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Despite the emerging role of the gut microbiome in colorectal cancer (CRC), its significance in early-onset CRC (EOCRC, …

[OBJECTIVE] This study sought to identify neurotransmitter receptor-related genes (NR-RGs) that are critically involved in non-small cell lung cancer (NSCLC) through bioinformatics approaches. [METHODS] The TCGA-NSCLC dataset was utilized …

[BACKGROUND] Transbronchial cryobiopsy (TBCB) is a minimally invasive technique that yields larger specimens than conventional transbronchial forceps biopsies (TBFB) and demonstrates superior diagnostic rates for interstitial lung diseases.…

[BACKGROUND] Clarification of the molecular mechanism of malignant tumor progression, identification of the key signaling pathways and molecules involved in the processes of invasion and metastasis, and identification of new targets and str…

[OBJECTIVE] To investigate and compare the severity and prevalence of financial hardship among lung cancer patients and their caregivers in two institution-based samples from Hong Kong and Mainland China, emphasizing regional differences in…

[PURPOSE] Microscopy-based cancer cell classification traditionally relies on cell-based morphological features, while subcellular organelle organization remains underutilized. Existing machine learning methods often require manual preproce…

[BACKGROUND] Breast cancer (BC) is a major cause of cancer-related morbidity and mortality in women, with its development linked to circadian rhythm disruption. This study employs two-sample bidirectional Mendelian randomization (MR) to exp…

Advancing age and deregulated obesity are well-established risk factors for breast cancer risk. While epigenetic ageing, a measure of biological ageing, has been linked to breast cancer risk, prior studies have mainly focused on blood-based…

[BACKGROUND] Menopausal hormone therapy (MHT) is widely prescribed for alleviating menopausal symptoms. Prior studies have mainly focused on individual hormone therapy formulations. This meta-analysis comprehensively synthesized evidence ac…

[BACKGROUND] Determination of estrogen receptor (ER) and progesterone receptor (PR) status is critical for breast cancer subtyping and guiding endocrine therapy. Although immunohistochemistry (IHC) remains the diagnostic gold standard, it i…

The application of nanoparticles (NPs) in medicine as delivery platforms has experienced a significant expansion in the past decade and as a result, various imaging techniques have been applied to monitor cellular NP uptake. Although, high-…

Rapid and reliable detection of EGFR exon 19 deletion (19del) is important for precision treatment of non-small cell lung cancer, yet current genotyping methods remain poorly suited for point-of-care testing (POCT). This limitation is parti…

Fast, noninvasive and cost-effective methods for screening colorectal cancer (CRC) before uncomfortable colonoscopy are highly desirable. This study aimed to explore the feasibility of using near-infrared spectroscopy (NIRS) combined with a…

[BACKGROUND] A consistent correlation has been highlighted between screening-based mental health indicators and women suffering from breast cancer (BC), which significantly reduced their related quality of life perceptions. This systematic …

[BACKGROUND] Rapid detection of drug-resistant leukemia played a crucial role in formulating appropriate treatment plans for patients and improving their prognosis. In this research, an integrated optofluidic platform was developed to detec…

Tumor biomarkers are crucial for early cancer diagnosis. Liquid biopsy via mRNA profiling in blood offers a sensitive and non-invasive approach, but current methods are often complex, time-consuming, expensive, and ill-suited for point-of-c…

TL;DRTSPAN32 emerges as a molecule involved in the biology of B-ALL with prognostic value, consistent expression across age groups, and involvement in key signaling pathways highlight its potential as a biomarker for B-ALL.

TL;DRDynamic within-cow PVL fluctuations are highlighted and an association between BLV PVL and reproductive performance is suggested to suggest an association between BLV PVL and reproductive performance.

Direct mass spectrometry (MS) analysis of human tissues at the molecular level has great potential for clinical diagnosis and biomarker discovery. However, conventional MS-based analytical methods often require complicated and time-consumin…

[BACKGROUND] Prognostic biomarker panels identified through bulk sequencing approaches have shown utility in localized prostate cancer but are limited by underlying molecular heterogeneity. Spatial transcriptomics offers a complementary app…