Effect of ART1 on the efficacy of oxaliplatin in colorectal cancer under high-cholesterol conditions.
1/5 보강
The growth of colorectal cancer (CRC) can be affected by cholesterol (CHO), which may inhibit the efficacy of oxaliplatin (OXA).
APA
Chen X, Zhang S, et al. (2025). Effect of ART1 on the efficacy of oxaliplatin in colorectal cancer under high-cholesterol conditions.. Histology and histopathology, 25023. https://doi.org/10.14670/HH-25-023
MLA
Chen X, et al.. "Effect of ART1 on the efficacy of oxaliplatin in colorectal cancer under high-cholesterol conditions.." Histology and histopathology, 2025, pp. 25023.
PMID
41346334
Abstract
The growth of colorectal cancer (CRC) can be affected by cholesterol (CHO), which may inhibit the efficacy of oxaliplatin (OXA). A high-fat diet can upregulate phosphorylation by sphingosine kinase 1 (SPHK1)/sphingosine-1-phosphate (S1P)/sphingosine 1-phosphate receptor 1 (S1PR1) and promote tumour cell proliferation. Moreover, S1P activates signal transducer and activator of transcription 3 (STAT3), which plays a critical role in tumour cell proliferation. Knockdown of arginine-specific single ADP ribosyltransferase 1 (ART1) can delay the growth of CRC and promote the inhibitory effect of OXA on CRC cell proliferation. Consequently, in a high-CHO environment, this study aims to investigate the impact of ART1 knockdown in CRC cells treated with OXA and on the growth of transplanted tumours in mice .
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