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Prostate Cancer Care for Men with an Intellectual Disability: A Population-based Cohort Study of Symptoms, Diagnosis, Treatment, and Survival.
[BACKGROUND AND OBJECTIVE] Intellectual disability (ID) is increasingly recognised as a hidden driver of cancer mortality. However, evidence on prostate cancer (PC) care in this population is limited. [METHODS] The study population compris…
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Downregulation of the lncRNA PGM5P4-AS1 predicts poor prognosis and drives breast cancer progression through miR-3664-5p/KLF9.
[BACKGROUND] Accumulating evidence suggests that deregulated long non-coding RNAs (lncRNAs) drive breast cancer (BRCA) progression. This study investigated the expression profile and mechanism of PGM5P4 antisense RNA 1 (PGM5P4-AS1) in BRCA.…
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Assessment of risk factors of breast cancer among women in Dodoma, Tanzania: a community-based cross-sectional study.
Assessment of risk factors of breast cancer in the general population provides insightful information towards prevention of breast cancer. This study aimed to assess the risk factors of breast cancer among women in a community from a resour…
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Goosecoid facilitates the metastasis of pancreatic adenocarcinoma by enhancing EMT and stemness via regulating TGF-β/SMAD2/3 signaling.
Pancreatic adenocarcinoma (PAAD) is a highly aggressive malignant tumor of the gastrointestinal tract. Goosecoid (GSC), translated from a homeobox gene, is a protein participating in metastasis of assorted tumors. This study explores the ro…
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Dynamic changes in cellular mechanics and membrane microviscosity during migration of colorectal cancer cells.
The ability of tumor cells to migrate and invade adjacent tissue is a key property underlying the metastatic process. To ensure greater deformability and to facilitate movement, migratory cells undergo multiple changes in biophysical parame…
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Factors associated with the recurrence of intermittent exotropia and reoperations in the long term.
[PURPOSE] To evaluate long-term reoperation risk after bilateral lateral rectus (BLR) recession for intermittent exotropia (IXT) in a paediatric cohort, and to identify the perioperative factors associated with recurrence and reoperation. …
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Neural network reveals platelet age from fluorescence microscopy images.
Platelets are small, anucleate cells with a primary physiological role in vascular damage repair (hemostasis) and initiation of thrombus formation in response to vascular injury. Platelets circulate approximately 7-10 days, slowly undergoin…
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Diagnostic performance and generalizability of a clinical-ultrasound radiomics model for predicting extrathyroidal extension in thyroid carcinoma: a retrospective study.
[BACKGROUND] Ultrasound plays a crucial role in the preoperative evaluation of thyroid carcinoma and its extrathyroidal extension (ETE). This study aims to develop and validate a model integrating ultrasound radiomics and clinical factors f…
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Dyadic coping, relationship quality, and psychosocial adaption between couples facing prostate cancer: A longitudinal cross-lagged study.
[OBJECTIVE] To explore the associations among dyadic coping, close relationship, and psychosocial adaption in prostate cancer couples during the first six months after diagnosis. [METHODS] Newly diagnosed prostate cancer patients and their…
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Development and validation of a predictive model for high-risk immune-related adverse events in gastric cancer patients treated with ICIs.
Immune checkpoint inhibitors (ICIs) may cause immune-related adverse events (irAEs), ranging from mild to life-threatening. High-risk irAEs can lead to treatment discontinuation and higher mortality, though ICI-treated patients' death rate …
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Psychological distress and its determinants among spouses of patients with familial clustering of hepatitis B virus-related hepatocellular carcinoma: A cross-sectional study.
[OBJECTIVE] To explore psychological distress and its influencing factors, including hope, rumination, and fear of disease progression, among spouses of patients diagnosed with familial clustering of hepatitis B virus (HBV) -related hepatoc…
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Model-based evaluation of colorectal cancer screening effectiveness: three rounds of multitarget stool DNA testing versus one colonoscopy.
[BACKGROUND] Several colorectal cancer (CRC) screening modalities are guideline-recommended in the United States but differ in screening interval and real-world adherence. Accordingly, single-round test performance may not reflect cumulativ…
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A vision-language model-based approach for lung cancer diagnosis using lossless 3D CT images: evaluation of GPT-4.1 and GPT-4o for patient-level malignancy assessment.
[PURPOSE] Large vision-language models (VLMs), such as GPT-4.1 and GPT-4o, have shown strong potential in medical tasks. However, their application in lossless 3D medical image analysis is still underexplored. This study proposes a GPT-base…
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Patient-reported outcomes with a personalized follow-up program after lung cancer resection: A single-center randomized controlled trial.
[OBJECTIVE] This study aims to determine the impact of PROM with a personalized follow-up program on the evaluation of quality of life and self-management for patients after lung cancer resection. [METHODS] Given a formal power calculation…
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Personalized treatment of HER2-positive lung adenocarcinoma using Human Organoid Drug Sensitivity Test.
Human Epidermal Growth Factor Receptor 2 (HER2) mutations account for approximately 3% of non-small cell lung cancer (NSCLC) patients. Currently, targeted therapies for HER2-mutant NSCLC include HER2 tyrosine kinase inhibitors (TKIs) and HE…
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Prediction of high-risk factor in early-stage lung cancer: micropapillary adenocarcinoma.
[OBJECTIVE] To identify independent risk factors for micropapillary adenocarcinoma (MPA) in lung adenocarcinoma, a subtype often associated with poor prognosis, in order to support preoperative risk assessment and treatment planning. [METH…
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Integrated radiopathomics nomogram for predicting angiogenic microvascular patterns in NSCLC: a dual-center validation study.
[BACKGROUND] To develop and validate an integrated radiopathomics nomogram combining multiphase CT images, H&E-stained slides, and clinicopathological variables for predicting microvascular patterns (MVPs) in non-small cell lung cancer (NSC…
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Costs and benefits of whole-exome, whole-transcriptome sequencing versus 50-gene panels for genomic profiling in solid tumors.
[AIMS] The rapid development of therapies linked to molecular biomarkers has increased the importance of next-generation sequencing (NGS)-based tumor profiling to guide treatment decisions. Technology has enabled more comprehensive clinical…
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Comparison of Functional Outcomes Between Robotic and Laparoscopic Surgery in Rectal Cancer Patients: Systematic Review and Meta-Analysis.
[BACKGROUND] Robotic and laparoscopic approaches are widely used for rectal cancer surgery. Although robotic systems provide enhanced visualization and dexterity, it remains unclear whether these advantages improve postoperative urinary and…
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The impact of three-dimensional simulation and virtual reality technologies on surgical decision-making and postoperative satisfaction in aesthetic surgery: a preliminary study.
TL;DR3D simulation enhances patient engagement and expectation management across various aesthetic procedures and serves as a complementary tool rather than a definitive factor in decision-making.
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