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Cost-efficiency modeling of conversion to biosimilar rituximab-based R-CHOP in diffuse large B-cell lymphoma in medicare.
[BACKGROUND] Rituximab-pvvr (Ruxience), -abbs (Truxima), and -arrx (Riabni) are biologic therapies approved by the United States Food and Drug Administration (FDA) as biosimilars to originator rituximab (Rituxan). Each is approved for the t…
FULLTEXT: Computer Simulation -
Cost-effectiveness of the GAAD algorithm for hepatocellular carcinoma surveillance of patients with compensated cirrhosis: a model-based analysis using Italian real-world data.
[AIMS] Early detection of hepatocellular carcinoma (HCC) in patients with compensated cirrhosis (CC) is critical for improving prognosis. The GAAD algorithm (gender [biological sex], age, alpha-fetoprotein [AFP], protein induced by vitamin …
FULLTEXT: Computer Simulation -
Impact of offering blood-based testing alongside existing modalities for colorectal cancer screening among those who previously declined screening: an economic evaluation.
[AIM] Inadequate adherence to colorectal cancer screening reduces individual and population level health benefits. Blood-based tests offer a new modality that may help patients overcome barriers, but there are concerns about the impact of p…
FULLTEXT: Computer Simulation -
Rabdosin B suppresses proliferation of nonsmall cell lung cancer by regulating the SRC/PI3K/AKT signaling pathway.
[CONTEXT] Rabdosin B (RB), an active compound derived from the Chinese herb (Burm. f.) H. Hara, has demonstrated inhibitory effects on non-small cell lung cancer (NSCLC) cell proliferation in prior studies. However, its precise mechanism o…
FULLTEXT: Computer Simulation -
A system dynamics modelling protocol to evaluate the impact of a health financing mechanism for breast cancer pharmacotherapies in Malaysia.
[INTRODUCTION] The rising cost of targeted breast cancer therapies challenges financial sustainability and equitable access in dual-tier health systems. In Malaysia, public cancer care is highly subsidized but budget constrained, shifting p…
FULLTEXT: Computer Simulation -
Endodontic implications of hypercementosis: A systematic review of anatomical challenges and therapeutic strategies.
TL;DRA stepwise approach, ranging from clinical monitoring in asymptomatic cases to surgical interventions is recommended, and the integration of advanced imaging technologies and individualized treatment planning is essentia…
FULLTEXT: Computer Simulation -
The impact of three-dimensional simulation and virtual reality technologies on surgical decision-making and postoperative satisfaction in aesthetic surgery: a preliminary study.
TL;DR3D simulation enhances patient engagement and expectation management across various aesthetic procedures and serves as a complementary tool rather than a definitive factor in decision-making.
FULLTEXT: Computer Simulation -
Smart graphene-enhanced ceramic material refractive index sensor simulation design developed for highly sensitive breast Cancer detection optimized with machine learning.
Based on the surface plasmon resonance (SPR) technique, the proposed biosensor is investigated as an SPR-based sensing platform for detecting breast cancer cells, specifically MCF-7 and MDA-MB-231 cells. Developed biosensor features an octa…
FULLTEXT: Computer Simulation -
From "Simulation" to "Mirror": Gene editing and humanization redefines the next-generation precision oncology animal model.
Patient-derived xenograft (PDX) models, although conventionally used in oncology, exhibit critical limitations: they frequently lose patient-specific genetic mutations and lack the human leukocyte antigen (HLA) diversity essential for immun…
FULLTEXT: Computer Simulation -
Design, synthesis, and mechanistic study of bispecific small molecules-based phenyl pyrazolopyrimidinone scaffold as dual-targeting VEGFR and PD-L1 immune checkpoint in hepatocellular carcinoma.
