A Therapeutic Microneedle Patch Made from Hair-Derived Keratin for Promoting Hair Regrowth.
💡 한 문장 핵심
모발 유래 케라틴으로 제작된 모발 재성장 촉진용 치료적 마이크로니들 패치.
4/5 보강
TL;DR
It was demonstrated that this microneedle device integrated with mesenchymal stem cell (MSC)-derived exosomes and a small molecular drug, UK5099, could enhance the treatment efficiency at a reduced dosage, leading to promoted pigmentation and hair regrowth within 6 days through two rounds of administration in a mouse model.
📑 코퍼스 인용 관계
· 인용됨 21
📑 인용한 논문 (6) ▾
- A Scoping Review of Exosome Delivery Applications in Hair Loss. Cureus · 2025
- The Role of Mesenchymal Stem Cell-Derived Exosomes in Skin Regeneration, Tissue Repair, an… Advances in experimental medicine and biology · 2025
- Recent Advances in Drug Development for Hair Loss. International journal of molecular sciences · 2025
- Advances in the extracellular vesicles treatment of alopecia. Annals of medicine · 2025
- The Roles of Exosomes in Regulating Hair Follicle Growth. Clinical, cosmetic and investigational dermatology · 2024
- Dissolvable microneedles loaded ginsenoside Rg3 liposome: a transdermal delivery approach … Regenerative biomaterials · 2024
연도별 인용 (2019–2026) · 합계 291
OpenAlex 토픽 ·
Hair Growth and Disorders
Advancements in Transdermal Drug Delivery
Skin and Cellular Biology Research
Abstract 🌐 Abstract
Activating hair follicle stem cells (HFSCs) to promote hair follicle regrowth holds promise for hair loss therapy, while challenges still remain to develop a scenario that enables enhanced therapeutic efficiency and easy administration. Here we describe a detachable microneedle patch-mediated drug delivery system, mainly made from hair-derived keratin, for sustained delivery of HFSC activators. It was demonstrated that this microneedle device integrated with mesenchymal stem cell (MSC)-derived exosomes and a small molecular drug, UK5099, could enhance the treatment efficiency at a reduced dosage, leading to promoted pigmentation and hair regrowth within 6 days through two rounds of administration in a mouse model. This microneedle-based transdermal drug delivery approach shows augmented efficacy compared to the subcutaneous injection of exosomes and topical administration of UK5099.
It was demonstrated that this microneedle device integrated with mesenchymal stem cell (MSC)-derived exosomes and a small molecular drug, UK5099, could enhance the treatment efficiency at a reduced do
APA 7
Yang, G., Chen, Q., Wen, D., Chen, Z., Wang, J., Chen, G., Wang, Z., Zhang, X., Zhang, Y., Hu, Q., Zhang, L., & Gu, Z. (2019). A therapeutic microneedle patch made from hair-derived keratin for promoting hair regrowth.. ACS nano, 13(4), 4354-4360. https://doi.org/10.1021/acsnano.8b09573
Vancouver
Yang G, Chen Q, Wen D, Chen Z, Wang J, Chen G, et al. A Therapeutic Microneedle Patch Made from Hair-Derived Keratin for Promoting Hair Regrowth. ACS nano. 2019;13(4):4354-4360. doi:10.1021/acsnano.8b09573
AMA 11
Yang G, Chen Q, Wen D, Chen Z, Wang J, Chen G, et al. A Therapeutic Microneedle Patch Made from Hair-Derived Keratin for Promoting Hair Regrowth. ACS nano. 2019;13(4):4354-4360. doi:10.1021/acsnano.8b09573
Chicago
Yang, G., Chen, Q., Wen, D., Chen, Z., Wang, J., Chen, G., Wang, Z., Zhang, X., Zhang, Y., Hu, Q., and .... 2019. "A Therapeutic Microneedle Patch Made from Hair-Derived Keratin for Promoting Hair Regrowth." ACS nano 13 (4): 4354-4360. https://doi.org/10.1021/acsnano.8b09573
MLA 9
Yang, G., et al. "A Therapeutic Microneedle Patch Made from Hair-Derived Keratin for Promoting Hair Regrowth." ACS nano, vol. 13, no. 4, 2019, pp. 4354-4360. doi:10.1021/acsnano.8b09573.
