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Arabidopsis N-methyladenosine reader CPSF30-L recognizes FUE signals to control polyadenylation site choice in liquid-like nuclear bodies.

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Molecular plant 📖 저널 OA 28.1% 2021: 1/3 OA 2023: 1/2 OA 2024: 0/7 OA 2025: 7/15 OA 2026: 5/17 OA 2021~2026 2021 Vol.14(4) p. 571-587 cited 186 OA RCR 8.02 RNA modifications and cancer
TL;DR A new molecular mechanism for m6A-driven phase separation and polyadenylation in plants is uncovered, which enhances the formation of liquid-like CPSF30-L nuclear bodies and leads to late flowering and ABA hypersensitivity.
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PubMed DOI OpenAlex Semantic 마지막 보강 2026-05-05
연도별 인용 (2021–2026) · 합계 186
OpenAlex 토픽 · RNA modifications and cancer HVDC Systems and Fault Protection RNA Research and Splicing

Song P, Yang J, Wang C, Lu Q, Shi L, Tayier S

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Abstract

The biological functions of the epitranscriptomic modification N-methyladenosine (mA) in plants are not fully understood. CPSF30-L is a predominant isoform of the polyadenylation factor CPSF30 and consists of CPSF30-S and an mA-binding YTH domain. Little is known about the biological roles of CPSF30-L and the molecular mechanism underlying its mA-binding function in alternative polyadenylation. Here, we characterized CPSF30-L as an Arabidopsis mA reader whose mA-binding function is required for the floral transition and abscisic acid (ABA) response. We found that the mA-binding activity of CPSF30-L enhances the formation of liquid-like nuclear bodies, where CPSF30-L mainly recognizes mA-modified far-upstream elements to control polyadenylation site choice. Deficiency of CPSF30-L lengthens the 3' untranslated region of three phenotypes-related transcripts, thereby accelerating their mRNA degradation and leading to late flowering and ABA hypersensitivity. Collectively, this study uncovers a new molecular mechanism for mA-driven phase separation and polyadenylation in plants.
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A new molecular mechanism for m6A-driven phase separation and polyadenylation in plants is uncovered, which enhances the formation of liquid-like CPSF30-L nuclear bodies and leads to late flowering an

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APA 7 Song, P., Yang, J., Wang, C., Lu, Q., Shi, L., Tayier, S., & Jia, G. (2021). Arabidopsis n-methyladenosine reader cpsf30-l recognizes fue signals to control polyadenylation site choice in liquid-like nuclear bodies.. Molecular plant, 14(4), 571-587. https://doi.org/10.1016/j.molp.2021.01.014
Vancouver Song P, Yang J, Wang C, Lu Q, Shi L, Tayier S, et al. Arabidopsis N-methyladenosine reader CPSF30-L recognizes FUE signals to control polyadenylation site choice in liquid-like nuclear bodies. Molecular plant. 2021;14(4):571-587. doi:10.1016/j.molp.2021.01.014
AMA 11 Song P, Yang J, Wang C, Lu Q, Shi L, Tayier S, et al. Arabidopsis N-methyladenosine reader CPSF30-L recognizes FUE signals to control polyadenylation site choice in liquid-like nuclear bodies. Molecular plant. 2021;14(4):571-587. doi:10.1016/j.molp.2021.01.014
Chicago Song, P., Yang, J., Wang, C., Lu, Q., Shi, L., Tayier, S., and Jia, G.. 2021. "Arabidopsis N-methyladenosine reader CPSF30-L recognizes FUE signals to control polyadenylation site choice in liquid-like nuclear bodies." Molecular plant 14 (4): 571-587. https://doi.org/10.1016/j.molp.2021.01.014
MLA 9 Song, P., et al. "Arabidopsis N-methyladenosine reader CPSF30-L recognizes FUE signals to control polyadenylation site choice in liquid-like nuclear bodies." Molecular plant, vol. 14, no. 4, 2021, pp. 571-587. doi:10.1016/j.molp.2021.01.014.
PMID 33515768 ↗

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유형영어 표현한국어 / 풀이UMLS CUI출처등장
시술 fue 모발이식 dict 1

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