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Diagnostic Challenges in Identifying Concurrent Myeloid Sarcoma and High-Grade Prostatic Adenocarcinoma Within the Prostate.
Myeloid sarcoma is an extramedullary mass lesion composed of myeloid blasts that disrupt tissue architecture. Myeloid sarcoma in the prostate is exceptionally rare, with fewer than 30 patients reported. Among these, 8 have been observed wit…
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Diagnostic Pitfalls of -Rearranged Perivascular Epithelioid Cell Tumor of the Kidney.
-rearranged perivascular epithelioid cell tumors (PEComas) of the kidney are rare, with fewer than 50 examples reported in the literature. A 32-year-old man presented with an 8.2 cm right renal mass and bulky retroperitoneal lymphadenopathy…
- Retraction notice to "Roles of long non-coding RNA in prostate cancer pathogenesis" [Clinical Genitourinary Cancer 22 (2024) 102213].
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Ultrasound and ROS-responsive nanodroplets inhibit TCA cycle in hepatocellular carcinoma.
Abnormal energy metabolism patterns are common characteristics of various tumor cells, including hepatocellular carcinoma cells (HCC). HCC undergo metabolic reprogramming, upregulating the tricarboxylic acid (TCA) cycle and mitochondrial re…
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Prognostic impact of sarcopenia on 5-year overall and progression-free survival in lung cancer patients: a prospective cohort study.
[BACKGROUND] Sarcopenia is increasingly recognized as a critical prognostic factor in cancer patients, particularly in lung cancer, However, currently the relationship between Sarcopenia and lung cancer prognosis was primarily assessed usin…
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Male invasive breast carcinoma containing both mucinous and micropapillary components with axillary lymph node metastasis: a rare case report with literature review.
[BACKGROUND] Male breast cancer (MBC) accounts for less than 1% of all breast cancer cases. Due to societal cognitive biases, males' neglect of breast health, and associated stigma, diagnosis is often delayed, leading to disease progression…
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One-Stone-Two-Birds Carrier-Free Nano-Cocktail Enables Synergistic Eradication of Cancer Cells/Stem Cells in Breast Cancer Treatment.
Cancer stem cells (CSCs) are widely recognized as the culprits of chemoresistance, tumor metastasis, and relapse. Moreover, most chemotherapeutic drugs not only fail to eliminate CSCs effectively, but also induce the acquisition of stemness…
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Chrysophanol attenuates breast cancer angiogenesis through blocking VEGFA/VEGFR2/ERK activation via inhibiting ACE2 ubiquitination.
[BACKGROUND] Breast cancer progression depends on abnormal angiogenesis, driven by VEGF/VEGFR2/ERK and inhibited by Angiotensin-Converting Enzyme 2 (ACE2). Chrysophanol (CHR) shows anti-breast cancer efficacy, but its mechanism is unclear. …
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Microbiota as a modulator of drug response: targeting microbial-drug crosstalk in cancer therapy.
In recent years, accumulating evidence has established mechanistic connections between the microbiota and the efficacy of anticancer treatments, encompassing microbial communities residing in the gut, within tumors, and across other tissue …
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Rg3 inhibits hypoxia-induced tumor exosomes from boosting pancreatic cancer vasculogenic mimicry through the HIF-1α/LARS1/mTOR axis.
[BACKGROUND] Pancreatic cancer (PC), characterized by a poor prognosis, can utilize hypoxia to activate vasculogenic mimicry (VM) and facilitate metastasis. Exosomes serve as crucial mediators in this hypoxic environment. Our previous studi…
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N6-methyladenosine-modified circQKI inhibits prostate cancer docetaxel-sensitivity via miR-188-3p/Beclin-1 pathway.
[BACKGROUND] Docetaxel (DTX) is used in the first-line chemotherapy for advanced castration-resistant prostate cancer (CRPC), but resistance remains a major clinical challenge. Circular RNAs (circRNAs) play critical roles in DTX resistance.…
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Diagnostic Value of Artificial Intelligence-Based Pathology Diagnosis System in Lymphatic Metastasis of Gastric Cancer.
[INTRODUCTION] Gastric cancer (GC) remains one of the leading causes of cancer-related mortality worldwide, with lymph node metastasis (LNM) being an independent prognostic factor. However, there are still challenges in the pathological dia…
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Raddeanoside R13 Inhibits Proliferation, Invasion, and Metastasis of Gastric Cancer Cells Based on Network Pharmacology and Experimental Validation.
[OBJECTIVE] This study aims to explore the potential mechanisms by which Rad-deanoside R13 (R13) inhibits the proliferation, invasion, and metastasis of gastric cancer (GC) cells through network pharmacology analysis and experimental valida…
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Bidirectional Mendelian randomization analysis and systematic meta-analysis of causal relationships between hepatocellular carcinoma and non-alcoholic fatty liver disease.
[BACKGROUND] The causal relationships between hepatocellular carcinoma (HCC) and non-alcoholic fatty liver disease (NAFLD) remain unclear. This study investigated bidirectional causality between HCC and NAFLD using Mendelian randomization, …
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A label-free electrochemical biosensor based on a bimetallic organic framework for the detection of carbohydrate antigen 19-9.
Carbohydrate antigen 19-9 (CA19-9) is an important marker for pancreatic cancer, ovarian cancer and other tumors, and its rapid and stable detection is the basis for early diagnosis and treatment. In this paper, a label-free electrochemical…
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Comparison of Various Ultrasound-Based Malignant Risk Stratification Systems on an Occasion for Assessing Thyroid Nodules in Hashimoto's Thyroiditis.
[PURPOSE] To compare the diagnostic performance and unnecessary ultrasound-guided fine-needle aspiration (US-FNA) biopsy rate of the 2015 American Thyroid Association (ATA), 2016 Korean Society of Thyroid Radiology (KSThR), and 2017 America…