The diagnostic value of ⁶⁸Ga-FAPI PET/CT in patients with suspicious recurrent or metastatic differentiated thyroid cancer: a comparative study.
2/5 보강
PICO 자동 추출 (휴리스틱, conf 2/4)
유사 논문P · Population 대상 환자/모집단
56 patients with elevated Tg, positive anti-Tg antibodies, or thyroid ultrasound suggesting recurrence or metastasis was enrolled.
I · Intervention 중재 / 시술
추출되지 않음
C · Comparison 대조 / 비교
추출되지 않음
O · Outcome 결과 / 결론
Our findings indicate that ⁶⁸Ga-FAPI PET/CT does not demonstrate significantly superior diagnostic performance when compared to ¹⁸F-FDG PET/CT in patients with recurrent or metastatic DTC.
OpenAlex 토픽 ·
Peptidase Inhibition and Analysis
Bladder and Urothelial Cancer Treatments
Connective tissue disorders research
[OBJECTIVE] This study aimed to compare the detection rates and uptake values of gallium-68 (⁶⁸Ga)-labeled fibroblast activation protein inhibitor (FAPI) PET/CT with those of fluorine-18 (¹⁸F)- labele
- p-value p=0.029
- p-value p=0.017
APA
Jiewei Liu, Zhengjie Wang, et al. (2026). The diagnostic value of ⁶⁸Ga-FAPI PET/CT in patients with suspicious recurrent or metastatic differentiated thyroid cancer: a comparative study.. BMC medical imaging. https://doi.org/10.1186/s12880-026-02358-4
MLA
Jiewei Liu, et al.. "The diagnostic value of ⁶⁸Ga-FAPI PET/CT in patients with suspicious recurrent or metastatic differentiated thyroid cancer: a comparative study.." BMC medical imaging, 2026.
PMID
42010490 ↗
Abstract 한글 요약
[OBJECTIVE] This study aimed to compare the detection rates and uptake values of gallium-68 (⁶⁸Ga)-labeled fibroblast activation protein inhibitor (FAPI) PET/CT with those of fluorine-18 (¹⁸F)- labeled fluorodeoxyglucose (FDG) PET/CT in patients with suspicious recurrent or metastatic differentiated thyroid cancer (DTC), and to explore the association of these rates and values with diverse clinical-pathological characteristics and degrees of differentiation based on visual analysis and semi-quantitative parameters.
[METHODS] A retrospective cohort comprising 56 patients with elevated Tg, positive anti-Tg antibodies, or thyroid ultrasound suggesting recurrence or metastasis was enrolled. All patients had previously undergone ⁶⁸Ga-FAPI PET/CT and ¹⁸F-FDG PET/CT scans. Lesion detection and uptake values were analyzed visually and semi-quantitatively, with final diagnosis confirmed by histopathology or clinical follow-up.
[RESULTS] ¹⁸F-FDG PET/CT identified more positive patients (86% vs. 76%) and demonstrated a higher detection rate in lymph node metastases (71% vs. 59%, p=0.029). ⁶⁸Ga-FAPI showed higher uptake (SUVmax) in pulmonary metastases (3.31 vs. 1.74, p=0.017) but a lower tumor-to-background ratio (TBR) in lymph nodes (2.20 vs. 4.10, p<0.001). Among the clinical and pathological characteristics assessed, Tg levels, short axis diameter (SAD) of lymph node, and iodine uptake displayed significant differences between ⁶⁸Ga-FAPI uptake negative (FAPI-) and ⁶⁸Ga-FAPI uptake positive (FAPI+) groups (p=0.025, p<0.001, p=0.003). However, only the SAD of lymph node showed a moderate positive correlation with the SUVmax value of ⁶⁸Ga-FAPI in the lesion (r=0.393, p=0.042).
[CONCLUSION] Our findings indicate that ⁶⁸Ga-FAPI PET/CT does not demonstrate significantly superior diagnostic performance when compared to ¹⁸F-FDG PET/CT in patients with recurrent or metastatic DTC. Nevertheless, for patients with enlarged metastatic lymph nodes, elevated Tg levels, and iodine-affinity lesions, ⁶⁸Ga-FAPI PET/CT could represent a valuable diagnostic tool.
[METHODS] A retrospective cohort comprising 56 patients with elevated Tg, positive anti-Tg antibodies, or thyroid ultrasound suggesting recurrence or metastasis was enrolled. All patients had previously undergone ⁶⁸Ga-FAPI PET/CT and ¹⁸F-FDG PET/CT scans. Lesion detection and uptake values were analyzed visually and semi-quantitatively, with final diagnosis confirmed by histopathology or clinical follow-up.
[RESULTS] ¹⁸F-FDG PET/CT identified more positive patients (86% vs. 76%) and demonstrated a higher detection rate in lymph node metastases (71% vs. 59%, p=0.029). ⁶⁸Ga-FAPI showed higher uptake (SUVmax) in pulmonary metastases (3.31 vs. 1.74, p=0.017) but a lower tumor-to-background ratio (TBR) in lymph nodes (2.20 vs. 4.10, p<0.001). Among the clinical and pathological characteristics assessed, Tg levels, short axis diameter (SAD) of lymph node, and iodine uptake displayed significant differences between ⁶⁸Ga-FAPI uptake negative (FAPI-) and ⁶⁸Ga-FAPI uptake positive (FAPI+) groups (p=0.025, p<0.001, p=0.003). However, only the SAD of lymph node showed a moderate positive correlation with the SUVmax value of ⁶⁸Ga-FAPI in the lesion (r=0.393, p=0.042).
[CONCLUSION] Our findings indicate that ⁶⁸Ga-FAPI PET/CT does not demonstrate significantly superior diagnostic performance when compared to ¹⁸F-FDG PET/CT in patients with recurrent or metastatic DTC. Nevertheless, for patients with enlarged metastatic lymph nodes, elevated Tg levels, and iodine-affinity lesions, ⁶⁸Ga-FAPI PET/CT could represent a valuable diagnostic tool.
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