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Palmitoylated STX11 suppresses AMPK to drive lipogenesis and colorectal cancer.

Biochimica et biophysica acta. Molecular and cell biology of lipids 2026 Vol.1871(3) p. 159730

Li B, Yan Z, Dang W, Han J, Xue H, Wang F, Lili Wang, Yang X, Yang X

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Syntaxin 11(STX11), a SNARE family protein, regulates vesicular trafficking and cytokinesis, yet its functional role in colorectal cancer (CRC) pathogenesis remains poorly understood.

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BibTeX ↓ RIS ↓
APA Li B, Yan Z, et al. (2026). Palmitoylated STX11 suppresses AMPK to drive lipogenesis and colorectal cancer.. Biochimica et biophysica acta. Molecular and cell biology of lipids, 1871(3), 159730. https://doi.org/10.1016/j.bbalip.2026.159730
MLA Li B, et al.. "Palmitoylated STX11 suppresses AMPK to drive lipogenesis and colorectal cancer.." Biochimica et biophysica acta. Molecular and cell biology of lipids, vol. 1871, no. 3, 2026, pp. 159730.
PMID 41621610
DOI 10.1016/j.bbalip.2026.159730

Abstract

Syntaxin 11(STX11), a SNARE family protein, regulates vesicular trafficking and cytokinesis, yet its functional role in colorectal cancer (CRC) pathogenesis remains poorly understood. Here, we identify STX11 as a critical regulator that potentiates CRC progression in vivo and in vitro. Mechanistically, STX11 modulates the AMPK signaling pathway in a palmitoylation-dependent manner, attenuating ACC phosphorylation to enhance its enzymatic activity and stimulate de novo lipogenesis. Genetic ablation of STX11 significantly impedes tumorigenesis in an AOM/DSS-induced CRC mouse model. Our findings establish STX11 as a critical regulator of lipid metabolism in CRC progression and nominate it as a promising therapeutic target.

MeSH Terms

Colorectal Neoplasms; Animals; Lipogenesis; Mice; Humans; AMP-Activated Protein Kinases; Lipoylation; Qa-SNARE Proteins; Cell Line, Tumor; Signal Transduction; Mice, Inbred C57BL; Phosphorylation

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