Androgenetic alopecia: an evidence-based treatment update.
💡 한 문장 핵심
안드로겐성 탈모: 근거 기반 치료의 최신 지견
5/5 보강
TL;DR
An assessment of the evidence quality of current publications indicates that oral finasteride and topical minoxidil are the best treatments of androgenetic alopecia.
PICO 자동 추출 (휴리스틱, conf 2/4)
유사 논문P · Population 대상 환자/모집단
MEDLINE, EMBASE and Cochrane Library were searched for systematic reviews, randomized controlled trials, open studies, case reports and relevant studies of the treatment of male and female AGA.
I · Intervention 중재 / 시술
추출되지 않음
C · Comparison 대조 / 비교
추출되지 않음
O · Outcome 결과 / 결론
[LIMITATIONS] Some articles, especially those concerning traditional herbs claimed to promote hair regrowth, were published in non-English, local journals. [CONCLUSIONS] An assessment of the evidence quality of current publications indicates that oral finasteride (for men only) and topical minoxidil (for men and women) are the best treatments of AGA.
📑 코퍼스 인용 관계
· 인용됨 66
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연도별 인용 (2012–2026) · 합계 254
OpenAlex 토픽 ·
Hair Growth and Disorders
Acne and Rosacea Treatments and Effects
Autoimmune and Inflammatory Disorders
🇰🇷 한글 요약 🌐 Abstract
【연구 목적】
전 세계적으로 흔한 만성 질환인 안드로겐 탈모증(Androgenetic alopecia, AGA)의 치료 옵션은 제한적이지만 다양한 비처방 제품이 시판되고 있어, 본 연구는 남성 및 여성 AGA에 대한 의학적이고 비의학적인 치료법의 증거 기반 효과를 체계적으로 평가하고자 한다.
【방법】
미국 의사협회(American College of Physicians)의 증거 평가 방법을 적용하여 MEDLINE, EMBASE, Cochrane Library에서 체계적 문헌 고찰, 무작위 대조 시험, 개방형 연구, 사례 보고 등 관련 문헌을 검색하였다. 수집된 문헌은 증거의 등급과 수준에 따라 분류하여 치료의 효능과 안전성을 평가하였다.
【주요 결과】
남성 AGA의 경우 경구 피나스테리드(oral finasteride)와 국소 미녹시딜 용액(topical minoxidil solution)이 효능과 안전성 측면에서 가장 높은 증거 등급을 보였다. 여성 AGA에서는 국소 미녹시딜 용액이 가장 효과적이고 안전한 치료로 확인되었다. FDA 승인 외의 항호르몬 치료는 그 다음 단계의 증거를 가지며, 약물 치료에 실패한 경우 모낭 단위 이식술(follicular unit hair transplantation)이 대안이 될 수 있으나 결과의 편차가 크다고 보고되었다.
【임상적 시사점 (성형외과 의사 관점)】
성형외과 의사는 안면 상부 및 두피의 모발 재건 및 미용 수술을 수행함에 있어, 약물 치료의 한계와 수술적 접근의 적절성을 판단하는 데 이 근거를 활용할 수 있다. 특히 모발 이식술(hair transplantation)을 고려하는 환자에서 약물 치료의 실패 여부는 수술 적응증을 결정하는 중요한 기준이 되므로, 수술 전 약물 반응력을 평가하는 것이 필수적이다. 피나스테리드와 미녹시딜이 가장 강력한 증거를 가진 치료법임을 인지함으로써, 수술 전후 약물 요법을 병행할 때 환자 상담의 신뢰도를 높일 수 있다. 수술 결과의 편차가 크다는 점은 이식 밀도, 모낭 생존율, 그리고 수술 후 유지 관리에 대한 환자의 기대치를 현실적으로 설정하는 데 도움이 된다. 또한 항호르몬 치료 등 비승인 약물의 사용 가능성은 다학제적 접근 시 내분비학적 배경을 고려한 협진 판단의 근거가 될 수 있다. 전신 상태 평가 측면에서 피나스테리드의 남성 전용 사용 제한은 성별에 따른 수술 계획 및 약물 상호작용 검토 시 중요한 고려사항이다.
[BACKGROUND] Androgenetic alopecia (AGA) is one of the most common chronic problems seen by dermatologists worldwide. It is characterized by progressive hair loss, especially of scalp hair, and has distinctive patterns of loss in women versus men, but in both genders the central scalp is most severely affected. It often begins around puberty and is known to effect self-esteem and the individual's quality of life. In contrast to the high prevalence of AGA, approved therapeutic options are limited. In addition to the scarce pharmacologic treatments, there are numerous nonprescription products claimed to be effective in restoring hair in androgenetic alopecia.
[OBJECTIVES] The purpose of this paper is to review published medical and non-medical treatments for male and female AGA using the American College of Physicians evidence assessment methods. MEDLINE, EMBASE and Cochrane Library were searched for systematic reviews, randomized controlled trials, open studies, case reports and relevant studies of the treatment of male and female AGA. The relevant articles were classified according to grade and level of evidence.
[RESULTS] The medical treatments with the best level of evidence classification for efficacy and safety for male AGA are oral finasteride and topical minoxidil solution. For female AGA, topical minoxidil solution appears to be the most effective and safe treatment. The medical treatments corresponding to the next level of evidence quality are some commonly used therapeutic non-FDA-approved options including oral and topical anti-hormonal treatments. Surgical treatment of follicular unit hair transplantation is an option in cases that have failed medical treatment although there is high variation in outcomes.
