Clinical application prospects of Nectin-4 in pan-cancer: an analysis based on the Trialtrove database.
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This research analyzes the global landscape of clinical trials focusing on therapies targeting the Nectin cell adhesion molecule 4 (Nectin-4) across various malignancies, using data from the Trialtrov
APA
Li L, Ren F, et al. (2026). Clinical application prospects of Nectin-4 in pan-cancer: an analysis based on the Trialtrove database.. Journal for immunotherapy of cancer, 14(3). https://doi.org/10.1136/jitc-2025-014345
MLA
Li L, et al.. "Clinical application prospects of Nectin-4 in pan-cancer: an analysis based on the Trialtrove database.." Journal for immunotherapy of cancer, vol. 14, no. 3, 2026.
PMID
41807035 ↗
Abstract 한글 요약
This research analyzes the global landscape of clinical trials focusing on therapies targeting the Nectin cell adhesion molecule 4 (Nectin-4) across various malignancies, using data from the Trialtrove database. Analysis of 136 interventional trials reveals a rapidly expanding field dominated by antibody-drug conjugates, particularly in urothelial carcinoma, with significant activity in combination regimens and diverse therapeutic modalities under exploration. These findings emphasize the substantial translational potential of Nectin-4 and highlight key trends shaping its future clinical development.
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Supplementary material
Supplementary material
10.1136/jitc-2025-014345online supplemental file 1
10.1136/jitc-2025-014345online supplemental file 1
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