본문으로 건너뛰기
← 뒤로

Global multi-ancestry genetic study elucidates genes and biological pathways associated with thyroid cancer and benign thyroid diseases.

메타분석 1/5 보강
medRxiv : the preprint server for health sciences 📖 저널 OA 100% 2023: 3/3 OA 2024: 5/5 OA 2025: 64/64 OA 2026: 48/48 OA 2023~2026 2025
Retraction 확인
출처

White SL, Brasher MS, Pattee J, Zhou W, Chapman S, Jee YH, Bell CC, Jamil TL, Barrio M, Hirbo J, Cox NJ, Straub P, Namba S, Bertucci-Richter E, Guare L, EdrisMohammed A, Morris S, Mulford AJ, Zhang H, Fennessy B, Tobin MD, Chen J, Williams AT, John C, van Heel DA, Mathur R, Finer S, Moksnes MR, Brumpton B, Åsvold BO, Peculis R, Rovite V, Konrade I, Wang Y, Crooks K, Chavan S, Fisher MJ, Rafaels N, Lin M, Shortt J, Sanders AR, Whiteman D, MacGregor S, Medland S, Thorsteinsdóttir U, Stefánsson K, Karaderi T, Egan KM, Bocklage T, McCrary HC, Riedlingeer G, Salhia B, Shriver C, Phan MD, Farlow JL, Edge S, Kaur V, Churchman M, Rounbehler RJ, Brock PL, Ringel MD, Pividori M, Schweppe R, Raeburn CD, Walters R, Chen Z, Li L, Matsuda K, Okada Y, Zoellner S, Verma A, Preuss M, Kenny E, Hendricks A, Fishbein L, Kraft P, Daly M, Neale B, Martin A, Cole JB, Haugen BR, Gignoux CR, Pozdeyev N

📝 환자 설명용 한 줄

Thyroid diseases are common and highly heritable.

🔬 핵심 임상 통계 (초록에서 자동 추출 — 원문 검증 권장)
  • 연구 설계 Meta-analysis

이 논문을 인용하기

↓ .bib ↓ .ris
APA White SL, Brasher MS, et al. (2025). Global multi-ancestry genetic study elucidates genes and biological pathways associated with thyroid cancer and benign thyroid diseases.. medRxiv : the preprint server for health sciences. https://doi.org/10.1101/2025.05.15.25327513
MLA White SL, et al.. "Global multi-ancestry genetic study elucidates genes and biological pathways associated with thyroid cancer and benign thyroid diseases.." medRxiv : the preprint server for health sciences, 2025.
PMID 40463558 ↗

Abstract

Thyroid diseases are common and highly heritable. Under the Global Biobank Meta-analysis Initiative, we performed a meta-analysis of genome-wide association studies from 19 biobanks for five thyroid diseases: thyroid cancer, benign nodular goiter, Graves' disease, lymphocytic thyroiditis, and primary hypothyroidism. We analyzed genetic association data from ~2.9 million genomes and identified 235 known and 501 novel independent variants significantly linked to thyroid diseases. We discovered genetic correlations between thyroid cancer, benign nodular goiter, and autoimmune thyroid diseases ( =0.21-0.97). Telomere maintenance genes contribute to benign and malignant thyroid nodular disease risk, whereas cell cycle, DNA repair, and DNA damage response genes are predominantly associated with thyroid cancer. We proposed a paradigm explaining genetic predisposition to benign and malignant thyroid nodules. We evaluated thyroid cancer polygenic risk scores (PRS) for clinical applications in thyroid cancer diagnosis. We found PRS associations with thyroid cancer risk features: multifocality, lymph node metastases, and extranodal extension.

같은 제1저자의 인용 많은 논문 (3)

🟢 PMC 전문 열기