Impact of Narrow-band Imaging on Sessile Serrated Lesion Miss Rate: A Multicenter Randomized Tandem Colonoscopy Trial.
1/5 보강
ℹ️ 이 논문은 무료 전문이 아직 없습니다. 코퍼스 전체의 43.6%는 무료 가능 (통계 →) · 🏥 기관 EZproxy로 시도
[BACKGROUND & AIMS] Sessile serrated lesions (SSLs) are precursors to post-colonoscopy colorectal cancer but are frequently missed because of their subtle morphology.
- p-value P = .003
- p-value P < .001
APA
Wei J, Zhang S, et al. (2026). Impact of Narrow-band Imaging on Sessile Serrated Lesion Miss Rate: A Multicenter Randomized Tandem Colonoscopy Trial.. Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association. https://doi.org/10.1016/j.cgh.2026.01.027
MLA
Wei J, et al.. "Impact of Narrow-band Imaging on Sessile Serrated Lesion Miss Rate: A Multicenter Randomized Tandem Colonoscopy Trial.." Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association, 2026.
PMID
41638419 ↗
Abstract 한글 요약
[BACKGROUND & AIMS] Sessile serrated lesions (SSLs) are precursors to post-colonoscopy colorectal cancer but are frequently missed because of their subtle morphology. Previous studies have reported the effectiveness of narrow-band imaging (NBI) for detecting colorectal adenomas, but its value for detecting SSLs remains unclear. This study aimed to determine whether NBI reduces the SSL miss rate (SSLMR).
[METHODS] This multicenter, randomized tandem trial was conducted in a colorectal cancer screening population across 15 endoscopy centers. The participants were randomly assigned to NBI-first or white light imaging-first (WLI-first) colonoscopy, followed by a second examination using the alternate modality. The primary outcome was the SSLMR, and secondary outcomes included the proximal serrated polyp miss rate, adenoma miss rate, and changes in surveillance intervals.
[RESULTS] NBI significantly reduced the SSLMR compared with WLI (17.5% vs 43.6%; P = .003), with consistent decreasing trends in subgroups stratified by location, sex, age, and other variables. The NBI-first group also had lower miss rates for proximal serrated lesions (19.3% vs 40.7%; P < .001) and adenomas (20.1% vs 29.5%; P = .002). However, the detection rates of adenomas and SSLs did not significantly differ between the 2 groups. NBI was the only independent factor associated with a reduced SSLMR in a multivariate regression model (odds ratio, 0.24) and increased the proportion of individuals recommended for intensive surveillance (11.8% vs 6.0%; P = .003).
[CONCLUSIONS] NBI significantly reduces the miss rates of SSLs, proximal serrated lesions, and adenomas without reducing that of advanced SSLs.
[CLINICALTRIALS] gov, Number: NCT05684328).
[METHODS] This multicenter, randomized tandem trial was conducted in a colorectal cancer screening population across 15 endoscopy centers. The participants were randomly assigned to NBI-first or white light imaging-first (WLI-first) colonoscopy, followed by a second examination using the alternate modality. The primary outcome was the SSLMR, and secondary outcomes included the proximal serrated polyp miss rate, adenoma miss rate, and changes in surveillance intervals.
[RESULTS] NBI significantly reduced the SSLMR compared with WLI (17.5% vs 43.6%; P = .003), with consistent decreasing trends in subgroups stratified by location, sex, age, and other variables. The NBI-first group also had lower miss rates for proximal serrated lesions (19.3% vs 40.7%; P < .001) and adenomas (20.1% vs 29.5%; P = .002). However, the detection rates of adenomas and SSLs did not significantly differ between the 2 groups. NBI was the only independent factor associated with a reduced SSLMR in a multivariate regression model (odds ratio, 0.24) and increased the proportion of individuals recommended for intensive surveillance (11.8% vs 6.0%; P = .003).
[CONCLUSIONS] NBI significantly reduces the miss rates of SSLs, proximal serrated lesions, and adenomas without reducing that of advanced SSLs.
[CLINICALTRIALS] gov, Number: NCT05684328).
🏷️ 키워드 / MeSH 📖 같은 키워드 OA만
같은 제1저자의 인용 많은 논문 (5)
- Revision Rhinoplasty in Asians.
- [Endoscopic characteristics of primary gastric lymphoma and prediction of treatment response].
- Efficacy of hyperthermic intraperitoneal chemotherapy in advanced ovarian cancer: a bibliometric analysis and updated meta-analysis.
- Toripalimab in patients with previously treated advanced upper tract urothelial carcinoma: a subgroup analysis of the phase II POLARIS-03 trial.
- Phase 2 multicenter maintenance study of golidocitinib, A JAK1 selective inhibitor, in patients with peripheral T cell lymphomas after first-line systemic therapy (JACKPOT26).
🏷️ 같은 키워드 · 무료전문 — 이 논문 MeSH/keyword 기반
- Copper-enriched zinc peroxides induced cuproptosis through concurrent metabolic and oxidative dysregulation for boosting immunotherapy in colorectal cancer.
- Editorial: Altered metabolic traits in gastro-intestinal tract cancers, volume II.
- Macrophage deficiency discordantly regulated tumor growth and metastasis through increased thrombospondin-1 production.
- Time-Resolved Oxygen Dynamics Reveals Redox-Selective Apoptosis Induced by Cold Atmospheric Plasma in HT-29 Colorectal Cancer Cells.
- System-Wide Implementation of Colorectal Cancer Screening in a Value-Based Care Setting.
- NG25 Enhances Anti-Tumor Immunity in -Mutant Colorectal Cancer.