Autologous platelet-rich plasma: a potential therapeutic tool for promoting hair growth.
💡 한 문장 핵심
자가 platelet-rich plasma: 모발 성장을 촉진하는 잠재적 치료 도구.
5/5 보강
TL;DR
Support is provided for possible clinical application of autologous PRP and its secretory factors for promotion of hair growth using in vivo and in vitro models.
PICO 자동 추출 (휴리스틱, conf 2/4)
유사 논문P · Population 대상 환자/모집단
추출되지 않음
I · Intervention 중재 / 시술
subcutaneous injections of activated PRP, and their results were compared with control mice
C · Comparison 대조 / 비교
추출되지 않음
O · Outcome 결과 / 결론
The injection of mice with activated PRP induced faster telogen-to-anagen transition than was seen on control mice. [CONCLUSIONS] Although few studies tested the effects of activated PRP on hair growth, this research provides support for possible clinical application of autologous PRP and its secretory factors for promotion of hair growth.
📑 코퍼스 인용 관계
· 인용됨 73
📑 인용한 논문 (6) ▾
- Randomized Controlled Trial Study to Evaluate the Efficacy of Combination Therapy with Dip… International journal of trichology · 2025
- Bibliometric Analysis of Platelet-Rich Plasma Treatment for Hair Restoration, Facial Rejuv… Skin appendage disorders · 2025
- Comparison of single-spin to double-spin platelet-rich plasma centrifugation methods in th… Frontiers in medicine · 2025
- Intralesional Platelet-Rich Plasma Injection in Patients with Recalcitrant Alopecia Areata… Sisli Etfal Hastanesi tip bulteni · 2025
- Updates in Treatment for Androgenetic Alopecia. Annals of dermatology · 2025
- The 100 most cited articles in androgenetic alopecia: A bibliometric analysis. Medicine · 2025
연도별 인용 (2012–2026) · 합계 381
OpenAlex 토픽 ·
Hair Growth and Disorders
Periodontal Regeneration and Treatments
Facial Rejuvenation and Surgery Techniques
🇰🇷 한글 요약 🌐 Abstract
【연구 목적】
자가 혈소판 다량 혈장(autologous platelet-rich plasma, PRP)이 상처 치유를 촉진하는 능력으로 인해 성형외과 및 피부과에서 주목받고 있으나, 모발 성장에 대한 구체적인 효과와 기전은 명확히 규명되지 않았다. 본 연구는 자가 PRP가 모발 성장에 미치는 영향을 체내(in vivo) 및 체외(in vitro) 모델에서 규명하여 임상적 적용 가능성을 평가하는 것을 목적으로 한다.
【방법】
이중 원심분리법(double-spin method)으로 제조된 활성화된 PRP를 모유두(dermal papilla, DP) 세포에 적용하여 증식 효과를 측정하고, 관련 신호 전달 경로를 평가하였다. 또한, 마우스의 피하 주사를 통해 활성화된 PRP의 체내 효과를 대조군과 비교하는 실험을 수행하였다.
【주요 결과】
활성화된 PRP는 DP 세포의 증식을 증가시켰으며, extracellular signal-regulated kinase (ERK)와 Akt 신호 전달 경로를 자극하였다. 모발 성장의 강력한 자극제인 Fibroblast growth factor 7 (FGF-7)와 beta-catenin이 DP 세포에서 상향 조절되었다. 또한, PRP 주사된 마우스는 대조군에 비해 telogen(휴지기)에서 anagen(성장기)로의 전환이 더 빠르게 유도되었다.