[LIMITATIONS] Some articles, especially those concerning traditional herbs claimed to promote hair regrowth, were published in non-English, local journals.
[CONCLUSIONS] An assessment of the evidence quality of current publications indicates that oral finasteride (for men only) and topical minoxidil (for men and women) are the best treatments of AGA.
[OBJECTIVES] The purpose of this paper is to review published medical and non-medical treatments for male and female AGA using the American College of Physicians evidence assessment methods. MEDLINE, EMBASE and Cochrane Library were searched for systematic reviews, randomized controlled trials, open studies, case reports and relevant studies of the treatment of male and female AGA. The relevant articles were classified according to grade and level of evidence.
[RESULTS] The medical treatments with the best level of evidence classification for efficacy and safety for male AGA are oral finasteride and topical minoxidil solution. For female AGA, topical minoxidil solution appears to be the most effective and safe treatment. The medical treatments corresponding to the next level of evidence quality are some commonly used therapeutic non-FDA-approved options including oral and topical anti-hormonal treatments. Surgical treatment of follicular unit hair transplantation is an option in cases that have failed medical treatment although there is high variation in outcomes.
[LIMITATIONS] Some articles, especially those concerning traditional herbs claimed to promote hair regrowth, were published in non-English, local journals.
[CONCLUSIONS] An assessment of the evidence quality of current publications indicates that oral finasteride (for men only) and topical minoxidil (for men and women) are the best treatments of AGA.
【연구 목적】 전 세계적으로 흔한 만성 질환인 안드로겐 탈모증(Androgenetic alopecia, AGA)의 치료 옵션은 제한적이지만 다양한 비처방 제품이 시판되고 있어, 본 연구는 남성 및 여성 AGA에 대한 의학적이고 비의학적인 치료법의 증거 기반 효과를 체계적으로 평가하고자 한다.
APA 7
Varothai, S., & Bergfeld, W. F. (2014). Androgenetic alopecia: An evidence-based treatment update.. American journal of clinical dermatology, 15(3), 217-30. https://doi.org/10.1007/s40257-014-0077-5
Vancouver
Varothai S, Bergfeld WF. Androgenetic alopecia: an evidence-based treatment update. Amer. jour. clin. derm.. 2014;15(3):217-30. doi:10.1007/s40257-014-0077-5
AMA 11
Varothai S, Bergfeld WF. Androgenetic alopecia: an evidence-based treatment update. Amer. jour. clin. derm.. 2014;15(3):217-30. doi:10.1007/s40257-014-0077-5
Chicago
Varothai, S., and Bergfeld, W. F.. 2014. "Androgenetic alopecia: an evidence-based treatment update." American journal of clinical dermatology 15 (3): 217-30. https://doi.org/10.1007/s40257-014-0077-5
MLA 9
Varothai, S., and Bergfeld WF. "Androgenetic alopecia: an evidence-based treatment update." American journal of clinical dermatology, vol. 15, no. 3, 2014, pp. 217-30. doi:10.1007/s40257-014-0077-5.
PMID
24848508 ↗
추출된 의학 개체 (NER)
전체 NER 표 보기
| 유형 | 영어 표현 | 한국어 / 풀이 | UMLS CUI | 출처 | 등장 |
|---|---|---|---|---|---|
| 시술 | hair transplantation
|
모발이식 | dict | 1 | |
| 해부 | oral finasteride
|
scispacy | 1 | ||
| 해부 | oral
|
구강 | scispacy | 1 | |
| 해부 | herbs
|
약초 | scispacy | 1 | |
| 해부 | hair
|
모발 | scispacy | 1 | |
| 해부 | EMBASE
|
엠베이스(Embase) | scispacy | 1 | |
| 합병증 | scalp
|
두피 | scispacy | 1 | |
| 합병증 | androgenetic alopecia
|
안드로겐성 탈모 | scispacy | 1 | |
| 약물 | finasteride
|
피나스테리드 |
C0060389
finasteride
|
scispacy | 1 |
| 약물 | minoxidil
|
미녹시딜 |
C0026196
minoxidil
|
scispacy | 1 |
| 약물 | non-FDA-approved
|
scispacy | 1 | ||
| 약물 | [BACKGROUND] Androgenetic alopecia
|
scispacy | 1 | ||
| 질환 | follicular
|
모낭 | scispacy | 1 | |
| 질환 | Androgenetic alopecia
|
안드로겐성 탈모 |
C0162311
Androgenetic Alopecia
|
scispacy | 1 |
| 질환 | hair loss
|
탈모 |
C0002170
Alopecia
|
scispacy | 1 |
| 질환 | AGA
→ Androgenetic alopecia
|
안드로겐성 탈모(AGA) | scispacy | 1 | |
| 기타 | hair
|
모발 | scispacy | 1 | |
| 기타 | scalp hair
|
scispacy | 1 | ||
| 기타 | women
|
여성 | scispacy | 1 | |
| 기타 | men
|
남성 | scispacy | 1 | |
| 기타 | AGA
→ Androgenetic alopecia
|
안드로겐성 탈모(AGA) | scispacy | 1 | |
| 기타 | Cochrane Library
|
scispacy | 1 |
🏷️ 키워드 / MeSH 📖 같은 키워드 OA만
인용 관계
그래프 OA 노드: 8/8 (100%)
· 참조 0편 · 후속 8편
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함께 등장하는 도메인
이 논문이 속한 카테고리와 같은 논문에서 자주 함께 다뤄지는 카테고리들
🏷️ 같은 키워드 · 무료전문 — 이 논문 MeSH/keyword 기반
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