Development and external validation of a novel online calculator for predicting long-term survival following radical hepatectomy in patients with BCLC stage 0/A hepatocellular carcinoma and clinically significant portal hypertension.
2/5 보강
PICO 자동 추출 (휴리스틱, conf 3/4)
유사 논문P · Population 대상 환자/모집단
환자: hepatocellular carcinoma (HCC) and clinically significant portal hypertension (CSPH) experience a poorer prognosis following hepatectomy (Hx)
I · Intervention 중재 / 시술
curative Hx at 12 medical centers between 2015 and 2020
C · Comparison 대조 / 비교
추출되지 않음
O · Outcome 결과 / 결론
Based on the nomogram, an online calculator was developed for individualized assessment of risk level and survival outcomes. [CONCLUSION] Based on multi-center data, an accessible online calculator was developed to individually forecast the survival prognosis of patients with BCLC stage 0/A HCC and CSPH undergoing Hx.
OpenAlex 토픽 ·
Hepatocellular Carcinoma Treatment and Prognosis
Cholangiocarcinoma and Gallbladder Cancer Studies
Intraperitoneal and Appendiceal Malignancies
[BACKGROUND] Patients with hepatocellular carcinoma (HCC) and clinically significant portal hypertension (CSPH) experience a poorer prognosis following hepatectomy (Hx).
- 표본수 (n) 370
- p-value P < 0.05
APA
Tianyin Shao, Hanlong Hu, et al. (2026). Development and external validation of a novel online calculator for predicting long-term survival following radical hepatectomy in patients with BCLC stage 0/A hepatocellular carcinoma and clinically significant portal hypertension.. European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology, 52(6), 111795. https://doi.org/10.1016/j.ejso.2026.111795
MLA
Tianyin Shao, et al.. "Development and external validation of a novel online calculator for predicting long-term survival following radical hepatectomy in patients with BCLC stage 0/A hepatocellular carcinoma and clinically significant portal hypertension.." European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology, vol. 52, no. 6, 2026, pp. 111795.
PMID
42019372
Abstract
[BACKGROUND] Patients with hepatocellular carcinoma (HCC) and clinically significant portal hypertension (CSPH) experience a poorer prognosis following hepatectomy (Hx). This study aimed to develop a calculator to estimate the survival outcomes of the cohort.
[METHODS] This study collected data from patients with BCLC stage 0/A HCC and CSPH who underwent curative Hx at 12 medical centers between 2015 and 2020. Prognostic factors for overall survival (OS) were identified using the Cox proportional hazards model. The performance of the nomogram was primarily assessed through the concordance index (C-index), compared with the Model of End-Stage Liver Disease-alpha-fetoprotein-tumor burden (MELD-AFP-TBS) and Chinese University Prognostic Index (CUPI).
[RESULTS] The patients were split into training (n = 370) and validation (n = 157) cohorts, with well-balanced baseline characteristics (all P > 0.05). The AUC values of the nomogram for 3- and 5-year OS were 0.776 and 0.712 in the training cohort, and 0.695 and 0.732 in the validation cohort. The C-index values for the nomogram were significantly improved (training cohort: vs. MELD-AFP-TBS, 0.148 [0.091-0.204]; vs. CUPI, 0.184 [0.134-0.234]; validation cohort: vs. MELD-AFP-TBS, 0.146 [0.054-0.238]; vs. CUPI, 0.140 [0.050-0.230]; all P < 0.05). Based on the nomogram, an online calculator was developed for individualized assessment of risk level and survival outcomes.
[CONCLUSION] Based on multi-center data, an accessible online calculator was developed to individually forecast the survival prognosis of patients with BCLC stage 0/A HCC and CSPH undergoing Hx.
[METHODS] This study collected data from patients with BCLC stage 0/A HCC and CSPH who underwent curative Hx at 12 medical centers between 2015 and 2020. Prognostic factors for overall survival (OS) were identified using the Cox proportional hazards model. The performance of the nomogram was primarily assessed through the concordance index (C-index), compared with the Model of End-Stage Liver Disease-alpha-fetoprotein-tumor burden (MELD-AFP-TBS) and Chinese University Prognostic Index (CUPI).
[RESULTS] The patients were split into training (n = 370) and validation (n = 157) cohorts, with well-balanced baseline characteristics (all P > 0.05). The AUC values of the nomogram for 3- and 5-year OS were 0.776 and 0.712 in the training cohort, and 0.695 and 0.732 in the validation cohort. The C-index values for the nomogram were significantly improved (training cohort: vs. MELD-AFP-TBS, 0.148 [0.091-0.204]; vs. CUPI, 0.184 [0.134-0.234]; validation cohort: vs. MELD-AFP-TBS, 0.146 [0.054-0.238]; vs. CUPI, 0.140 [0.050-0.230]; all P < 0.05). Based on the nomogram, an online calculator was developed for individualized assessment of risk level and survival outcomes.
[CONCLUSION] Based on multi-center data, an accessible online calculator was developed to individually forecast the survival prognosis of patients with BCLC stage 0/A HCC and CSPH undergoing Hx.