A Therapeutic Microneedle Patch Made from Hair-Derived Keratin for Promoting Hair Regrowth.
💡 한 문장 핵심
모발 유래 케라틴으로 제작된 모발 재성장 촉진용 치료적 마이크로니들 패치.
5/5 보강
TL;DR
It was demonstrated that this microneedle device integrated with mesenchymal stem cell (MSC)-derived exosomes and a small molecular drug, UK5099, could enhance the treatment efficiency at a reduced dosage, leading to promoted pigmentation and hair regrowth within 6 days through two rounds of administration in a mouse model.
📑 코퍼스 인용 관계
· 인용됨 21
📑 인용한 논문 (6) ▾
- A Scoping Review of Exosome Delivery Applications in Hair Loss. Cureus · 2025
- The Role of Mesenchymal Stem Cell-Derived Exosomes in Skin Regeneration, Tissue Repair, an… Advances in experimental medicine and biology · 2025
- Recent Advances in Drug Development for Hair Loss. International journal of molecular sciences · 2025
- Advances in the extracellular vesicles treatment of alopecia. Annals of medicine · 2025
- The Roles of Exosomes in Regulating Hair Follicle Growth. Clinical, cosmetic and investigational dermatology · 2024
- Dissolvable microneedles loaded ginsenoside Rg3 liposome: a transdermal delivery approach … Regenerative biomaterials · 2024
연도별 인용 (2019–2026) · 합계 291
OpenAlex 토픽 ·
Hair Growth and Disorders
Advancements in Transdermal Drug Delivery
Skin and Cellular Biology Research
🇰🇷 한글 요약 🌐 Abstract
【연구 목적】
모낭줄기세포(hair follicle stem cells, HFSCs)를 활성화해 탈모를 치료하려는 시도는 유망하지만, 치료 효율을 높이면서도 투여가 간편한 방법이 필요했습니다. 본 연구는 이 두 과제를 동시에 해결하는 약물전달 시스템 개발을 목표로 했습니다.
【방법】
모발에서 추출한 케라틴(keratin)으로 만든 분리형(detachable) 마이크로니들 패치(microneedle patch)에 중간엽줄기세포(mesenchymal stem cell) 유래 엑소좀(exosome)과 저분자 약물 UK5099를 탑재하여, 마우스 모델에 2회에 걸쳐 경피(transdermal) 투여했습니다.
【주요 결과】
이 마이크로니들 패치는 줄기세포 활성인자를 서서히 방출(sustained release)하여, 더 낮은 용량으로도 6일 이내에 색소침착(pigmentation)과 모발 재성장을 촉진했습니다. 엑소좀 피하주사나 UK5099 국소도포보다 우수한 효과를 보였습니다.
【임상적 시사점 (성형외과 의사 관점)】
모발 유래 케라틴 기반 마이크로니들은 탈모 치료에서 주사·도포 대비 통증과 용량을 줄이면서 효과를 높이는 자가투여형 옵션이 될 수 있습니다. 다만 아직 마우스 단계 연구로, 사람 대상 안전성·유효성 검증과 상용화까지는 추가 연구가 필요합니다.
Activating hair follicle stem cells (HFSCs) to promote hair follicle regrowth holds promise for hair loss therapy, while challenges still remain to develop a scenario that enables enhanced therapeutic efficiency and easy administration. Here we describe a detachable microneedle patch-mediated drug delivery system, mainly made from hair-derived keratin, for sustained delivery of HFSC activators. It was demonstrated that this microneedle device integrated with mesenchymal stem cell (MSC)-derived exosomes and a small molecular drug, UK5099, could enhance the treatment efficiency at a reduced dosage, leading to promoted pigmentation and hair regrowth within 6 days through two rounds of administration in a mouse model. This microneedle-based transdermal drug delivery approach shows augmented efficacy compared to the subcutaneous injection of exosomes and topical administration of UK5099.
【연구 목적】 모낭줄기세포(hair follicle stem cells, HFSCs)를 활성화해 탈모를 치료하려는 시도는 유망하지만, 치료 효율을 높이면서도 투여가 간편한 방법이 필요했습니다.
APA 7
Yang, G., Chen, Q., Wen, D., Chen, Z., Wang, J., Chen, G., Wang, Z., Zhang, X., Zhang, Y., Hu, Q., Zhang, L., & Gu, Z. (2019). A therapeutic microneedle patch made from hair-derived keratin for promoting hair regrowth.. ACS nano, 13(4), 4354-4360. https://doi.org/10.1021/acsnano.8b09573
Vancouver
Yang G, Chen Q, Wen D, Chen Z, Wang J, Chen G, et al. A Therapeutic Microneedle Patch Made from Hair-Derived Keratin for Promoting Hair Regrowth. ACS nano. 2019;13(4):4354-4360. doi:10.1021/acsnano.8b09573
AMA 11
Yang G, Chen Q, Wen D, Chen Z, Wang J, Chen G, et al. A Therapeutic Microneedle Patch Made from Hair-Derived Keratin for Promoting Hair Regrowth. ACS nano. 2019;13(4):4354-4360. doi:10.1021/acsnano.8b09573
Chicago
Yang, G., Chen, Q., Wen, D., Chen, Z., Wang, J., Chen, G., Wang, Z., Zhang, X., Zhang, Y., Hu, Q., and .... 2019. "A Therapeutic Microneedle Patch Made from Hair-Derived Keratin for Promoting Hair Regrowth." ACS nano 13 (4): 4354-4360. https://doi.org/10.1021/acsnano.8b09573
MLA 9
Yang, G., et al. "A Therapeutic Microneedle Patch Made from Hair-Derived Keratin for Promoting Hair Regrowth." ACS nano, vol. 13, no. 4, 2019, pp. 4354-4360. doi:10.1021/acsnano.8b09573.
PMID
30942567 ↗
추출된 의학 개체 (NER)
전체 NER 표 보기
| 유형 | 영어 표현 | 한국어 / 풀이 | UMLS CUI | 출처 | 등장 |
|---|---|---|---|---|---|
| 해부 | hair follicle
|
모낭 | dict | 2 | |
| 해부 | subcutaneous
|
피하조직 | dict | 1 | |
| 합병증 | pigmentation
|
색소침착 | dict | 1 |
🏷️ 키워드 / MeSH 📖 같은 키워드 OA만
인용 관계
그래프 OA 노드: 8/8 (100%)
· 참조 0편 · 후속 8편
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