【임상적 시사점 (성형외과 의사 관점)】
성형외과 의사로서 모발 이식(hair transplantation)이나 안면거상술(rhytidectomy) 후 부종 및 통증 감소뿐만 아니라 모발 밀도 증진에 PRP를 활용할 수 있는 기전적 근거를 확보하였다. 모유두 세포의 증식과 성장기 전환을 촉진하는 FGF-7 및 beta-catenin 경로의 활성화는 모발 재생술의 성공률을 높이기 위한 보조 치료제로 PRP 사용의 타당성을 지지한다. 임상 현장에서는 이중 원심분리법을 통해 제조된 활성화된 PRP를 모발 이식 부위나 탈모 부위에 국소 주사함으로써 모낭의 활성화를 유도할 수 있다. 이는 특히 모발 이식 후 생존율 향상이나 안면 수술 후 회복 기간 단축을 위한 다학제적 접근에서 유용한 도구로 고려될 수 있다. 환자 상담 시 PRP가 모발 성장 관련 성장 인자를 조절하여 모낭 주기를 촉진한다는 과학적 근거를 제시하여 치료 기대치를 현실적으로 설정하는 데 도움이 된다.
[BACKGROUND] Recently, autologous platelet-rich plasma (PRP) has attracted attention in various medical fields, including plastic and orthopedic surgery and dermatology, for its ability to promote wound healing. PRP has been tested during facelift and hair transplantation to reduce swelling and pain and to increase hair density.
[OBJECTIVE] To investigate the effects of PRP on hair growth using in vivo and in vitro models.
[METHODS] PRP was prepared using the double-spin method and applied to dermal papilla (DP) cells. The proliferative effect of activated PRP on DP cells was measured. To understand the mechanisms of activated PRP on hair growth, we evaluated signaling pathways. In an in vivo study, mice received subcutaneous injections of activated PRP, and their results were compared with control mice.
[RESULTS] Activated PRP increased the proliferation of DP cells and stimulated extracellular signal-regulated kinase (ERK) and Akt signaling. Fibroblast growth factor 7 (FGF-7) and beta-catenin, which are potent stimuli for hair growth, were upregulated in DP cells. The injection of mice with activated PRP induced faster telogen-to-anagen transition than was seen on control mice.
[CONCLUSIONS] Although few studies tested the effects of activated PRP on hair growth, this research provides support for possible clinical application of autologous PRP and its secretory factors for promotion of hair growth.
[OBJECTIVE] To investigate the effects of PRP on hair growth using in vivo and in vitro models.
[METHODS] PRP was prepared using the double-spin method and applied to dermal papilla (DP) cells. The proliferative effect of activated PRP on DP cells was measured. To understand the mechanisms of activated PRP on hair growth, we evaluated signaling pathways. In an in vivo study, mice received subcutaneous injections of activated PRP, and their results were compared with control mice.
[RESULTS] Activated PRP increased the proliferation of DP cells and stimulated extracellular signal-regulated kinase (ERK) and Akt signaling. Fibroblast growth factor 7 (FGF-7) and beta-catenin, which are potent stimuli for hair growth, were upregulated in DP cells. The injection of mice with activated PRP induced faster telogen-to-anagen transition than was seen on control mice.
[CONCLUSIONS] Although few studies tested the effects of activated PRP on hair growth, this research provides support for possible clinical application of autologous PRP and its secretory factors for promotion of hair growth.
【연구 목적】 자가 혈소판 다량 혈장(autologous platelet-rich plasma, PRP)이 상처 치유를 촉진하는 능력으로 인해 성형외과 및 피부과에서 주목받고 있으나, 모발 성장에 대한 구체적인 효과와 기전은 명확히 규명되지 않았다.
