Radioactive Distribution Patterns of [ 68 Ga]Ga-FAPI-04 in Primary Hepatocellular Carcinoma.
[PURPOSE] To evaluate the radioactive distribution patterns of [ 68 Ga]Ga-FAPI-04 in primary hepatocellular carcinoma (HCC).
- p-value P <0.001
- p-value P <0.01
APA
Zhu D, Zhu Y, et al. (2026). Radioactive Distribution Patterns of [ 68 Ga]Ga-FAPI-04 in Primary Hepatocellular Carcinoma.. Clinical nuclear medicine, 51(4), 320-324. https://doi.org/10.1097/RLU.0000000000006345
MLA
Zhu D, et al.. "Radioactive Distribution Patterns of [ 68 Ga]Ga-FAPI-04 in Primary Hepatocellular Carcinoma.." Clinical nuclear medicine, vol. 51, no. 4, 2026, pp. 320-324.
PMID
41649855
Abstract
[PURPOSE] To evaluate the radioactive distribution patterns of [ 68 Ga]Ga-FAPI-04 in primary hepatocellular carcinoma (HCC).
[METHODS] Twenty-three primary HCC patients (26 lesions) from a prospective trial (ChiCTR2000039099) underwent both [ 18 F]FDG and [ 68 Ga]Ga-FAPI-04 PET/CT within 1 week. Uptake at tumor margins versus centers was compared.
[RESULTS] FAPI-04 uptake was significantly higher at tumor margins than centers (SUVmax, P <0.001; SUVmean, P <0.01). As SUVmax thresholds increased, FAPI volume of interest concentrated at the margins and decreased sharply in the centers.
[CONCLUSIONS] [ 68 Ga]Ga-FAPI-04 PET/CT demonstrated higher marginal uptake and pronounced central heterogeneity (low-SUV centers) in HCC. Strong peripheral uptake supports the use of FAP-targeted fluorescence-guided surgery and targeted treatment of marginal residual/recurrent disease, while low central uptake may limit FAP-targeted therapy.
[METHODS] Twenty-three primary HCC patients (26 lesions) from a prospective trial (ChiCTR2000039099) underwent both [ 18 F]FDG and [ 68 Ga]Ga-FAPI-04 PET/CT within 1 week. Uptake at tumor margins versus centers was compared.
[RESULTS] FAPI-04 uptake was significantly higher at tumor margins than centers (SUVmax, P <0.001; SUVmean, P <0.01). As SUVmax thresholds increased, FAPI volume of interest concentrated at the margins and decreased sharply in the centers.
[CONCLUSIONS] [ 68 Ga]Ga-FAPI-04 PET/CT demonstrated higher marginal uptake and pronounced central heterogeneity (low-SUV centers) in HCC. Strong peripheral uptake supports the use of FAP-targeted fluorescence-guided surgery and targeted treatment of marginal residual/recurrent disease, while low central uptake may limit FAP-targeted therapy.
MeSH Terms
Humans; Carcinoma, Hepatocellular; Liver Neoplasms; Male; Female; Middle Aged; Positron Emission Tomography Computed Tomography; Aged; Adult; Organophosphorus Compounds; Quinolines
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