PMID
30942567 ↗
추출된 의학 개체 (NER)
전체 NER 표 보기
| 유형 | 영어 표현 | 한국어 / 풀이 | UMLS CUI | 출처 | 등장 |
|---|---|---|---|---|---|
| 해부 | hair follicle
|
모낭 | dict | 2 | |
| 해부 | subcutaneous
|
피하조직 | dict | 1 | |
| 합병증 | pigmentation
|
색소침착 | dict | 1 |
🏷️ 키워드 / MeSH 📖 같은 키워드 OA만
인용 관계
그래프 OA 노드: 8/8 (100%)
· 참조 0편 · 후속 8편
이 논문을 인용한 후속 연구 20
- Dermal exosomes containing miR-218-5p promote hair regeneration by regulating β-catenin signaling.
- Sustained release of dermal papilla-derived extracellular vesicles from injectable microgel promotes…
- Hydrogel forming microneedles loaded with VEGF and Ritlecitinib/polyhydroxyalkanoates nanoparticles …
- Transdermal delivery of Minoxidil using HA-PLGA nanoparticles for the treatment in alopecia.
- The Roles of Exosomes in Regulating Hair Follicle Growth.
- Hair follicle-targeting drug delivery strategies for the management of hair follicle-associated diso…
- Bioinspired engineering ADSC nanovesicles thermosensitive hydrogel enhance autophagy of dermal papil…
- Effectiveness of Exosome Treatment in Androgenetic Alopecia: Outcomes of a Prospective Study.
- Recent Advances in Drug Development for Hair Loss.
- Duo-role Platelet-rich Plasma: temperature-induced fibrin gel and growth factors' reservoir for micr…
- Innovative Strategies for Hair Regrowth and Skin Visualization.
- Transdermal Composite Microneedle Composed of Mesoporous Iron Oxide Nanoraspberry and PVA for Androg…
- Application of Cell-Derived Extracellular Vesicles and Engineered Nanovesicles for Hair Growth: From…
- Promotion of Hair Regrowth by Transdermal Dissolvable Microneedles Loaded with Rapamycin and Epigall…
- A Scoping Review of Exosome Delivery Applications in Hair Loss.
- Hair Regeneration Methods Using Cells Derived from Human Hair Follicles and Challenges to Overcome.
- Application of extracellular vesicles from mesenchymal stem cells promotes hair growth by regulating…
- Dissolvable microneedles loaded ginsenoside Rg3 liposome: a transdermal delivery approach for alopec…
- Advances in the extracellular vesicles treatment of alopecia.
- The Role of Mesenchymal Stem Cell-Derived Exosomes in Skin Regeneration, Tissue Repair, and the Regu…
함께 등장하는 도메인
이 논문이 속한 카테고리와 같은 논문에서 자주 함께 다뤄지는 카테고리들
같은 제1저자의 인용 많은 논문 (5)
- Transdermal Drug Delivery for Hair Regrowth.
- Bioactive Poly(amino acid) Nanomaterials Potentiate Cancer Immunotherapy.
- Roles of Catecholamines and Inflammation in Endothelial Dysfunction: a Study Using Takotsubo Syndrome Patient-specific hiPSC-ECs.
- Influence of Tripterygium wilfordii Hook F and Caulis Sinomenii with traditional Chinese medicine directed drug delivery on CD3+, CD4+, CD8+ and joint function in rheumatoid arthritis patients.
- Rapid and Specific Detection of Gastric Cancer EVs Using a Cas12a-Powered Aptasensor with a Novel Targeting Aptamer.
🏷️ 같은 키워드 · 무료전문 — 이 논문 MeSH/keyword 기반
📖 비슷한 OA 논문 — 같은 카테고리, 무료 전문 가능
-
Alopecia areata.
TL;DRAlopecia areata is difficult to manage medically, but recent advances in understanding the molecular mechanisms have revealed new treatments and the possibility of remission in the…
-
Treatment options for androgenetic alopecia: Efficacy, side effects, compliance, financial considerations, and ethics.
TL;DRAlthough a variety of medical, surgical, light‐based and nutraceutical treatment options are available to slow or reverse the progression of AGA, it can be challenging to select ap…
-
Hair follicle immune privilege and its collapse in alopecia areata.
TL;DRA key goal for effective AA management is the re‐establishment of a functional HF IP, which will also provide superior protection from disease relapse, and may confer increased sus…
-
Alopecia areata: A multifactorial autoimmune condition.
TL;DRVarious genetic and environmental factors that cause autoimmunity are discussed and the immune mechanisms that lead to hair loss in alopecia areata patients are described.
-
Genome-wide meta-analysis in alopecia areata resolves HLA associations and reveals two new susceptibility loci.
TL;DRThe first meta-analysis of research on AA is performed by combining data from two genome-wide association studies (GWAS), and replication with supplemented ImmunoChip data for a to…