Alopecia areata: a review of disease pathogenesis.
💡 한 문장 핵심
원형탈모: 질환 병인에 관한 고찰.
5/5 보강
TL;DR
Alopecia areata is a disorder that results in nonscarring hair loss, and the psychological impact can be significant, leading to feelings of depression and social isolation.
📑 코퍼스 인용 관계
· 인용됨 93
📑 인용한 논문 (6) ▾
- The Evolving Global Burden of Alopecia Areata in Young Adults: High-Income Nations Bear th… Annals of dermatology · 2026
- Systemic Inflammation Marker Alterations in Severe Alopecia Areata Patients Treated with J… Journal of clinical medicine · 2026
- Efficacy of Intralesional Triamcinolone Acetonide Combined With Cryotherapy Compared to In… Journal of cosmetic dermatology · 2026
- Stem cell-based therapies for alopecia areata: a narrative review. Stem cell research & therapy · 2026
- Meta-Analysis of Gene Expression Reveals the Core Transcriptomic Profile of Lesional Scalp… Dermatology and therapy · 2025
- Discontinuation and restart of Janus kinase inhibitors due to pregnancy in alopecia areata… International journal of women's dermatology · 2025
연도별 인용 (2018–2026) · 합계 279
OpenAlex 토픽 ·
Hair Growth and Disorders
Immune Cell Function and Interaction
Dermatology and Skin Diseases
🇰🇷 한글 요약 🌐 Abstract
【연구 목적】
원형 탈모증(alopecia areata)의 병인 기전에 대한 최근 연구를 서술적으로 고찰하여, 자가면역 반응이 모낭(hair follicle)에 어떻게 작용하는지 정리하고자 함.
【방법】
MEDLINE과 Scopus 데이터베이스에서 원형 탈모증 관련 문헌을 검색하였으며, 특히 병인 기전에 초점을 맞춘 내러티브 리뷰(narrative review)로 분석함.
【주요 결과】
원형 탈모증은 모낭 면역특권(immune privilege) 붕괴로 인한 자가면역 질환으로, 모낭 환경 스트레스에 의한 항원 제시 또는 중추 면역계 이상조절(AIRE 유전자 관련)이 원인으로 제시됨. 형질세포양 수지상세포(plasmacytoid dendritic cell), 자연살해세포(NK cell), T세포와 인터페론-γ, 인터루킨-15, MICA, NKG2D 등 핵심 분자가 자가면역 과정에 관여함.
【임상적 시사점 (성형외과 의사 관점)】
원형 탈모증은 모낭 자체가 파괴되지 않는 비반흔성 탈모(nonscarring alopecia)이므로 모발이식(hair transplantation)보다 면역억제 치료가 1차 선택이며, 활동성 병변에서는 모발이식 시 이식모도 자가면역 공격 대상이 될 수 있어 신중해야 함. 재발률이 높고 우울감·사회적 고립 등 심리적 영향이 크므로 환자 상담 시 현실적 기대치 설정과 정신건강 측면의 배려가 필요함.
[BACKGROUND] Alopecia areata is a disorder that results in nonscarring hair loss. The psychological impact can be significant, leading to feelings of depression and social isolation. Objectives In this article, we seek to review the pathophysiological mechanisms proposed in recent years in a narrative fashion.
[METHODS] We searched MEDLINE and Scopus for articles related to alopecia areata, with a particular emphasis on its pathogenesis.
[RESULTS] The main theory of alopecia areata pathogenesis is that it is an autoimmune phenomenon resulting from a disruption in hair follicle immune privilege. What causes this breakdown is an issue of debate. Some believe that a stressed hair follicle environment triggers antigen presentation, while others blame a dysregulation in the central immune system entangling the follicles. Evidence for the latter theory is provided by animal studies, as well investigations around the AIRE gene. Different immune-cell lines including plasmacytoid dendritic cells, natural killer cells and T cells, along with key molecules such as interferon-γ, interleukin-15, MICA and NKG2D, have been identified as contributing to the autoimmune process.
[CONCLUSIONS] Alopecia areata remains incurable, although it has been studied for years. Available treatment options at best are beneficial for milder cases, and the rate of relapse is high. Understanding the exact mechanisms of hair loss in alopecia areata is therefore of utmost importance to help identify potential therapeutic targets.
[METHODS] We searched MEDLINE and Scopus for articles related to alopecia areata, with a particular emphasis on its pathogenesis.
[RESULTS] The main theory of alopecia areata pathogenesis is that it is an autoimmune phenomenon resulting from a disruption in hair follicle immune privilege. What causes this breakdown is an issue of debate. Some believe that a stressed hair follicle environment triggers antigen presentation, while others blame a dysregulation in the central immune system entangling the follicles. Evidence for the latter theory is provided by animal studies, as well investigations around the AIRE gene. Different immune-cell lines including plasmacytoid dendritic cells, natural killer cells and T cells, along with key molecules such as interferon-γ, interleukin-15, MICA and NKG2D, have been identified as contributing to the autoimmune process.
[CONCLUSIONS] Alopecia areata remains incurable, although it has been studied for years. Available treatment options at best are beneficial for milder cases, and the rate of relapse is high. Understanding the exact mechanisms of hair loss in alopecia areata is therefore of utmost importance to help identify potential therapeutic targets.
【연구 목적】 원형 탈모증(alopecia areata)의 병인 기전에 대한 최근 연구를 서술적으로 고찰하여, 자가면역 반응이 모낭(hair follicle)에 어떻게 작용하는지 정리하고자 함.
