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[BACKGROUND] The incidence of lung diseases has been increasing in recent years, especially lung cancer and interstitial lung disease. However, the diagnosis of lung diseases such as lung cancer and ILD still has some limitations. Therefore…

TL;DRThis review summarizes current progress in FAP-targeted radiopharmaceuticals and outlines strategies to enhance their therapeutic applicability through different strategies that lead to prolonged tumor retention.

TL;DRA case of a 36-year-old man with medullary thyroid carcinoma who developed lung metastases 10 years post-total thyroidectomy who developed lung metastases 10 years post-total thyroidectomy is presented, suggesting the po…

TL;DRA case of hepatocellular carcinoma with abdominal pain after initiation of pembrolizumab is presented, and 68Ga-FAPi PET/CT highlighted FAPi avid soft tissue density in the paraaortic and presacral regions with diffusely…

TL;DRAlF-NOTA-FAPI PET/CT shows promise as a valuable tool for radiotherapy planning in lung cancer, providing accurate target delineation and improved sparing of critical organs.

TL;DRCritical manufacturing determinants are identified, including the necessity for upper passage limits and standardised isolation protocols, and a translational framework that integrates mechanism-based potency assays, suc…

[BACKGROUND] Breast cancer (BC) is a biologically heterogeneous disease, and no single imaging modality captures the full spectrum of phenotypes across all stages of the disease. This review summarizes advances in receptor-targeted nuclear …

[OBJECTIVE] This study aimed to compare the detection rates and uptake values of gallium-68 (⁶⁸Ga)-labeled fibroblast activation protein inhibitor (FAPI) PET/CT with those of fluorine-18 (¹⁸F)- labeled fluorodeoxyglucose (FDG) PET/CT in pat…

This study aimed to compare the performance of Ga-labeled fibroblast activation protein inhibitor 46 ([Ga]Ga-FAPI-46) PET/CT and [F]FDG PET/CT in characterizing unclear hepatic lesions. We prospectively evaluated 59 patients with suspected…

Lymphoma is a highly heterogeneous hematologic malignancy, for which precise diagnosis and staging are crucial for treatment planning. Although fluorine-18 fluorodeoxyglucose PET/computed tomography (18F-FDG PET/CT) is the current 'gold sta…

A 60-year-old woman with synchronous papillary and medullary thyroid carcinomas (MTC) underwent total thyroidectomy and adjuvant therapy. In later course of her MTC disease, an elevation of serum calcitonin prompted 68Ga-DOTATATE imaging, r…

[TOPIC IMPORTANCE] The integration of molecular and anatomical imaging-particularly via modalities such as PET/CT, PET/MRI, and emerging total-body PET-has significantly advanced the detection, characterization, and personalized treatment o…

We present 18F-FAPI-74 PET/CT findings before and after proton beam therapy (PBT) in a 71-year-old woman with liver metastasis following pancreatic cancer resection. Before PBT, no uptake was observed on FDG-PET, whereas the lesion was visu…

An 80-year-old man underwent 68 Ga-FAPI and 18 F-FDG PET scans to determine the nature of a liver mass that exhibited high FDG uptake unexpectedly but was FAPI-negative. Postoperative pathology confirmed atypical hepatocellular carcinoma (H…

[PURPOSE] To evaluate the radioactive distribution patterns of [ 68 Ga]Ga-FAPI-04 in primary hepatocellular carcinoma (HCC). [METHODS] Twenty-three primary HCC patients (26 lesions) from a prospective trial (ChiCTR2000039099) underwent bot…

A 37-year-old woman was incidentally found to have a hepatic lesion on ultrasound. Serum tumor markers, including AFP, CEA, and CA19-9, were normal. Gd-EOB-DTPA-enhanced MRI revealed a fat-containing lesion with arterial phase hyperenhancem…

[OBJECTIVES] In this systematic review, we evaluated the accuracy of baseline fibroblast activation protein inhibitor (FAPI)-based PET scans for predicting overall survival (OS), progression-free survival (PFS), and tumor response after tre…