Tofacitinib for the treatment of severe alopecia areata and variants: A study of 90 patients.
💡 한 문장 핵심
중증 원형탈모 및 변이형 치료를 위한 tofacitinib: 90명 환자 대상 연구.
5/5 보강
TL;DR
Tofacitinib should be considered for the treatment of severe AA, alopecia totalis, and alopECia universalis; tofacit inib dose response will be better defined by randomized controlled trials.
PICO 자동 추출 (휴리스틱, conf 2/4)
유사 논문P · Population 대상 환자/모집단
환자: AA experienced a higher percent change in SALT score than did patients with alopecia totalis or alopecia universalis (81
I · Intervention 중재 / 시술
추출되지 않음
C · Comparison 대조 / 비교
추출되지 않음
O · Outcome 결과 / 결론
[LIMITATIONS] The retrospective nature of the data, the relatively small number of patients, and lack of a control group are limitations. [CONCLUSION] Tofacitinib should be considered for the treatment of severe AA, alopecia totalis, and alopecia universalis; tofacitinib dose response will be better defined by randomized controlled trials.
📑 코퍼스 인용 관계
· 인용됨 96
📑 인용한 논문 (6) ▾
- Systemic Inflammation Marker Alterations in Severe Alopecia Areata Patients Treated with J… Journal of clinical medicine · 2026
- Long-Term Efficacy and Safety of Ritlecitinib in Adults and Adolescents with Alopecia Area… American journal of clinical dermatology · 2026
- Case Report: Successful treatment of pediatric alopecia universalis with ritlecitinib afte… Frontiers in medicine · 2025
- Efficacy of Oral Tofacitinib in Alopecia Areata, Alopecia Totalis, and Alopecia Universali… Cureus · 2025
- Alopecia Areata: Pathogenesis, Diagnosis, and Therapies. MedComm · 2025
- Exploring the Use of Topical Tofacitinib in Pediatric Alopecia Totalis. International journal of trichology · 2025
연도별 인용 (2016–2026) · 합계 334
OpenAlex 토픽 ·
Hair Growth and Disorders
Skin and Cellular Biology Research
Dermatology and Skin Diseases
🇰🇷 한글 요약 🌐 Abstract
【연구 목적】
야누스 키나아제(JAK) 1/3 억제제인 토파시티닙(tofacitinib)의 중증 원형 탈모증(alopecia areata, AA) 및 그 변이형(전두 탈모증 alopecia totalis, 전신 탈모증 alopecia universalis)에 대한 안전성과 유효성을 장기간에 걸쳐 평가하고자 하였다.
【방법】
두피 모발 소실이 40% 이상인 18세 이상 환자 90명을 대상으로 토파시티닙 치료의 후향적 분석을 시행하였다. 일차 평가지표는 치료 중 SALT(Severity of Alopecia Tool) 점수의 변화율이었다.
【주요 결과】
잠재적 반응군 65명(현 병력 10년 이하의 전두/전신 탈모증 또는 원형 탈모증) 중 77%가 임상적 반응을 보였고, 58%는 4~18개월 치료 동안 SALT 점수가 50% 이상 호전되었다. 원형 탈모증 환자는 전두/전신 탈모증 환자보다 더 큰 호전(81.9% vs 59.0%)을 보였으며, 중대한 이상반응은 없었다.
【임상적 시사점 (성형외과 의사 관점)】
모발이식(hair transplantation)이 어렵거나 부적합한 중증 자가면역성 탈모 환자에서 토파시티닙은 의뢰·병용 치료 옵션으로 고려할 만하며, 특히 이식 후 재발 위험이 높은 활동성 AA 환자의 사전 안정화에 유용할 수 있다. 다만 병력 10년 이내·전두/전신 탈모보다는 국소형 AA에서 반응률이 더 높다는 점, 그리고 면역억제제 사용에 따른 감염 모니터링이 필요하다는 점을 환자 상담 시 명확히 전달해야 한다.