APA 7
Rajabi, F., Drake, L. A., Senna, M. M., & Rezaei, N. (2018). Alopecia areata: A review of disease pathogenesis.. The British journal of dermatology, 179(5), 1033-1048. https://doi.org/10.1111/bjd.16808
Vancouver
Rajabi F, Drake LA, Senna MM, Rezaei N. Alopecia areata: a review of disease pathogenesis. Brit. jour. derm.. 2018;179(5):1033-1048. doi:10.1111/bjd.16808
AMA 11
Rajabi F, Drake LA, Senna MM, Rezaei N. Alopecia areata: a review of disease pathogenesis. Brit. jour. derm.. 2018;179(5):1033-1048. doi:10.1111/bjd.16808
Chicago
Rajabi, F., Drake, L. A., Senna, M. M., and Rezaei, N.. 2018. "Alopecia areata: a review of disease pathogenesis." The British journal of dermatology 179 (5): 1033-1048. https://doi.org/10.1111/bjd.16808
MLA 9
Rajabi, F., et al. "Alopecia areata: a review of disease pathogenesis." The British journal of dermatology, vol. 179, no. 5, 2018, pp. 1033-1048. doi:10.1111/bjd.16808.
PMID
29791718 ↗
추출된 의학 개체 (NER)
전체 NER 표 보기
| 유형 | 영어 표현 | 한국어 / 풀이 | UMLS CUI | 출처 | 등장 |
|---|---|---|---|---|---|
| 질환 | alopecia areata
|
원형 탈모증 | dict | 6 | |
| 질환 | alopecia areata
|
원형 탈모증 | dict | 6 | |
| 해부 | hair follicle
|
모낭 | dict | 2 | |
| 해부 | hair follicle
|
모낭 | dict | 2 | |
| 해부 | hair follicle
|
모낭 | dict | 2 |
🏷️ 키워드 / MeSH 📖 같은 키워드 OA만
- Alopecia Areata
- Animals
- Autoimmune Diseases
- Dendritic Cells
- Disease Models
- Animal
- Hair Follicle
- Histocompatibility Antigens Class I
- Humans
- Immune Privilege
- Immunologic Factors
- Interferon-gamma
- Interleukin-15
- Keratinocytes
- Killer Cells
- Natural
- NK Cell Lectin-Like Receptor Subfamily K
- Recurrence
- T-Lymphocytes
- Transcription Factors
- Treatment Outcome
- AIRE Protein
인용 관계
그래프 OA 노드: 6/8 (75%)
· 참조 0편 · 후속 6편
이 논문을 인용한 후속 연구 20
- Alopecia Areata: an Update on Etiopathogenesis, Diagnosis, and Management.
- Lifestyle Factors Involved in the Pathogenesis of Alopecia Areata.
- The Role of Serum Th1, Th2, and Th17 Cytokines in Patients with Alopecia Areata: Clinical Implicatio…
- The epidemiology of alopecia areata: a population-based cohort study in UK primary care.
- Comorbid Conditions Associated with Alopecia Areata: A Systematic Review and Meta-analysis.
- Alopecia Areata: An Autoimmune Disease of Multiple Players.
- Psychological Profile and Quality of Life of Patients with Alopecia Areata.
- Deciphering the molecular mechanisms of stem cell dynamics in hair follicle regeneration.
- Comorbidities in Androgenetic Alopecia: A Comprehensive Review.
- Novel potential therapeutic targets of alopecia areata.
- Scalp biomarkers during dupilumab treatment support Th2 pathway pathogenicity in alopecia areata.
- Prevalence and Risk Factors Associated with the Occurrence of Autoimmune Diseases in Patients with A…
- Deciphering the Complex Immunopathogenesis of Alopecia Areata.
- Alopecia Areata: A Review of the Role of Oxidative Stress, Possible Biomarkers, and Potential Novel …
- How Our Microbiome Influences the Pathogenesis of Alopecia Areata.
- Recent Advances in Understanding of the Etiopathogenesis, Diagnosis, and Management of Hair Loss Dis…
- Hair Follicle Melanocytes Initiate Autoimmunity in Alopecia Areata: a Trigger Point.
- Evaluation of the level of serum Interleukins (IL-2, IL-4, IL-15 andIL-17) and its relationship with…
- Alopecia Areata: Pathogenesis, Diagnosis, and Therapies.
- Clinical and Genetic Aspects of Alopecia Areata: A Cutting Edge Review.
같은 제1저자의 인용 많은 논문 (4)
🏷️ 같은 키워드 · 무료전문 — 이 논문 MeSH/keyword 기반
📖 비슷한 OA 논문 — 같은 카테고리, 무료 전문 가능
-
Alopecia areata.
TL;DRAlopecia areata is difficult to manage medically, but recent advances in understanding the molecular mechanisms have revealed new treatments and the possibility of remission in the…
-
Epidemiology and burden of alopecia areata: a systematic review.
TL;DRAA is the most prevalent autoimmune disorder and the second most prevalent hair loss disorder after androgenetic alopecia, and the lifetime risk in the global population is approxi…
-
Two Phase 3 Trials of Baricitinib for Alopecia Areata.
TL;DRIn two phase 3 trials involving patients with severe alopecia areata, oral baricitinib was superior to placebo with respect to hair regrowth at 36 weeks.
-
Treatment options for androgenetic alopecia: Efficacy, side effects, compliance, financial considerations, and ethics.
TL;DRAlthough a variety of medical, surgical, light‐based and nutraceutical treatment options are available to slow or reverse the progression of AGA, it can be challenging to select ap…
-
Hair follicle immune privilege and its collapse in alopecia areata.
TL;DRA key goal for effective AA management is the re‐establishment of a functional HF IP, which will also provide superior protection from disease relapse, and may confer increased sus…