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Targeting programmed cell death protein 1 (PD-1) and cytotoxic T-lymphocyte-associated protein 4 (CTLA-4) with immune checkpoint inhibitors (ICIs) has improved survival across multiple cancer types, but the variability in patient response h…

CAR T cell therapy is a promising immunotherapy for hematologic malignancies, yet early prediction of outcomes and adverse events remains difficult, especially in small real-world cohorts. We retrospectively analyzed 14 adult patients with …

[BACKGROUND] Contemporary, systematic comparisons of prostate cancer (PCa) across the entire age spectrum regarding incidence, pathology, treatment, and long-term outcomes remain lacking. [METHODS] Patients were identified from the Surveil…

[BACKGROUND] Immunotherapy offers potential benefits for recurrent or metastatic cervical cancer (R/M CC), yet personalized predictive tools are essential for optimizing treatment. This study aims to develop a nomogram integrating nutrition…

The inhibitory receptor leukocyte immunoglobulin-like receptor B2 (LILRB2), expressed on myeloid cells like monocytes and tumor-resident myeloid cells, sustains an immunosuppressive tumor microenvironment and promotes tumor progression. Pha…

[AIM] Conventional therapies in Japan for relapsed or refractory large B-cell lymphoma (r/r LBCL) require intravenous infusion (IV), while epcoritamab is administered subcutaneously. Despite the expected quality of life (QOL) improvement fr…

[BACKGROUND] The role of albumin-to-alkaline phosphatase ratio (AAPR) in predicting complications in elderly gastric cancer (GC) patients is unclear. [METHODS] This retrospective study included 358 elderly GC patients (≥60 years of age) wh…

[AIMS] Early detection of hepatocellular carcinoma (HCC) in patients with compensated cirrhosis (CC) is critical for improving prognosis. The GAAD algorithm (gender [biological sex], age, alpha-fetoprotein [AFP], protein induced by vitamin …

[BACKGROUND] Chronic hepatitis B (CHB) is a major cause of hepatocellular carcinoma (HCC). In patients receiving CHB treatment, coexistence of steatotic liver disease (SLD) and cardiometabolic risk factors (CMRFs) markedly influence HCC ris…

[AIM] This study aims to evaluate the cost-effectiveness of atezolizumab plus bevacizumab as first-line systemic therapy for unresectable hepatocellular carcinoma (uHCC) in Malaysia, compared with the current standard treatments in the Mala…

TGF-β promotes progression and metastasis in later stages of tumour development, and inhibitors targeting TGF-β or its receptor have faced clinical limitations due to toxicity and poor selectivity. This study aimed to identify novel TGFβR1 …

Human Epidermal Growth Factor Receptor 2 (HER2) mutations account for approximately 3% of non-small cell lung cancer (NSCLC) patients. Currently, targeted therapies for HER2-mutant NSCLC include HER2 tyrosine kinase inhibitors (TKIs) and HE…

[BACKGROUND] To develop and validate an integrated radiopathomics nomogram combining multiphase CT images, H&E-stained slides, and clinicopathological variables for predicting microvascular patterns (MVPs) in non-small cell lung cancer (NSC…

[AIM] Anti-PD-(L)1 agents, inhibitors of programmed cell death protein 1 (PD-1) or its ligand (PD-L1), are established therapies that improve cancer management as well as the disease and societal burden of specific metastatic and early-stag…

[BACKGROUND] Neoadjuvant chemotherapy (NAC) has increased heterogeneity in regional axillary management. The optimal strategy remains uncertain for patients with clinically node-positive (cN+) breast cancer (BC) who convert to pathologicall…

[BACKGROUND] Breast cancer (BC) remains a major global health concern, accounting for 11.7% of all cancer cases and ranking as the second leading cause of female cancer-related deaths worldwide. Increasing evidence highlights the interplay …

[BACKGROUND] Despite the availability of several chemotherapeutic regimens for early-stage breast cancer (BC), the ideal combination and dosing strategy remain to be defined. Thus, we conducted a network meta-analysis (NMA) comparing the cu…

This study aimed to systematically analyze the research status, hotspots, and trends of oncolytic virotherapy (OV) for hepatocellular carcinoma (HCC) from 2000 to mid-2025, scientifically predict future directions, facilitate clinical trans…

TL;DRIt is indicated that combination therapies, most notably 5-FU’s+ corticoids’+ YAG:Laser, offer the greatest benefit, and data for novel agents suggest potential, while data for novel agents suggest potential.

The application of nanoparticles (NPs) in medicine as delivery platforms has experienced a significant expansion in the past decade and as a result, various imaging techniques have been applied to monitor cellular NP uptake. Although, high-…