[BACKGROUND] Alopecia areata (AA) is a common autoimmune disorder. There are no reliably effective therapies for AA.
[OBJECTIVE] We sought to evaluate the safety and efficacy of the Janus kinase 1/3 inhibitor, tofacitinib, in a series of patients over an extended period of time.
[METHODS] This is a retrospective study of patients age 18 years or older with AA with at least 40% scalp hair loss treated with tofacitinib. The primary end point was the percent change in Severity of Alopecia Tool (SALT) score during treatment.
[RESULTS] Ninety patients met inclusion criteria. Of 65 potential responders to therapy, defined as those with alopecia totalis or alopecia universalis with duration of current episode of disease of 10 years or less or alopecia areata, 77% achieved a clinical response, with 58% of patients achieving greater than 50% change in SALT score over 4 to 18 months of treatment. Patients with AA experienced a higher percent change in SALT score than did patients with alopecia totalis or alopecia universalis (81.9% vs 59.0%). Tofacitinib was well tolerated, and there were no serious adverse events.
[LIMITATIONS] The retrospective nature of the data, the relatively small number of patients, and lack of a control group are limitations.
[CONCLUSION] Tofacitinib should be considered for the treatment of severe AA, alopecia totalis, and alopecia universalis; tofacitinib dose response will be better defined by randomized controlled trials.
[OBJECTIVE] We sought to evaluate the safety and efficacy of the Janus kinase 1/3 inhibitor, tofacitinib, in a series of patients over an extended period of time.
[METHODS] This is a retrospective study of patients age 18 years or older with AA with at least 40% scalp hair loss treated with tofacitinib. The primary end point was the percent change in Severity of Alopecia Tool (SALT) score during treatment.
[RESULTS] Ninety patients met inclusion criteria. Of 65 potential responders to therapy, defined as those with alopecia totalis or alopecia universalis with duration of current episode of disease of 10 years or less or alopecia areata, 77% achieved a clinical response, with 58% of patients achieving greater than 50% change in SALT score over 4 to 18 months of treatment. Patients with AA experienced a higher percent change in SALT score than did patients with alopecia totalis or alopecia universalis (81.9% vs 59.0%). Tofacitinib was well tolerated, and there were no serious adverse events.
[LIMITATIONS] The retrospective nature of the data, the relatively small number of patients, and lack of a control group are limitations.
[CONCLUSION] Tofacitinib should be considered for the treatment of severe AA, alopecia totalis, and alopecia universalis; tofacitinib dose response will be better defined by randomized controlled trials.
【연구 목적】 야누스 키나아제(JAK) 1/3 억제제인 토파시티닙(tofacitinib)의 중증 원형 탈모증(alopecia areata, AA) 및 그 변이형(전두 탈모증 alopecia totalis, 전신 탈모증 alopecia universalis)에 대한 안전성과 유효성을 장기간에 걸쳐 평가하고자 하였다.
APA 7
Liu, L. Y., Craiglow, B. G., Dai, F., & King, B. A. (2017). Tofacitinib for the treatment of severe alopecia areata and variants: A study of 90 patients.. Journal of the American Academy of Dermatology, 76(1), 22-28. https://doi.org/10.1016/j.jaad.2016.09.007
Vancouver
Liu LY, Craiglow BG, Dai F, King BA. Tofacitinib for the treatment of severe alopecia areata and variants: A study of 90 patients. Jour. Amer. Acad. Derm.. 2017;76(1):22-28. doi:10.1016/j.jaad.2016.09.007
AMA 11
Liu LY, Craiglow BG, Dai F, King BA. Tofacitinib for the treatment of severe alopecia areata and variants: A study of 90 patients. Jour. Amer. Acad. Derm.. 2017;76(1):22-28. doi:10.1016/j.jaad.2016.09.007
Chicago
Liu, L. Y., Craiglow, B. G., Dai, F., and King, B. A.. 2017. "Tofacitinib for the treatment of severe alopecia areata and variants: A study of 90 patients." Journal of the American Academy of Dermatology 76 (1): 22-28. https://doi.org/10.1016/j.jaad.2016.09.007
MLA 9
Liu, L. Y., et al. "Tofacitinib for the treatment of severe alopecia areata and variants: A study of 90 patients." Journal of the American Academy of Dermatology, vol. 76, no. 1, 2017, pp. 22-28. doi:10.1016/j.jaad.2016.09.007.