APA 7
Li, Z. J., Choi, H. I., Choi, D. K., Sohn, K. C., Im, M., Seo, Y. J., Lee, Y. H., Lee, J. H., & Lee, Y. (2012). Autologous platelet-rich plasma: A potential therapeutic tool for promoting hair growth.. Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.], 38(7 Pt 1), 1040-6. https://doi.org/10.1111/j.1524-4725.2012.02394.x
Vancouver
Li ZJ, Choi HI, Choi DK, Sohn KC, Im M, Seo YJ, et al. Autologous platelet-rich plasma: a potential therapeutic tool for promoting hair growth. Derm. surg. : offi. publ. Amer. Soci. Derm. Surg. [et al.]. 2012;38(7 Pt 1):1040-6. doi:10.1111/j.1524-4725.2012.02394.x
AMA 11
Li ZJ, Choi HI, Choi DK, Sohn KC, Im M, Seo YJ, et al. Autologous platelet-rich plasma: a potential therapeutic tool for promoting hair growth. Derm. surg. : offi. publ. Amer. Soci. Derm. Surg. [et al.]. 2012;38(7 Pt 1):1040-6. doi:10.1111/j.1524-4725.2012.02394.x
Chicago
Li, Z. J., Choi, H. I., Choi, D. K., Sohn, K. C., Im, M., Seo, Y. J., Lee, Y. H., Lee, J. H., and Lee, Y.. 2012. "Autologous platelet-rich plasma: a potential therapeutic tool for promoting hair growth." Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.] 38 (7 Pt 1): 1040-6. https://doi.org/10.1111/j.1524-4725.2012.02394.x
MLA 9
Li, Z. J., et al. "Autologous platelet-rich plasma: a potential therapeutic tool for promoting hair growth." Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.], vol. 38, no. 7 Pt 1, 2012, pp. 1040-6. doi:10.1111/j.1524-4725.2012.02394.x.
PMID
22455565 ↗
추출된 의학 개체 (NER)
합병증
상처 wound
전체 NER 표 보기
| 유형 | 영어 표현 | 한국어 / 풀이 | UMLS CUI | 출처 | 등장 |
|---|---|---|---|---|---|
| 시술 | facelift
|
안면거상술 | dict | 1 | |
| 시술 | hair transplantation
|
모발이식 | dict | 1 | |
| 해부 | subcutaneous
|
피하조직 | dict | 1 | |
| 해부 | platelet-rich plasma
|
혈소판 풍부 혈장(PRP) | scispacy | 1 | |
| 해부 | hair
|
모발 | scispacy | 1 | |
| 해부 | cells
|
세포 | scispacy | 1 | |
| 합병증 | wound
|
상처 | scispacy | 1 | |
| 약물 | platelet-rich
|
혈소판풍부 |
C0370220
Platelet rich plasma
|
scispacy | 1 |
| 약물 | PRP
→ platelet-rich plasma
|
혈소판풍부혈장(PRP) |
C0370220
Platelet rich plasma
|
scispacy | 1 |
| 약물 | Akt
|
AKT(단백질인산화효소B) |
C0164786
Proto-Oncogene Proteins c-akt
|
scispacy | 1 |
| 약물 | [RESULTS] Activated PRP
|
scispacy | 1 | ||
| 질환 | swelling
|
부종 |
C0013604
Edema
|
scispacy | 1 |
| 질환 | pain
|
통증 |
C0030193
Pain
|
scispacy | 1 |
| 질환 | dermal papilla
|
scispacy | 1 | ||
| 기타 | hair
|
모발 | scispacy | 1 | |
| 기타 | PRP
→ platelet-rich plasma
|
혈소판풍부혈장(PRP) | scispacy | 1 | |
| 기타 | mice
|
마우스 | scispacy | 1 | |
| 기타 | extracellular signal-regulated kinase
|
scispacy | 1 | ||
| 기타 | Akt
|
AKT(단백질인산화효소B) | scispacy | 1 | |
| 기타 | Fibroblast growth factor 7
|
scispacy | 1 | ||
| 기타 | FGF-7
→ Fibroblast growth factor 7
|
scispacy | 1 | ||
| 기타 | beta-catenin
|
scispacy | 1 | ||
| 기타 | telogen-to-anagen
|
scispacy | 1 |
🏷️ 키워드 / MeSH 📖 같은 키워드 OA만
🤖 이 논문을 인용한 AI 인사이트 · 1건
이 논문은 위 AI 빅데이터 분석에 인용된 근거 논문입니다.
