mechanistic insights. As a case in point, tepotinib, a mesenchymal-epithelial transition (MET) inhibitor…
FULLTEXT: Structural optimization -
Advancing the understanding of the immune escape in lung cancer immunotherapy: Global trends, collaborations, and future directions.
Immune escape mechanisms critically restrict the efficacy of immunotherapy in lung cancer (LC), with only 20%-30% of patients responding to checkpoint inhibitors. To systematically map global trends and identify emerging hotspots, this stud…
FULLTEXT: Structural optimization -
Optimizing immunotherapy for head and neck squamous cell carcinoma: recent advances and future directions.
[BACKGROUND] Head and neck squamous cell carcinoma (HNSCC) is the sixth most prevalent malignancy globally. Despite advancements in surgery, chemotherapy, and radiotherapy, the recurrence rate in advanced-stage HNSCC remains high, with a 5-…
FULLTEXT: Structural optimization -
The making of multispecific immunoglobulins - a clinical perspective.
Over the past two decades, bi- and multispecific antibodies have emerged as a rapidly advancing class of therapeutic biologics, transforming oncology and immunotherapy. By simultaneously binding two or more distinct antigens or epitopes, th…
FULLTEXT: Structural optimization -
A system-level metastable model of cancer evolution: integrating replication stress, cell cycle deregulation and chromosomal instability.
[INTRODUCTION] Cancer cell proliferation occurs within the context of persistent genomic instability. In this review, we propose the RS-CCD-CIN axis as a systems-level framework in which replication stress (RS), cell cycle deregulation (CCD…
FULLTEXT: Structural optimization -
Condensin complexes: from chromatin organization to disease.
Condensin complexes are indispensable for mitotic chromosome condensation. In this review, we summarize their structural and functional features, focusing on ATP-dependent loop extrusion and mitotic chromatin folding. We discuss current mod…
FULLTEXT: Structural optimization -
Preclinical advances and mechanistic insights of CAR-T therapy for acute myeloid leukemia: from target iteration to microenvironment regulation.
[INTRODUCTION] Relapsed/refractory acute myeloid leukaemia (AML) carries a dismal prognosis, primarily due to profound biological heterogeneity and the scarcity of effective targeted therapies. Chimeric antigen receptor T (CAR-T) cell thera…
FULLTEXT: Structural optimization -
LDH isozymes as targets for cancer therapy.
The Warburg effect, a hallmark of cancer, positions lactate dehydrogenase (LDH) as a key therapeutic target. Mammals possess three LDH isozymes (LDH-A, LDH-B, LDH-C) with distinct properties. This review critically re-evaluates the simplist…
FULLTEXT: Structural optimization -
Research progress on the molecular mechanisms of PD-1 and LAG-3 synergy in regulating T cell exhaustion and immunotherapy.
[BACKGROUND] PD-1 and LAG-3 are immune checkpoint molecules frequently co-expressed in the tumor microenvironment, where they synergistically drive T-cell exhaustion and immune escape. Dual blockade of these pathways represents a promising …
FULLTEXT: Structural optimization -
Oncolytic virus therapy for hepatocellular carcinoma: A bibliometric analysis of research landscapes, hotspots, and clinical transformation trends from 2000 to mid-2025.
This study aimed to systematically analyze the research status, hotspots, and trends of oncolytic virotherapy (OV) for hepatocellular carcinoma (HCC) from 2000 to mid-2025, scientifically predict future directions, facilitate clinical trans…
FULLTEXT: Structural optimization