PMID
27816293 ↗
추출된 의학 개체 (NER)
전체 NER 표 보기
| 유형 | 영어 표현 | 한국어 / 풀이 | UMLS CUI | 출처 | 등장 |
|---|---|---|---|---|---|
| 질환 | alopecia areata
|
원형 탈모증 | dict | 3 | |
| 질환 | alopecia areata
|
원형 탈모증 | dict | 3 | |
| 질환 | alopecia areata
|
원형 탈모증 | dict | 3 | |
| 해부 | scalp
|
두피 | dict | 1 | |
| 해부 | scalp
|
두피 | dict | 1 | |
| 해부 | scalp
|
두피 | dict | 1 |
🏷️ 키워드 / MeSH 📖 같은 키워드 OA만
인용 관계
그래프 OA 노드: 5/8 (63%)
· 참조 0편 · 후속 5편
이 논문을 인용한 후속 연구 20
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- Phase 2a randomized clinical trial of dupilumab (anti-IL-4Rα) for alopecia areata patients.
- The Alopecia Areata Investigator Global Assessment scale: a measure for evaluating clinically meanin…
- JAK inhibitors in dermatology: The promise of a new drug class.
- Alopecia Areata: Current Treatments and New Directions.
- The Changing Landscape of Alopecia Areata: The Therapeutic Paradigm.
- JAK Inhibitors for Treatment of Alopecia Areata.
- Immune modulation of hair follicle regeneration.
- Baricitinib for the Treatment of Alopecia Areata.
- A Comprehensive Literature Review of JAK Inhibitors in Treatment of Alopecia Areata.
- The Effect of JAK Inhibitor on the Survival, Anagen Re-Entry, and Hair Follicle Immune Privilege Res…
- Tofacitinib for the treatment of lichen planopilaris: A case series.
- The current state of knowledge of the immune ecosystem in alopecia areata.
- Evaluating the Therapeutic Potential of Ritlecitinib for the Treatment of Alopecia Areata.
- Development of the Scalp Hair Assessment PRO™ measure for alopecia areata.
- New and Emerging Therapies for Alopecia Areata.
같은 제1저자의 인용 많은 논문 (5)
- Health-related quality of life (HRQoL) among patients with alopecia areata (AA): A systematic review.
- Alopecia areata is associated with impaired health-related quality of life: A survey of affected adults and children and their families.
- Tofacitinib 2% ointment, a topical Janus kinase inhibitor, for the treatment of alopecia areata: A pilot study of 10 patients.
- Ruxolitinib for the treatment of severe alopecia areata.
- Tofacitinib for the Treatment of Severe Alopecia Areata in Adults and Adolescents.
🏷️ 같은 키워드 · 무료전문 — 이 논문 MeSH/keyword 기반
- 피나스테리드가 전립선암 발생에 미치는 영향.
- COVID-19의 50가지 이상의 장기 후유증: 체계적 문헌고찰 및 메타분석.
- 양성 전립선 비대증의 임상적 진행에 대한 doxazosin, finasteride 및 병용 요법의 장기 효과.
- 양성 전립선 비대증 환자에서 finasteride의 효과. The Finasteride Study Group.
- 양성 전립선 비대증 남성에서 급성 요폐의 위험과 수술적 치료 필요성에 대한 finasteride의 효과. Finasteride Long-Term Efficacy and Safety Study Group.
- 원형 탈모에 대한 전장유전체 연관성 연구는 선천면역과 적응면역 모두의 관여를 시사한다.
📖 비슷한 OA 논문 — 같은 카테고리, 무료 전문 가능
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Alopecia areata.
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