인용 관계
그래프 OA 노드: 7/8 (88%)
· 참조 0편 · 후속 7편
이 논문을 인용한 후속 연구 20
- Advances in Regenerative Stem Cell Therapy in Androgenic Alopecia and Hair Loss: Wnt pathway, Growth…
- The Effect of Platelet-Rich Plasma in Hair Regrowth: A Randomized Placebo-Controlled Trial.
- Androgenetic Alopecia: An Update of Treatment Options.
- Alopecia Areata: Review of Epidemiology, Clinical Features, Pathogenesis, and New Treatment Options.
- Study of platelet-rich plasma injections in the treatment of androgenetic alopecia through an one-ye…
- The effect of autologous activated platelet rich plasma (AA-PRP) injection on pattern hair loss: cli…
- Evaluation of Not-Activated and Activated PRP in Hair Loss Treatment: Role of Growth Factor and Cyto…
- Platelet-rich plasma in androgenic alopecia: myth or an effective tool.
- Regenerative medicine strategies for hair growth and regeneration: A narrative review of literature.
- A systematic summary of survival and death signalling during the life of hair follicle stem cells.
- PI3K/Akt signaling pathway is essential for de novo hair follicle regeneration.
- Platelet-rich plasma for androgenetic alopecia: A review of the literature and proposed treatment pr…
- Platelet-Rich Plasma and Micrografts Enriched with Autologous Human Follicle Mesenchymal Stem Cells …
- Comparative Evaluation of the Clinical Efficacy of PRP-Therapy, Minoxidil, and Their Combination wit…
- A Study to Compare the Efficacy of Platelet-rich Plasma and Minoxidil Therapy for the Treatment of A…
- Hair restoration surgery: challenges and solutions.
- Platelet Rich Plasma and Its Use in Hair Regrowth: A Review.
- Advances in hair growth.
- New and Emerging Therapies for Alopecia Areata.
- Efficacy of platelet-rich plasma in treatment of androgenic alopecia.
함께 등장하는 도메인
이 논문이 속한 카테고리와 같은 논문에서 자주 함께 다뤄지는 카테고리들
같은 제1저자의 인용 많은 논문 (5)
- Artesunate synergizes with sorafenib to induce ferroptosis in hepatocellular carcinoma.
- Site-specific methylation of SRSF2 by SETD2 inhibits MDSC-mediated proinflammatory niche formation in mouse models of myelodysplastic syndrome.
- Predictive role of family dysfunction on psychological morbidity in breast cancer patients.
- [Therapeutic mechanism of Compound Xuanju Capsule on erectile dysfunction].
- Plates versus headless screws for fixation of Mason Type 3 radial head fractures: A systematic review.
🏷️ 같은 키워드 · 무료전문 — 이 논문 MeSH/keyword 기반
📖 비슷한 OA 논문 — 같은 카테고리, 무료 전문 가능
-
Alopecia areata.
TL;DRAlopecia areata is difficult to manage medically, but recent advances in understanding the molecular mechanisms have revealed new treatments and the possibility of remission in the…
-
Treatment options for androgenetic alopecia: Efficacy, side effects, compliance, financial considerations, and ethics.
TL;DRAlthough a variety of medical, surgical, light‐based and nutraceutical treatment options are available to slow or reverse the progression of AGA, it can be challenging to select ap…
-
Hair follicle immune privilege and its collapse in alopecia areata.
TL;DRA key goal for effective AA management is the re‐establishment of a functional HF IP, which will also provide superior protection from disease relapse, and may confer increased sus…
-
Alopecia areata: A multifactorial autoimmune condition.
TL;DRVarious genetic and environmental factors that cause autoimmunity are discussed and the immune mechanisms that lead to hair loss in alopecia areata patients are described.
-
Genome-wide meta-analysis in alopecia areata resolves HLA associations and reveals two new susceptibility loci.
TL;DRThe first meta-analysis of research on AA is performed by combining data from two genome-wide association studies (GWAS), and replication with supplemented ImmunoChip data for a to…