In this work, a new series of N-arylmethylene/heterylmethylene-2-(4-oxo-1-phenyl-1,4-dihydro-5H-pyrazolo[3,4-d]pyrimidin-5-yl)acetohydrazide 8a-l was synthesized via the condensation reaction of acetohydrazide 6 with various aromatic aldehy…
FULLTEXT: Computer Simulation -
Artificial intelligence in biomaterials for oral oncology.
Oral cancer and oral potentially malignant disorders (OPMDs) remain a significant challenge in diagnosis and therapy, primarily due to inherent limitations in early detection, targeted treatment, and postoperative rehabilitation. Convention…
FULLTEXT: Computer Simulation -
Design, synthesis and docking studies of new benzothiophene and benzothienopyran derivatives as topoisomerase I inhibitors with potential immunomodulatory action via cGAS-STING signaling pathway.
Cancer remains a major global health challenge, and the development of new therapeutic agents is urgently needed to overcome poor selectivity and multi-drug resistance. Targeting DNA replication enzymes such as topoisomerase I (Topo I), whi…
FULLTEXT: Computer Simulation -
YEATS2/TAK1 axis mediates TGF-β1 driven adaptive resistance to sorafenib in hepatocellular carcinoma.
Although Sorafenib can effectively prolong the median survival time of HCC patients with limited side effects, it may cause many patients to develop drug resistance, becoming a barrier to extending the overall survival time of HCC patients.…
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Discovery of 8-sulfonamidoquinolines as anti-proliferative agents against colorectal cancer: design, synthesis, and biological evaluation.
TL;DRCompound II-2, an 8-sulfonamidoquinoline derivative, emerged with significantly enhanced anti-proliferative activity against HCT116 cells, and may be candidate molecules for the treatment of colon cancer and worthy for f…
FULLTEXT: Computer Simulation -
Structure-guided discovery of 4-phenyl-5-p-tolyloxymethyl-4H-1,2,4-triazole thioethers as 15-lipoxygenase inhibitors using integrated in vitro, structure-activity relationship, in silico, cytotoxicity towards MCF-7 cell line, DNA docking and MD simulation methods.
15-Lipoxygenase (15-LOX) has emerged as a strategic target for therapeutic intervention in inflammatory diseases and the advancement of malignancy owing to its involvement in arachidonic acid metabolism. In this regard, in the pursuit of ne…
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Decoding the impact of nsSNP variants on BCL6 function through integrated computational analysis.
TL;DRIt could be concluded that selected nsSNPs could lead to impaired BCL6 transcriptional repressive function due to loss of stability and binding affinity towards its corepressors.
FULLTEXT: Computer Simulation -
Computational hybrid framework integrating clinical-mutation profiling and physics-based simulations to predict structural tolerance of Bruton tyrosine kinase (BTK) and sustained ARQ 531 binding.
TL;DRAssessing the impact of clinical substitutions on the structure and binding of ARQ 531(Nemtabrutinib), the most potent BTK inhibitor, confirms that ARQ 531 remains a significant investigational therapy specifically for o…
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Practice development perspective of RTT contouring in online adaptive radiotherapy for prostate cancer: A single-centre cost-consequence analysis.
Technological advances in online adaptive radiotherapy (oART) are set to revolutionise the treatment of prostate cancer (PCa). Yet, the need for a multi-disciplinary team oversight at every fraction remains a significant resource barrier to…
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Biomarker discovery and drug repurposing in hepatocellular carcinoma through transcriptomics, machine learning, network pharmacology, and molecular dynamics.
TL;DRThis in silico study proposes a robust diagnostic gene signature for HCC and identifies tolrestat as a promising repurposing candidate that warrants experimental validation, demonstrating the utility of integrating machi…
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A system biology-based identification of potential biomarker interlinking the effect of anti-diabetic drug, Metformin, on reduced occurrence of hepatocellular carcinoma.
TL;DRThe present findings provide mechanistic insights into Metformin's antitumor effects in an insilico condition and suggest an association between a network of proteins in the disease mechanism and Protein kinase B (AKT1),…
FULLTEXT: Computer Simulation